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Principles of Medication Administration and Medication Safety
Study Questions
Practice Exercise 1
Which of the following professionals is primarily responsible for administering medications and evaluating therapeutic responses?
Explanation
In the healthcare team, the nurse plays a primary role in administering medications and evaluating therapeutic responses. While providers such as physicians, nurse practitioners, and physician assistants prescribe medications, it is the nurse who is responsible for safely preparing, administering, and monitoring the effects of medications on the patient.
Rationale for correct answer:
3. Nurse: Nurses are responsible for administering medications, monitoring for therapeutic and adverse effects, and reporting outcomes to the healthcare team. They serve as the final safety checkpoint before a medication reaches the patient.
Rationale for incorrect answer:
1. Physician: Physicians are responsible for diagnosing conditions, prescribing medications, and determining treatment plans, but they do not directly administer medications or assess immediate patient responses after administration.
2. Advanced Practice Registered Nurse (APRN): APRNs have prescriptive authority and provide advanced care, but in most settings, they do not carry out routine medication administration or perform frequent post-administration evaluations.
4. Pharmacist: Pharmacists dispense medications and provide education on drug use and interactions. They do not administer medications or assess the patient's response after administration.
Take-home points:
- Nurses are primarily responsible for administering medications and evaluating patient responses.
- Physicians and APRNs prescribe medications but typically do not administer them.
- Pharmacists dispense and educate but do not assess medication effects on patients.
What is the generic name of a medication?
Explanation
The generic name of a medication is the official, universally recognized name assigned by the United States Adopted Names Council (USAN). Unlike the trade (brand) name, which may vary by manufacturer or country, the generic name remains consistent worldwide. Nurses must prioritize the generic name when verifying, administering, and documenting medications to ensure accuracy and prevent medication errors.
Rationale for correct answer:
3. The generic name is the official, universally recognized name assigned by the United States Adopted Names Council. It is used consistently across healthcare settings to promote safety and clarity.
Rationale for incorrect answer:
1. The brand name given by the manufacturer refers to the trade or proprietary name, which is selected for marketing purposes and can vary between companies and countries.
2. The molecular structure of the drug refers to the chemical name, which describes the drug’s exact chemical composition and structure, not the generic name.
4. The trade name used in marketing is the brand name given by the pharmaceutical company to promote the drug commercially, distinct from its generic designation.
Take-home points:
- The generic name is the official drug name assigned by the United States Adopted Names Council.
- Generic names are consistent worldwide, unlike trade names which may vary.
- Nurses should verify and document medications using the generic name to prevent errors.
Which example describes a medication’s mechanism of action?
Explanation
Glipizide is an oral antidiabetic medication classified as a sulfonylurea, commonly used to manage type 2 diabetes mellitus. Its mechanism of action involves stimulating the pancreatic islet cells (beta cells) to release insulin, thereby lowering blood glucose levels. Nurses must understand this pharmacological action to monitor for hypoglycemia, educate patients on timing of doses with meals, and assess blood glucose levels regularly.
Rationale for correct answer:
2. Glipizide stimulates pancreatic islet cells, specifically beta cells, to release insulin, which lowers blood glucose levels. This describes its pharmacological action and explains how it achieves its therapeutic effect in managing type 2 diabetes.
Rationale for incorrect answer:
1. Morphine sulfate causes constipation because it slows gastrointestinal motility by acting on opioid receptors in the gut. This is a common side effect rather than an explanation of the drug’s therapeutic action.
3. Tetracycline stains developing teeth in children because it binds to calcium in developing bones and teeth, leading to discoloration. This is an adverse effect rather than how the drug works against bacteria.
4. Digoxin toxicity increases with hypokalemia because low potassium levels enhance digoxin’s binding to cardiac tissue, increasing its effects and the risk of dysrhythmias. This reflects a condition that worsens toxicity rather than explaining how the drug works.
Take-home points:
- A medication’s mechanism of action explains how it produces its intended therapeutic effect.
- Glipizide lowers blood glucose by stimulating insulin release from pancreatic beta cells.
- Side effects and toxicity risks are different from the drug’s mechanism of action.
Which of the following orders requires immediate administration?
Explanation
A stat order refers to a medication prescription that must be administered immediately to address a critical or life-threatening condition. This type of order takes highest priority over other prescriptions, requiring the nurse to act without delay to promote patient safety and stabilize the patient’s condition. Understanding stat orders is essential for nurses to deliver prompt, effective emergency care in acute clinical situations.
Rationale for correct answer:
3. Stat order indicates that the medication must be administered immediately because it is critical for addressing an acute or life-threatening situation. Prompt administration minimizes complications and improves patient outcomes.
Rationale for incorrect answer:
1. Routine order refers to medications given on a scheduled, ongoing basis such as daily or twice daily. These do not require immediate action and are administered at predetermined times as part of the client’s regular care.
2. Standing order outlines treatments to be carried out under specific conditions (e.g., chest pain or fever), but the medication is only given if the specified situation arises, not automatically or immediately.
4. PRN order authorizes the medication to be administered as needed based on the patient’s condition, but it does not indicate that the medication should be given immediately unless symptoms are present.
Take-home points:
- A stat order requires immediate medication administration to address urgent or life-threatening conditions.
- Routine and PRN orders follow scheduled or as-needed timing, not emergency response.
- Understanding order types helps prioritize timely and appropriate nursing interventions.
Which action demonstrates compliance with the “Right Patient” principle?
Explanation
The Right Patient principle is a fundamental part of safe medication administration. It requires nurses to confirm two patient identifiers, such as the patient’s full name and date of birth, before giving any medication. This practice prevents medication errors caused by misidentification and ensures that the intended patient receives the correct medication, safeguarding patient safety and care quality.
Rationale for correct answer:
2. Confirming two patient identifiers, such as the patient's full name and date of birth, is the essential action for ensuring the medication is given to the correct person, in compliance with the Right Patient principle.
Rationale for incorrect answer:
1. Verifying the patient’s diagnosis helps ensure the medication is appropriate, but it does not directly confirm the patient's identity before administering the drug.
3. Calculating the correct dosage range ensures the Right Dose is administered but does not address confirming the patient’s identity, which is the focus of the Right Patient principle.
4. Administering medications on time fulfills the Right Time requirement but does not verify the patient’s identity, which is critical before any administration.
Take-home points:
- The Right Patient principle requires confirming two identifiers, such as name and date of birth.
- Verifying patient identity prevents medication errors caused by misidentification.
- Other rights like Right Dose or Right Time are important but do not replace identity verification.
Practice Exercise 2
A nurse double-checks the dose and avoids distractions during medication preparation. Which phase of the nursing process does this action reflect?
Explanation
The Implementation phase of the nursing process involves putting the care plan into action, including medication administration. When a nurse double-checks the medication dose and avoids distractions during preparation, these actions reflect safe implementation practices. This phase emphasizes accuracy, focus, and adherence to safety protocols to minimize the risk of medication errors and promote positive patient outcomes.
Rationale for correct answer:
3.Implementation is the phase where the nurse puts the plan into action. Double-checking doses and minimizing distractions during medication preparation are safety-focused actions performed during this phase.
Rationale for incorrect answer:
1. Assessment involves gathering data about the patient’s condition, allergies, and medication history before administration, not the actual preparation or administration of medications.
