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Choice B is wrong because probenecid does not affect the absorption or bioavailability of penicillin.
These factors depend on the route of administration and the formulation of the drug.

Choice C is wrong because probenecid does not enhance the bactericidal activity of penicillin.
Penicillin kills bacteria by interfering with their cell wall synthesis, which is independent of probenecid.

Choice D is wrong because probenecid does not reduce the risk of allergic reaction to penicillin. In fact, probenecid may increase the risk of hypersensitivity reactions by prolonging the exposure to penicillin.

Choice B is wrong because the combination of trimethoprim and sulfamethoxazole does not have an additive effect that reduces the dosage and frequency of administration of each drug.
The dosage and frequency of administration are determined by the severity of the infection, the renal function of the client, and the susceptibility of the bacteria.

Choice C is wrong because the combination of trimethoprim and sulfamethoxazole does not have an antagonistic effect that prevents the development of resistance to either drug.
Antagonistic effect means that one drug reduces or cancels out the effect of another drug.
The combination of trimethoprim and sulfamethoxazole may still cause resistance in some bacteria.

Choice D is wrong because the combination of trimethoprim and sulfamethoxazole does not have a selective effect that targets only the bacteria causing the UTI and spares the normal flora.
Selective effect means that a drug affects only certain types of cells or organisms.
The combination of trimethoprim and sulfamethoxazole is a broad-spectrum antibiotic that can affect both gram-positive and gram-negative bacteria, including some normal flora.

Choice A is wrong because taking calcium supplements with food does not prevent the interaction with tetracycline.

Choice B is wrong because avoiding calcium supplements altogether is not necessary and may deprive the client of an important nutrient.

Choice C is wrong because drinking plenty of water does not prevent the interaction with tetracycline either.

Choice B is wrong because it is not enough to instruct the client to monitor for signs of bleeding, such as bruising, hematuria, or melena.
The nurse should also inform the prescriber and check the client’s INR regularly.

Choice C is wrong because it is not advisable to advise the client to increase the intake of vitamin K-rich foods, such as green leafy vegetables, while taking azithromycin.
Vitamin K can reduce the effectiveness of warfarin and increase the risk of clotting. The client should maintain a consistent level of vitamin K intake throughout the treatment with warfarin.

Choice D is wrong because it is not relevant to the question.
Azithromycin does not affect hormonal contraception, such as pills, patches, or rings. The client does not need to use an alternative form of contraception, such as condoms, while taking azithromycin.