2. Planning focuses on setting priorities and identifying desired outcomes, such as ensuring medications are prepared and given safely, but it does not involve physically preparing the medications.
4. Evaluation occurs after medication administration, where the nurse observes and determines the effectiveness of the medication and monitors for adverse effects, not during preparation.
Take-home points:
- Implementation is the active phase where safety measures like double-checking doses are executed.
- Avoiding distractions during medication preparation helps prevent administration errors.
- Assessment and planning occur before, and evaluation follows after, the implementation phase.
Which of the following is considered a high-alert medication?
Explanation
High-alert medications, such as insulin, carry an increased risk of causing significant patient harm if used improperly. Nurses must apply strict safety measures, including independent double-checks, accurate dosing, and careful monitoring of blood glucose levels. Understanding the high-risk nature of insulin helps prevent hypoglycemia or hyperglycemia, enhancing patient safety during medication administration.
Rationale for correct answer:
3. Insulin is a high-alert medication because incorrect dosing can lead to severe hypoglycemia or hyperglycemia, both of which can be life-threatening. It requires independent double-checks and precise dosing.
Rationale for incorrect answer:
1. Amoxicillin is a commonly prescribed antibiotic with a relatively low risk of causing severe harm when administered incorrectly. It does not require the same heightened safety precautions as high-alert medications.
2. Ibuprofen is a widely used nonsteroidal anti-inflammatory drug (NSAID). While it has potential adverse effects like gastrointestinal irritation, it is not classified as a high-alert medication.
4. Loratadine is an over-the-counter antihistamine for allergies and is not categorized as high-alert due to its low risk of serious harm with improper use.
Take-home points:
- Insulin is a high-alert medication due to the risk of life-threatening hypoglycemia with incorrect dosing.
- High-alert medications require extra safety measures like double-checks and precise monitoring.
- Drugs like amoxicillin, ibuprofen, and loratadine are not classified as high-alert medications.
What is the recommended strategy to reduce errors with look-alike/sound-alike medications?
Explanation
Tall man lettering is a safety strategy used to distinguish look-alike/sound-alike drug names by capitalizing specific letters within the name. For example, “predniSONE” vs. “prednisoLONE.” This technique helps healthcare providers quickly identify medications correctly, reducing the risk of medication errors and improving safe drug administration practices.
Rationale for correct answer:
2. "Tall man" lettering highlights differences in drug names by capitalizing distinct portions (e.g., predniSONE vs. prednisoLONE). This visual distinction helps prevent selection errors during prescribing, dispensing, and administration.
Rationale for incorrect answer:
1. Using generic names on labels promotes consistency but does not specifically address confusion caused by look-alike or sound-alike drug names, which can still appear similar in their generic forms.
3. Storing different medication types separately improves organization but does not specifically reduce confusion between medications with similar names; errors could still occur if names are misread.
4. Unit-dose packaging minimizes contamination and dosage errors but does not address the visual similarity of drug names, which is the primary concern with look-alike/sound-alike medications.
Take-home points:
- "Tall man" lettering helps differentiate look-alike/sound-alike drug names to prevent errors
- Visual cues like capitalized letters reduce the risk of misreading similar medication names.
- This strategy enhances medication safety during prescribing, dispensing, and administration.
Which FDA pregnancy category indicates proven risk of fetal harm and contraindicates use during pregnancy?
Explanation
Category X medications, as classified by the former FDA pregnancy risk categories, have proven risks of fetal harm based on human and animal studies. These drugs are strictly contraindicated during pregnancy, as the risks far outweigh any potential benefits. Nurses must recognize Category X medications and ensure they are avoided in pregnant clients to protect fetal health.
Rationale for correct answer:
4. Category X drugs are strictly contraindicated during pregnancy because controlled studies in animals or humans have shown clear fetal abnormalities or risks. The risks far outweigh any potential benefits, and these medications should not be used in women who are or may become pregnant.
Rationale for incorrect answer:
1. Category B drugs are considered relatively safe during pregnancy because animal studies have shown no risk to the fetus, though adequate human studies are lacking. These drugs may be prescribed if the healthcare provider deems the potential benefit greater than the unknown risk.
2. Category C drugs have demonstrated adverse fetal effects in animal studies, and no adequate human studies exist. These drugs may still be prescribed if the potential benefit to the mother justifies the potential fetal risk, but they are used cautiously.
3. Category D drugs have confirmed human fetal risk, but they may be necessary in serious or life-threatening conditions where safer alternatives are not available. Use is carefully considered and monitored by the healthcare provider.
Take-home points:
- Category X drugs are contraindicated in pregnancy due to proven fetal harm.
- These medications should never be used in women who are or may become pregnant.
- Nurses must verify pregnancy status before administering Category X medications.
When is medication reconciliation required?
Explanation
Medication reconciliation is a critical safety process that involves comparing a patient’s current medications with newly prescribed drugs during transitions in care, such as admission, transfer, and discharge. This process helps identify discrepancies, prevent omissions or duplications, and ensure continuity of care. Performing medication reconciliation accurately reduces medication errors and promotes patient safety.
Rationale for correct answer:
2. Medication reconciliation is a critical safety process conducted at admission, during internal transfers, and at discharge to ensure medication accuracy across transitions of care. This prevents omissions, duplications, and harmful interactions.
Rationale for incorrect answer:
1. Medication reconciliation is essential at hospital admission, but limiting it to this point neglects the possibility of medication changes during other care transitions, increasing the risk of discrepancies.
3. Although important when new medications are prescribed, reconciliation involves a broader process that verifies the entire medication list during transitions, not just during prescription changes.
4. Annual physical exams focus on preventative care and health maintenance, but medication reconciliation is prioritized during care transitions, where the risk of medication discrepancies is highest.
Take-home points:
- Medication reconciliation is required at admission, transfer, and discharge.
- It ensures continuity and safety by identifying discrepancies in medication lists.
- Accurate reconciliation helps prevent omissions, duplications, and drug interactions.
Practice Exercise 3
Which schedule of controlled substances has no accepted medical use in the U.S. and carries the highest potential for abuse?
Explanation
Schedule I substances are classified as controlled drugs with no accepted medical use in the United States and carry the highest potential for abuse and dependence. Examples include heroin, LSD, and ecstasy, which are illegal for medical treatment. Understanding the controlled substance schedules ensures safe handling and compliance with federal regulations.
Rationale for correct answer:
3. Schedule I substances, such as heroin and LSD, have no accepted medical use in the United States and possess the highest potential for abuse, which is why they are strictly prohibited for medical practice.
Rationale for incorrect answer:
1. Schedule II drugs, such as morphine and oxycodone, have a high potential for abuse and dependence but are recognized for their accepted medical uses under strict prescribing guidelines.
2. Schedule III substances, like ketamine, have a moderate to low potential for physical and psychological dependence and accepted medical uses in the U.S., making them less restricted than Schedules I and II.
4. Schedule V drugs, such as cough preparations containing less than 200 mg of codeine, have the lowest potential for abuse and accepted therapeutic uses, making them the least regulated controlled substances.
Take-home points:
- Schedule I substances have no accepted medical use and the highest abuse potential.
- Examples include heroin, LSD, and ecstasy—prohibited in all medical settings.
- Understanding drug schedules supports safe handling and legal compliance in nursing practice.
Which of the following medications is considered a high-alert medication?
Explanation
Warfarin is classified as a high-alert medication due to its narrow therapeutic range and significant risk of bleeding complications if administered incorrectly. Nurses must perform careful dose verification, monitor INR levels regularly, and educate patients on dietary interactions and signs of bleeding. Extra caution is required during administration, patient education, and monitoring to prevent serious adverse outcomes.
Rationale for correct answer:
2. Warfarin is classified as a high-alert medication because of its potent anticoagulant properties and its narrow therapeutic index. Even small deviations from the prescribed dose can lead to serious adverse outcomes, including life-threatening bleeding or thromboembolic events if the dose is too low.
Rationale for incorrect answer:
1. Acetaminophen is widely used for pain and fever management and is not categorized as a high-alert medication; while overdose can cause hepatotoxicity, it is not typically associated with immediate life-threatening administration errors.
3. Loratadine is an over-the-counter antihistamine used for allergy relief and does not carry the same level of risk if mis-administered, so it is not listed as a high-alert drug.
4. Omeprazole is a proton pump inhibitor used for acid reflux and ulcers. Although improper use can lead to side effects, it does not pose an immediate, life-threatening risk, unlike high-alert medications.
Take-home points:
- Warfarin is a high-alert anticoagulant requiring precise dosing and INR monitoring.
- Small dosing errors with warfarin can cause serious bleeding or clotting complications.
- Nurses must educate patients on diet, signs of bleeding, and drug interactions with warfarin.
What is the first step a nurse should take after a medication error occurs?
Explanation
When a medication error occurs, the nurse's first priority is patient safety. The nurse must immediately assess the patient for adverse effects and notify the healthcare provider (prescriber) to initiate any necessary interventions. Prompt action helps minimize potential harm, ensures timely treatment, and supports the process of error reporting and quality improvement in medication safety.
Rationale for correct answer:
2. The first action is to assess the patient for adverse effects and notify the prescriber promptly so that timely interventions, such as administering an antidote or adjusting therapy, can prevent or reduce harm. Patient assessment ensures that any immediate risks are addressed.
Rationale for incorrect answer:
1. Completing an incident report is an important part of the medication error process but is not the first priority. Immediate patient safety takes precedence over documentation, which is completed later.
3. Documentation of the error in the patient’s chart is required for transparency and continuity of care but should occur after the nurse ensures the patient’s safety and informs the healthcare provider.
4. Informing the nursing supervisor is part of the reporting process but does not address the urgent need to evaluate and manage the patient’s condition immediately following the error.
Take-home points:
- The nurse’s first priority after a medication error is to assess the patient and notify the prescriber.
- Immediate action can reduce harm and guide timely interventions.
- Reporting and documentation follow after patient safety is addressed.
A client taking gentamicin should be monitored for which potential adverse effect?
Explanation
Gentamicin is an aminoglycoside antibiotic used to treat serious infections, but it carries a risk of ototoxicity, especially with prolonged use or high serum levels. Hearing loss, tinnitus, or balance disturbances, are early signs of toxicity. Early detection and reporting of auditory changes are essential to prevent permanent damage and adjust therapy as needed.
Rationale for correct answer:
2. Gentamicin carries a well-known risk of ototoxicity, which can result in hearing loss, tinnitus, or balance disturbances. Nurses should monitor hearing and report any auditory changes to prevent permanent damage.
Rationale for incorrect answer:
1. Hypertension is not a common adverse effect of gentamicin. This antibiotic is more likely to affect the kidneys and the auditory system rather than blood pressure regulation.
3. Hyperglycemia is unrelated to gentamicin use. Blood sugar disturbances are not typically associated with aminoglycoside antibiotics like gentamicin.
4. Constipation is not a common side effect of gentamicin therapy. Gastrointestinal effects are possible but ototoxicity and nephrotoxicity are the most significant concerns.
Take-home points:
- Gentamicin can cause ototoxicity, so clients must be monitored for hearing loss or tinnitus.
- Early detection of auditory changes helps prevent permanent hearing damage.
- Hearing and renal function are the primary concerns with gentamicin, not blood pressure or glucose.
A nurse is reviewing a medication order for a pregnant client. The medication is classified as Pregnancy Category D. The nurse understands that this category indicates:
Explanation
Pregnancy Category D medications are drugs that have shown positive evidence of human fetal risk, but the potential benefits may outweigh the risks in certain clinical situations. Nurses must carefully assess the client’s condition and collaborate with the healthcare provider to determine if the medication is essential for the mother’s health. Safe medication practices include providing patient education on the risks and close monitoring during therapy.
Rationale for correct answer:
3. Pregnancy Category D medications have demonstrated fetal risk based on human studies, but in certain serious or life-threatening conditions, the potential benefit to the mother may justify their use despite these risks.
Rationale for incorrect answer:
1. Animal studies showing no risk but lacking human studies describe Pregnancy Category B, not Category D. Category D reflects known evidence of human fetal risk, not absence of risk in animals.
2. Risk in animals with no adequate human studies describes Pregnancy Category C. Category D is based on human data showing potential harm, making it more severe than Category C.
4. Proven fetal risk with strong contraindication for use in pregnancy describes Pregnancy Category X, not Category D. Category X medications should never be used in pregnancy due to clear evidence of fetal harm.
Take-home points:
- Category D medications pose known fetal risk but may be used if benefits outweigh the risks.
- These drugs require close provider judgment and informed patient consent.
- Nurses must monitor for adverse effects and educate pregnant clients on potential risks.
Comprehensive Questions
A nurse is preparing a client’s medications. Which of the following are legal responsibilities of the nurse? Select all that apply.
Explanation
When preparing and administering medications, nurses have specific legal responsibilities to protect client safety and uphold professional standards. These include maintaining skill competency through continuing education and practice, monitoring for adverse effects during and after medication administration, and safeguarding medications to prevent misuse or diversion. Understanding these responsibilities is essential for maintaining professional accountability and protecting client well-being.
Rationale for correct answers:
1. Maintaining skill competency: Nurses are legally obligated to maintain their clinical competency through continuing education and practice. This ensures they administer medications safely and follow current standards of care.
3. Monitoring for adverse effects: The nurse is legally responsible for monitoring clients for potential adverse reactions. Early detection and intervention prevent harm and fulfill the nurse’s duty to promote patient safety.
4. Safeguarding medications: Nurses are accountable for the security of medications in their care. They must ensure proper storage, prevent unauthorized access, and handle controlled substances according to legal requirements.
Rationale for incorrect answers:
2. Determining the dosage: Determining the dosage is the responsibility of the prescribing healthcare provider. The nurse verifies the ordered dose for safety but does not independently select or calculate the prescribed dose.
5. Identifying the client’s diagnosis: Establishing a medical diagnosis is outside the nurse’s legal scope of practice. Nurses contribute to care planning and recognize clinical signs but do not diagnose illnesses.
Take-home points:
- Nurses must maintain skill competency and practice safe medication administration according to legal standards.
- Nurses are responsible for monitoring for adverse effects to ensure prompt recognition of complications.
- Nurses must safeguard medications by securing storage and preventing unauthorized access.
A nurse is reviewing a client’s health record and notes a new prescription by the provider for lisinopril (Zestril) 10 mg PO every day. The nurse should recognize this as which of the following types of prescription?
Explanation
A routine prescription is a medication order intended for regular, ongoing administration until the provider discontinues it or a specified number of doses have been given. This type of prescription is used for chronic conditions or maintenance therapy, such as antihypertensives or antidiabetic medications. Nurses must understand that routine prescriptions are scheduled medications, requiring timely administration and documentation to ensure consistent therapeutic effects and patient safety.
Rationale for correct answer:
3. Routine prescription: A routine prescription involves administering a medication on a regular schedule until the healthcare provider discontinues or modifies the order. Lisinopril 10 mg daily is a common routine prescription used for managing hypertension or heart failure over the long term.
Rationale for incorrect answers:
1. Single prescription: A single prescription is intended for one-time administration of a medication, usually given at a specific time for a particular purpose, such as a preoperative sedative. Lisinopril prescribed for daily use does not fit this definition, as it is meant for ongoing treatment.
2. Stat prescription: A stat prescription is for immediate administration, typically in emergencies requiring urgent intervention. Since lisinopril is prescribed for daily use, it is not considered a stat order.
4. Standing prescription: A standing prescription refers to pre-established protocols or orders allowing nurses to administer medications in certain situations without a new direct order. Lisinopril generally requires a daily order and is not administered under standing protocols.
Take-home points:
- Routine prescriptions are scheduled for regular, ongoing use and require timely administration and documentation.
- Single and stat prescriptions are for one-time or emergency use and do not apply to chronic medications like lisinopril.
- Standing prescriptions apply to pre-approved protocols, while lisinopril is given as a daily provider-ordered routine medication.
A nurse is reviewing a new prescription for ondansetron (Zofran) 4 mg PO PRN for nausea and vomiting to a client who has hyperemesis gravidarum. The nurse should clarify which of the following parts of the prescription with the provider?
Explanation
Every prescription includes essential components: the client’s full name, date and time of the order, medication name, dosage, route of administration, frequency or timing, and the provider’s signature. Nurses must accurately interpret each part to ensure safe medication administration, prevent errors, and comply with legal and professional standards of care.
Rationale for correct answer:
4. Time: The prescription lacks specific timing or frequency for administration. The term "PRN" indicates it is given as needed, but the provider should clarify the maximum frequency or interval between doses to ensure safe and effective use, especially in pregnancy.
Rationale for incorrect answers:
1. Name: The medication name, ondansetron, is clearly stated and appropriate for treating nausea and vomiting, especially in cases like hyperemesis gravidarum. There is no need to clarify this part of the prescription.
2. Dosage: The dosage of 4 mg is within the recommended range for ondansetron when used for nausea and vomiting. This dosage is considered safe and effective, so no clarification is needed.
3. Route: The route of administration, PO (by mouth), is appropriate for ondansetron and convenient for the client. This is a standard and acceptable route for this medication.
Take-home points:
- A complete prescription must include clear timing or frequency instructions, especially when using PRN medications.
- PRN orders require clarification of maximum dose limits and administration intervals to ensure client safety.
- Nurses must verify all essential parts of a prescription—name, dosage, route, and timing—before administering any medication.
A nurse is orienting a newly hired nurse and discussing how to take a telephone prescription. Which of the following statements by the newly hired nurse indicates understanding of the discussion?
Explanation
A telephone prescription is a verbal medication order communicated by a healthcare provider to a nurse over the phone when the provider is not physically present. To ensure safety and accuracy, another nurse should listen to the phone call as a witness. The nurse receiving the order must write it down immediately and read back the prescription verbatim to confirm all details, including drug name, dosage, route, and frequency. The provider is legally required to sign the telephone order within a specified timeframe.
Rationale for correct answer:
2. “Another nurse should listen to the phone call.” Having a second nurse listen to the telephone prescription ensures that the order is heard correctly and reduces the risk of errors. This collaborative verification is a key safety measure during telephone or verbal orders.
Rationale for incorrect answers:
1. “A second nurse enters the prescription into the client’s health record.” Entering the prescription is the responsibility of the nurse who received the order, but having a second nurse listen to the call is essential to verify accuracy during the telephone prescription process, not just for documentation.
3. “The provider can clarify the prescription when he signs the health record.” The provider must clarify and confirm the prescription at the time of the telephone order, not later during signature. Delaying clarification can lead to medication errors and compromise patient safety.
4. “The ‘read back’ is omitted if this is a one-time prescription.” The ‘read back’ process, where the nurse repeats the order to confirm accuracy, should never be omitted, regardless of whether the prescription is one-time or ongoing. It is a critical step to ensure patient safety.
Take-home points:
- Always have another nurse listen during a telephone prescription to enhance accuracy and safety.
- The nurse receiving the telephone order must document and perform a complete read-back of the prescription.
- The provider must clarify the prescription during the call, not when signing the record later.
A nurse on a medical unit is admitting a client and completing a preassessment before administration of medications. Which of the following data should the nurse include in the preassessment? Select all that apply.
Explanation
When admitting a client to a medical unit, a nurse performs a thorough preassessment before medication administration to ensure safe and effective care. This assessment includes gathering information about the client’s current health status, medication history, allergies, and use of herbal supplements or alternative therapies. It also involves evaluating vital signs and any conditions that might affect medication absorption or action
Rationale for correct answers:
1. Use of herbal teas: Herbal teas can contain active compounds that interact with medications, potentially causing adverse effects or altering drug efficacy. It is important to assess for herbal and supplement use to ensure safe medication administration.
3. Current health status: Understanding the client’s current health status helps the nurse identify any acute conditions or symptoms that may influence medication selection, dosing, or the client’s response to the medication.
5. Food allergies: Food allergies are crucial to assess because some medications contain components derived from food products or may trigger allergic reactions. This information helps prevent potentially life-threatening allergic responses.
Rationale for incorrect answers:
2. Daily fluid intake: While hydration status is important for overall health, daily fluid intake is not typically a critical component of the preassessment specifically for medication administration, unless it directly impacts the medication’s effectiveness or client’s condition.
4. Previous surgical history: Although surgical history is relevant to overall care, it is generally less critical in a medication preassessment unless it directly affects the client’s current condition or medication metabolism.
Take-home points:
- Assess for herbal product use because they may interact with prescribed medications.
- Evaluate the client’s current health status to guide safe medication selection and dosing.
- Identify food allergies to prevent adverse reactions from medication ingredients.
What are the legal responsibilities of the nurse for correctly preparing and administering medications to clients? Select all that apply.
Explanation
Nurses have critical legal responsibilities when preparing and administering medications to ensure client safety and adherence to professional standards. These responsibilities include accurately calculating dosages, verifying medication orders, assessing clients for potential adverse effects, understanding the client’s diagnosis and symptoms correlating to the medication, and maintaining proper documentation.
Rationale for correct answers:
2. The nurse must understand the client’s diagnosis and symptoms correlating to the medication: Nurses are responsible for having sufficient knowledge of the client’s condition and how the prescribed medication relates to it, ensuring safe and appropriate administration and recognizing potential issues.
3. The nurse must assess the client for adverse effects of the medication: Monitoring for adverse reactions and side effects is a key nursing responsibility, enabling early intervention and promoting client safety throughout the medication process.
4. The nurse must be accurate in calculating and preparing medications: Accuracy in medication calculations and preparation is critical to prevent dosing errors, adverse events, and ensure effective therapy, making it a vital legal duty of the nurse.
Rationale for incorrect answers:
1. The nurse must ensure that the client fully understands all the effects of the medication: While educating clients about medications is important, the nurse’s legal responsibility focuses more on providing clear, accurate information rather than ensuring full client understanding, which can vary based on the client’s capacity and consent process.
5. The nurse must administer all medication orders without question: Nurses have a professional and legal obligation to question or clarify any unclear, inappropriate, or potentially harmful medication orders rather than administering them blindly
Take-home points:
- Nurses must understand how the prescribed medication relates to the client’s diagnosis and symptoms.
- Nurses are responsible for assessing the client for potential adverse effects after medication administration.
- Accurate calculation and preparation of medications are essential legal responsibilities to ensure safe dosing.
The nurse preparing the narcotic hydromorphone (Dilaudid) injection needs to get assistance from another licensed healthcare provider when what occurs?
Explanation
When preparing narcotic medications like hydromorphone (Dilaudid), nurses must follow strict safety protocols to prevent errors and diversion. If the ordered dose is smaller than the amount available in a prefilled syringe cartridge, the nurse should seek assistance from another licensed healthcare provider to verify the dose and ensure accurate administration. This double-check process helps maintain patient safety, complies with regulatory requirements.
Rationale for correct answer:
2. The medication is ordered in a dose smaller than what is available in a prefilled syringe cartridge: When the ordered dose is less than the prefilled syringe amount, a second licensed healthcare provider must assist to verify proper partial dosing and ensure accountability, preventing errors and diversion.
Rationale for incorrect answers:
1. The client receives the injected medication and then becomes nauseated and vomits the drug: This is an adverse reaction that requires monitoring and supportive care but does not necessitate assistance with medication preparation.
3. The client states that the drug will not work and refuses to take it: Client refusal is a right that nurses respect; this situation requires patient education and documentation, but not necessarily assistance with medication preparation.
4. The medication ordered is locked in the narcotic drawer: Narcotics are securely stored, but accessing the drawer does not require assistance unless specific protocols demand two-person verification at the time of withdrawal or administration.
Take-home points:
- A second licensed provider must verify when a partial dose of a narcotic from a prefilled syringe is prepared.
- Client refusal of medication requires documentation and patient education, not assistance in medication preparation.
- Managing side effects like nausea after drug administration does not involve another provider during medication preparation.
List in order what steps the nurse takes when preparing and administering a client’s morning medications.
Explanation
2. Check the order to verify the medication is correct.
3. Obtain the medications for administration from the medication room.
5. Triple-check that the correct medication was prepared.
4. Identify the client using two client identifiers before administration.
1. Document the administration of the medications.
Administering medications safely requires the nurse to follow a systematic process to prevent errors and ensure client safety. The nurse begins by checking the medication order, then obtains the medications from the medication room. Before giving the medication, the nurse triple-checks that the correct medication was prepared and identifies the client using two identifiers to confirm the right person receives the medication. Finally, the nurse documents the administration of the medications, completing the process with accurate record-keeping for legal and clinical purposes.
Rationale for correct answer:
2. Check the order to verify the medication is correct: The nurse first reviews the medication order for accuracy, ensuring the correct medication, dose, route, and time are prescribed. This step is essential to prevent medication errors from an incorrect or outdated order.
3. Obtain the medications for administration from the medication room: After confirming the order, the nurse gathers the prescribed medications. This step involves retrieving the correct medication supply from the secure storage area, checking for expiration dates and integrity.
5. Triple-check that the correct medication was prepared: Before administration, the nurse verifies the medication label against the order at three critical points: when selecting the medication, when preparing it, and immediately before administration. This safety check ensures the right drug, dose, and route.
4. Identify the client using two client identifiers before administration: To ensure the medication is given to the correct individual, the nurse confirms the client’s identity using two identifiers, such as name and date of birth, following institutional policies and safety protocols.
1. Document the administration of the medications: After giving the medication, the nurse promptly documents the medication name, dose, route, and time of administration in the medical record. Documentation also includes any observations or client responses as required for continuity of care and legal accountability.
Take-home points:
- Verify the medication order first to confirm correctness before proceeding.
- Triple-check the medication preparation and identify the client with two identifiers before administration.
- Document medication administration immediately after giving the medication to maintain accurate records.
What process is used to eliminate medication errors in the healthcare environment as clients transition from one clinical setting to another?
Explanation
Medication reconciliation is a critical safety process used during transitions of care to ensure accurate and complete medication information is communicated. It involves comparing the client’s current medication orders with the medications they have been taking to identify and resolve discrepancies. This process helps to prevent medication errors, such as omissions, duplications, or dosing mistakes.
Rationale for correct answer:
4. Medication reconciliation: Medication reconciliation is a systematic process that involves comparing a client’s current medication orders to all medications they were previously taking, to avoid errors such as omissions, duplications, or interactions during transitions between healthcare settings. This process significantly reduces medication errors.
Rationale for incorrect answers:
1. Case management: Case management focuses on coordinating patient care and resources, but it is not specifically aimed at eliminating medication errors during transitions of care.
2. Triple checks: Triple checks involve verifying medications three times during preparation and administration, but this process alone does not address errors that can occur during care transitions.
3. Verification: Verification is part of the medication administration process, ensuring the right patient, drug, dose, route, and time, but it does not encompass the comprehensive review needed during setting transitions.
Take-home points:
- Medication reconciliation compares current and previous medications to prevent errors during care transitions.
- This process helps identify and resolve discrepancies like omissions, duplications, or dosing errors.
- Medication reconciliation is essential to maintain continuity and safety when clients move between clinical settings.
The client is taking dutasteride (Avodart). Which client statement indicates the need for more education about the drug?
Explanation
Dutasteride (Avodart) is a medication used to treat benign prostatic hyperplasia by reducing prostate size. Clients should be educated that the capsule must be swallowed whole and not chewed or crushed, as chewing can alter the medication’s absorption and increase the risk of side effects. Understanding proper administration is essential to ensure the medication’s effectiveness and minimize potential harm.
Rationale for correct answer:
4. “I prefer to chew the drug before swallowing it”: Dutasteride capsules should be swallowed whole, not chewed or crushed, because chewing can increase side effects and reduce the medication’s effectiveness. This statement shows a misunderstanding and indicates the need for further education.
Rationale for incorrect answers:
1. “I’m glad I can take the medication with or without food”: Dutasteride can be taken with or without food, so this statement reflects accurate understanding of the drug administration.
2. “It is good that no lab tests and monitoring are required”: Dutasteride generally does not require frequent lab monitoring, making this a correct statement by the client.
3. “This drug is expensive; I’m glad I have prescription coverage”: Dutasteride can be costly, and many clients appreciate insurance coverage, which indicates a realistic understanding of the medication’s financial aspect.
Take-home points:
- Dutasteride capsules must be swallowed whole; chewing or crushing them alters absorption and increases side effects.
- The medication can be taken with or without food without affecting its efficacy.
- Routine lab monitoring is generally not required while taking dutasteride.
The nurse educator on the unit receives a list of high-alert drugs. Which strategy is recommended to decrease the risk of errors with these medications? Select all that apply.
Explanation
A nurse educator plays a vital role in promoting medication safety, especially when managing high-alert drugs—medications that have a higher risk of causing significant harm if used incorrectly. To decrease the risk of errors, recommended strategies include limiting access to these medications, using special labels that clearly identify them as high-alert, providing increased education and information to all staff, and standardizing the ordering and preparation processes to reduce variability and confusion.
Rationale for correct answers:
2. Limit access to these drugs: Restricting access to high-alert medications helps prevent unauthorized use and reduces the risk of medication errors by ensuring only trained personnel handle these drugs.
3. Use special labels for these drugs: Applying distinct labels on high-alert drugs draws attention to their potential risks, increasing awareness and caution among healthcare providers during administration.
4. Provide increased information to staff: Educating staff about the risks and safe handling of high-alert medications enhances their knowledge and vigilance, which decreases the likelihood of errors.
5. Standardize the ordering and preparation of these drugs: Implementing standardized protocols for ordering and preparing high-alert medications minimizes variability, streamlines processes, and reduces the chance of errors.
Rationale for incorrect answer:
1. Store medications alphabetically on their usual shelf: Storing medications alphabetically is not an effective strategy for high-alert drugs because it can increase the risk of selection errors due to similar-sounding or looking drug names. Special storage protocols are recommended instead.
Take-home points:
- Limiting access to high-alert medications reduces the risk of unauthorized use and errors.
- Using special labels and providing staff education raise awareness and promote safe handling of these drugs.
- Standardizing ordering and preparation procedures decreases variability and potential mistakes.
A client refuses to take his prescribed medications. Which is the nurse’s best response to this client?
Explanation
Patient autonomy is a fundamental principle in nursing care. When a client refuses medication, the nurse must respect the client’s rights while ensuring the client is fully informed of the potential consequences. Providing education about the risks of refusal allows the client to make an informed decision and promotes shared responsibility in care.
Rationale for correct answer:
4. Explain the risks of not taking the medication: The nurse supports patient autonomy by clearly explaining what may happen if the medication is not taken. This ensures the patient has a complete understanding of the situation and can make an informed decision based on both the potential benefits of the medication and the risks of refusal.
Rationale for incorrect answers:
1. Explain the benefits and side effects of the drug: Educating about benefits and side effects is important but incomplete. The client also needs to understand the risks of not taking the medication to make an informed refusal.
2. Leave the medication at the client’s bedside to be taken later: Leaving medication unattended violates safe medication practices and could lead to errors, overdose, or ingestion by unauthorized persons.
3. Persuade the client to take the medication: Persuasion may disregard patient autonomy. Instead, the nurse should support informed decision-making rather than coercing the client.
Take-home points:
- Respecting patient autonomy means supporting informed choices, not forcing compliance.
- Nurses must explain the risks when a patient refuses medication.
- Leaving medication unattended is unsafe and violates medication administration policies.
What information is essential for the nurse to know related to right documentation? Select all that apply.
Explanation
Accurate and timely documentation is a critical nursing responsibility that ensures safe and effective medication administration. Essential information includes recording the correct site of injectable medication, the client’s response to evaluate drug effectiveness, and precise details such as drug name, dose, and route. Additionally, documenting the date and time of dose along with the nurse’s initials or signature provides legal accountability and confirms the medication was given as prescribed.
Rationale for correct answers:
2. Correct site of injectable medication: Documenting the exact injection site is crucial for monitoring potential complications such as irritation, infection, or abscess formation and helps ensure proper technique in future administrations.
3. Client response to antiemetic: Recording the client’s response to medication provides important information on the drug’s effectiveness and any adverse effects, guiding ongoing treatment decisions.
4. Drug name, dose, route: Accurate documentation of these details ensures clarity in the medication administration record and helps prevent medication errors.
5. Date and time of dose and necessity for RN initial/signature: Including the date, time, and nurse’s initials or signature is essential for legal accountability, maintaining an accurate timeline, and confirming that the medication was administered by a licensed professional.
6. Necessity to document all medications given at the end of shift: Documentation should occur immediately after administration, not delayed until the end of the shift, to maintain accuracy and prevent omissions.
Rationale for incorrect answer:
1. Necessity to document all medications given at the end of shift: Documenting medications only at the end of the shift can lead to inaccurate or incomplete records. Documentation should be completed immediately after administration to ensure accuracy and patient safety.
Take-home points:
- Document the correct injection site to monitor for complications and ensure proper technique.
- Record the client’s response to medications to evaluate effectiveness and detect adverse effects.
- Include drug name, dose, route, date, time, and nurse’s signature to maintain accurate, legal medication records.
The nurse prepares to administer medications. Which are complete drug orders? Select all that apply.
Explanation
A complete drug order or prescription is essential to ensure safe and accurate medication administration. It must contain the client’s full name, the drug name, the dosage, the route of administration, the frequency or timing of the dose, and the provider’s signature. Including all these elements helps prevent errors, clarifies the healthcare provider’s intent, and ensures that the nurse administers the medication correctly and legally.
Rationale for correct answers:
1. Aspirin 81 mg, PO, daily: This prescription contains all the essential components: the drug name (aspirin), dose (81 mg), route of administration (by mouth), and frequency (daily). These elements provide clear and specific instructions, which are necessary to ensure safe and accurate medication administration.
4. Ciprofloxacin HCl (Cipro) 500 mg PO q 12h × 7d: This order is detailed and complete, containing all necessary information: medication name (with generic and brand names), dose (500 mg), route (oral), frequency (every 12 hours), and duration (7 days). This clarity minimizes the potential for misinterpretation and errors.
5. Promethazine 50 mg IV q3-6h PRN for nausea: This prescription provides comprehensive information, including drug name, dose, route (intravenous), frequency (every 3 to 6 hours as needed), and indication (for nausea). Including the purpose helps guide appropriate administration and evaluation of effectiveness.
Rationale for incorrect answers:
2. Multivitamin 1 daily: Although this order specifies the medication and frequency, it lacks the route of administration. Without the route (e.g., PO, IV), the nurse may be uncertain how to administer the medication, increasing the risk of errors.
3. Vitamin D, 2000 units, PO: This order includes the drug name, dose, and route, but it does not specify how often the medication should be given. Frequency is essential for dosing schedules to maintain therapeutic levels and avoid under- or overdosing.
Take-home points:
- A complete drug order must include drug name, dose, route, frequency, and duration if applicable.
- Missing route or frequency makes a drug order incomplete and unsafe for administration.
- Including the medication indication in PRN orders helps guide appropriate use and monitoring.
The nurse had just finished filling out the form that is used to report a medication error, and was recalling the ways to prevent errors. Match the type of medication error with the action used to prevent it.
Explanation
Medication errors can occur at various points in the medication use process, including prescribing, dispensing, administration, and monitoring. To reduce these errors, nurses must apply specific prevention strategies. Monitoring these errors are reduced by assessing the client thoroughly before and after medication administration to detect adverse effects or therapeutic responses. The following are some of the ways to prevent the errors:
Rationale for correct answers:
Prescribing errors: Taking the time to carefully review drug name and dose helps prevent errors such as selecting the wrong medication due to look-alike or sound-alike drug names. This step ensures that the provider's order is clear and appropriate for the client's condition and therapeutic needs.
Administration errors: Following routine procedures, such as the "rights" of medication administration (right client, drug, dose, route, and time), helps nurses prevent errors during medication delivery. These safety checks ensure that the correct medication reaches the intended client in the correct manner.
Dispensing errors: Being familiar with medications before administration allows nurses and pharmacists to recognize potential discrepancies in drug selection, dosage form, or packaging. This knowledge helps identify if a medication does not match the client’s prescription or clinical condition.
Monitoring errors: Assessing the client before giving medications ensures that the drug is appropriate based on the client’s current health status, allergies, and laboratory results. This step helps detect potential contraindications or the need for dosage adjustments prior to administration.
Take-home points:
- Careful review of drug names and doses prevents prescribing errors caused by look-alike or sound-alike medications.
- Following routine medication administration procedures reduces administration errors and promotes safe practice.
- Assessing the client before giving medications helps prevent monitoring errors by identifying contraindications or risks.
Exams on Principles of Medication Administration and Medication Safety
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Objectives
- Understand safe medication administration, error prevention strategies, and legal responsibilities of nurses.
- Identify and distinguish between chemical, generic, and trade names, and classify drugs as controlled or uncontrolled substances.
- Explain mechanisms of action, therapeutic effects, side effects, adverse effects, interactions, and contraindications of medications.
- Accurately implement the “Five Plus Five” rights to ensure patient safety during medication administration.
- Identify common medication errors, apply the nursing process, and follow safety protocols to prevent harm.
- Implement precautions with high-alert medications and reduce confusion with look-alike/sound-alike drugs.
- Document medication administration correctly and communicate clearly using standardized orders and reconciliation.
- Respect patients’ right to refuse medication and uphold nurses’ rights to safe practice and complete medication information.
Introduction
Medication administration is one of the most critical responsibilities entrusted to nurses in the healthcare system. It involves not only technical skill but also a comprehensive understanding of pharmacology, patient safety, legal standards, and ethical considerations. Nurses must ensure that medications are administered correctly, safely, and in accordance with professional guidelines to promote optimal patient outcomes.

Healthcare providers such as physicians, advanced practice registered nurses (APRNs), dentists, and physician assistants play a pivotal role in diagnosing conditions, prescribing medications, and monitoring therapeutic responses. These professionals are responsible for obtaining detailed medical histories, conducting physical examinations, making clinical diagnoses, and adjusting medication regimens as necessary. However, it is the nurse who carries out the actual administration of these medications and evaluates the patient’s response to therapy.
In addition to administering medications, nurses must be well-versed in the laws and policies governing medication use at the federal, state, and institutional levels. This includes understanding controlled substance regulations, safe storage practices, documentation requirements, and error reporting protocols. Nurses must also maintain up-to-date knowledge about all medications they administer, including their mechanisms of action, therapeutic effects, side effects, contraindications, and potential interactions.
Moreover, nurses must demonstrate competence in medication preparation, calculation, and administration across various routes. They are responsible for verifying the accuracy of medication orders, ensuring proper dosing, identifying patients correctly, and documenting each administration thoroughly. Importantly, nurses must report any medication errors promptly and participate in quality improvement initiatives aimed at preventing future incidents.
Medication Administration
3.1. Medication classification and nomenclature
Understanding medication nomenclature is essential for safe and effective drug administration.
Each medication may have multiple names:
- Chemical Name: Based on the molecular structure of the drug.
- Generic Name: Assigned by the United States Adopted Names Council, this is the official name used universally.
- Trade Name: Also known as the brand or proprietary name, assigned by the pharmaceutical manufacturer and may vary depending on the country or region.

Prescription medications require supervision due to their potential for abuse or serious side effects.
These medications fall into two broad categories:
- Uncontrolled Substances: Require provider oversight but pose no significant risk of abuse or addiction. Examples include antibiotics and antihypertensives.
- Controlled Substances: Classified into five schedules based on their potential for abuse and accepted medical use:
- Schedule I: No accepted medical use in the U.S. (e.g., heroin).
- Schedules II–V: Medical uses exist with decreasing levels of abuse potential. For example, morphine sulfate (Duramorph) is a Schedule II medication that has a greater risk of abuse and dependence than phenobarbital (Luminal), which is a Schedule IV medication.
Before approval, new drugs undergo rigorous testing procedures established by the Food and Drug Administration (FDA) to determine both effectiveness and safety. However, newly released drugs may have previously unreported adverse effects, which, if observed, nurses can report online at www.fda.gov/medwatch.
3.2. Knowledge required prior to medication administration
To safely administer medications, nurses must understand several key aspects of each drug:
Medication Category/Class
Medications may be organized according to pharmacological action, therapeutic use, body system affected, chemical makeup, and safety during pregnancy. For example, lisinopril (Zestril) is classified as an angiotensin-converting enzyme inhibitor (pharmacological action) and an antihypertensive (therapeutic use).
Mechanism of Action
This refers to how the medication produces the desired therapeutic effect. For instance, glipizide (Glucotrol) lowers blood glucose levels primarily by stimulating pancreatic islet cells to release insulin.
Therapeutic Effect
The preferred and expected outcome of the medication. One medication may have more than one therapeutic effect. Acetaminophen (Tylenol), for example, may be used to lower fever or relieve pain depending on the patient's condition.
Side Effects
Usually expected and inevitable when a medication is given at a therapeutic dose. Morphine sulfate often causes constipation, which is a known side effect.
Adverse Effects
Undesired, inadvertent, and unexpected dangerous effects of the medication. Gentamicin, for example, can cause hearing impairment.
Toxic Effects
Specific risks and manifestations of toxicity. A client taking digoxin (Lanoxin) should be monitored closely for dysrhythmias, a sign of cardiotoxicity. Hypokalemia increases the risk of digoxin toxicity.
Medication Interactions
Medications can interact with each other, resulting in either desired or undesired effects. A desired interaction occurs when atenolol (Tenormin) is used with nifedipine (Procardia) to prevent reflex tachycardia. An undesired interaction may occur when omeprazole (Prilosec) is prescribed concurrently with phenytoin (Dilantin), potentially increasing the serum level of the anticonvulsant.
Precautions and Contraindications
Certain medications may be contraindicated for clients with specific diseases or conditions. Tetracycline, for example, can stain developing teeth and should not be administered to children under 8 years of age. Vancomycin (Vancocin) should be used cautiously in clients with renal impairment.
Preparation, Dosage, and Administration
Special considerations may apply to preparation, recommended dosages, and administration methods. Oral doses of morphine are generally higher than parenteral doses due to extensive first-pass metabolism. Clients with chronic severe pain, such as those with cancer, are typically given oral doses of morphine.
Nursing Implications
Nurses must know how to monitor therapeutic effects, prevent and treat adverse effects, provide comfort measures, and instruct clients in the safe use of medications.

3.3. Medication orders and documentation
Facilities have written policies regarding medication prescriptions, including which providers can write, receive, and transcribe them.
Common types of medication orders include:
- Routine Order/Standard Prescription: Administered on a regular schedule and remains in effect until discontinued or the patient is discharged.
- Single/One-Time Prescription: Given once at a specified time.
- Stat Prescription: Given immediately.
- PRN Prescription: Stipulates dosage, frequency, and conditions under which the medication may be given.
- Standing Orders: Written for specific circumstances or units, such as treating a client in cardiac arrest.
Each medication order must contain the following components:
- Patient’s name
- Date and time of prescription
- Drug name (generic preferred)
- Dosage
- Route of administration
- Time and frequency of medication administration
- Provider’s signature
Communication of medication orders involves accurate transcription, verification, and timely documentation.
Verbal or telephone orders must be read back to the prescriber for verification and cosigned within 24 hours.
Electronic health records (EHRs) enhance safety by reducing transcription errors and alerting providers to potential drug interactions.
Medication Reconciliation is a Joint Commission-mandated process that ensures continuity of care by comparing current medications with new prescriptions to resolve discrepancies. It occurs upon admission, transfer, and discharge.
3.4. Six rights of safe medication administration
(Expanded to "Five Plus Five")
The foundation of safe medication administration lies in adhering to the rights:
- Right Patient – Verified using two identifiers such as name and date of birth.
- Right Medication – Confirmed by checking labels three times.
- Right Dose – Calculated accurately and verified against usual ranges.
- Right Route – Matched to formulation and condition.
- Right Time – Administered within ±30 minutes unless otherwise specified.
- Right Documentation – Recorded immediately after administration.
Additional rights include:
- Right Assessment – Checking baseline data before administration (e.g., apical pulse before digoxin).
- Right Education – Providing patients with necessary information about their medications.
- Right Evaluation – Assessing whether the medication achieved the desired effect.
- Right to Refuse – Respecting the patient’s right to decline medication and documenting the refusal.

Medication Safety
Medication error prevention
Common medication errors include:
- Wrong medication or intravenous fluid
- Incorrect dose or infusion rate
- Wrong patient, route, or time
- Administration of known allergenic medication
- Omission or incorrect discontinuation
Use of the nursing process—assessment, planning, implementation, and evaluation—is crucial in preventing errors.
Assessment involves knowing the medication, checking allergies, reviewing pre-administration data, and verifying prescription completeness. Nurses should consult resources like drug references, poison control centers, and professional journals.
Planning focuses on identifying outcomes and setting priorities.
Implementation emphasizes avoiding distractions, double-checking high-alert medications, and following the six rights. Nurses should never administer medications prepared by others and should follow laws regarding controlled substances.
Evaluation includes assessing patient response, recognizing adverse effects, and reporting errors promptly. Incident reports must be completed within 24 hours and include details such as patient ID, medication name, dose, location, event description, actions taken, and signatures.
High-alert medications
High-alert medications carry a higher risk of harm if administered incorrectly. Examples include:
- Insulin
- Anticoagulants
- Narcotics
- Chemotherapy agents
- Sedatives
The Institute for Safe Medication Practices (ISMP) recommends strategies such as standardization, limiting access, using auxiliary labels, and performing independent double-checks.
Look-alike/sound-alike drugs
- Some medications have names that are easily confused. Examples include:
- Amaryl vs. Reminyl
- Avinza vs. Evista
- Humalog Mix vs. Humulin
To reduce confusion, ISMP and The Joint Commission recommend using “tall man” lettering (e.g., risperidone → RISPERidone).

Medication disposal and sharps safety
- Proper disposal of medications includes:
- Mixing with undesirable substances like coffee grounds
- Participating in local take-back programs
- Removing personal information from containers
Sharps safety is governed by OSHA regulations, requiring:
- Use of safety-engineered devices
- Maintaining a sharps injury log
- Training staff on safe practices
Special Considerations, Guidelines And Nursing Insights
Special considerations in medication administration
Pregnancy Categories (FDA)
|
CATEGORY |
DESCRIPTION |
|
B |
Animal studies show no risk; human studies lacking |
|
C |
Risk in animals; no adequate human studies |
|
D |
Known human risk; use only if benefit outweighs risk |
|
X |
Proven risk; avoid during pregnancy |
Note: The FDA is phasing out this classification system in favor of more detailed labeling.

Factors That Modify Drug Response
These include:
- Age, weight, and body composition
- Hepatic and renal function
- Genetic factors (pharmacogenetics)
- Disease states
- Drug interactions
Guidelines for safe medication administration
Preparation
• Wash hands thoroughly
• Check allergy history
• Verify medication order and expiration date
• Recalculate doses when necessary
• Prepare medications in a clean, distraction-free environment
Administration
• Identify the patient correctly
• Stay with the patient until medication is swallowed
• Use correct technique for each route
• Never recap needles
• Store medications securely, especially controlled substances
Documentation
• Record:
• Drug name, dose, route, and time
• Patient response
• Refusals and reasons
• Chart PRN medications after administration
Behaviors to avoid during medication administration
Avoid engaging in the following behaviors:
• Being distracted while preparing medications
• Giving medications prepared by others
• Using unlabeled or expired medications
• Guessing about drugs or dosages
• Leaving medications unattended
• Recap needles
• Mixing medications with large amounts of food or beverages
• Calling a patient by name alone for identification
• Administering medication if the patient reports it looks different
Resources for medication safety
Key resources for preventing medication errors include:
• Institute for Safe Medication Practices (ISMP) – www.ismp.org
• FDA MedWatch – www.fda.gov/medwatch
• The Joint Commission (TJC) – www.jointcommission.org
• Quality and Safety Education for Nurses (QSEN) – www.qsen.org
• Agency for Healthcare Research and Quality (AHQR) Toolkits – www.ahrq.gov
Nurses’ rights when administering medications
In addition to the rights of medication administration, there are six rights for nurses who administer medications. These rights provide an additional layer of safety by ensuring that the nurse has what is needed to provide safe medication administration.
- Right to a complete and clear order
- Right to receive the correct drug, form, and dose
- Right to access accurate medication information
- Right to policies guiding safe practice
- Right to identify and report system problems
- Right to stop, think, and be vigilant when administering medications
Nursing Insights
Follow the “Five Plus Five” Rights
Ensure right patient, drug, dose, route, time, plus assessment, documentation, education, evaluation, and respect for the patient’s right to refuse.
Verify Medication Orders
Confirm completeness, clarity, and accuracy of all medication orders before administration.
Use Technology Wisely
Leverage EHRs, bar coding, and automated dispensing systems to reduce errors—but always use clinical judgment.
Assess Before Administering
Review allergies, lab results, vital signs, and patient condition before giving any medication.
Prevent High-Alert Medication Errors
Use double-checks, standardization, and clear labeling for high-risk drugs like insulin, anticoagulants, and narcotics.
Promote Medication Reconciliation
Compare current and new medication lists at every care transition to avoid omissions, duplications, or interactions.
Educate Patients
Teach patients about their medications, including purpose, side effects, timing, and how to take them safely at home.
Report and Learn from Errors
Immediately report all medication errors and near misses, complete incident reports, and participate in safety improvements.
Summary
Safe medication administration is a core nursing responsibility that demands knowledge of pharmacology, federal and institutional policies, and individual patient factors, along with critical thinking, attention to detail, and strict adherence to established procedures.
Nurses are key advocates for patient safety , actively involved in preventing medication errors through continuous learning, accurate assessment, proper documentation, and clear communication with both patients and healthcare providers.
The "Five Plus Five Rights" framework guides safe medication practices, ensuring the right patient receives the right medication, dose, route, and time, while also emphasizing the importance of assessment, documentation, education, evaluation, and respecting the patient’s right to refuse.
Medication errors can occur at any stage of the process , including prescribing, dispensing, administering, and monitoring. Nurses must use the nursing process, consult reliable resources, follow safety protocols (e.g., bar coding, double-checking high-alert medications), and report errors promptly to mitigate harm.
Creating a culture of safety involves using technology (e.g., EHRs, automated dispensing systems), adhering to standardized practices, promoting medication reconciliation, avoiding distractions during medication preparation, and fostering open communication to support error prevention and quality improvement.
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