Which drug class should not be used when a patient is taking nitrates?

Nitroglycerin transdermal patches are used to prevent episodes of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart).Nitroglycerin is a vasodilator that works by relaxing the blood vessels so that the heart does not need to work as hard and therefore does not need as much oxygen.However, if nitroglycerin is used continuously, the body may develop tolerance to its effects, meaning that it will not work as well to prevent angina attacks.Therefore, it is important to remove the patch at bedtime and apply a new one in the morning, leaving a 10-12 hour nitrate-free interval.This way, the body can restore its sensitivity to nitroglycerin and avoid angina episodes during the day.

Choice A is wrong because allergic response is not a common reason to remove the patch at night.Although some people may experience skin irritation or rash from the patch, this is usually mild and does not require discontinuation of the medication.If the skin reaction is severe or bothersome, the patch can be applied to a different area of the skin or switched to another form of nitroglycerin.

Choice C is wrong because overdose is unlikely to occur from using the patch as prescribed.Nitroglycerin patches come in doses ranging from 0.1 milligrams per hour to 0.8 mg/hr, and should be placed on clean, dry, and hairless skin for 12-14 hours and removed for 10-12 hours.If a patch loosens or falls off, it should be replaced with a fresh one.Overdose symptoms may include severe headache, dizziness, blurred vision, nausea, vomiting, sweating, chest pain, fast or irregular heartbeat, difficulty breathing, fainting, or seizures.If these occur, the patch should be removed immediately and medical attention should be sought.

Choice D is wrong because management of BPH (benign prostatic hyperplasia) is not related to nitroglycerin use.

BPH is a condition

This range of systolic blood pressure is classified as stage 1 hypertension according to the American College of Cardiology and the American Heart Association. Stage 1 hypertension is when blood pressure consistently ranges from 130 to 139 systolic or 80 to 89 mm Hg diastolic.At this stage of high blood pressure, health care professionals are likely to prescribe lifestyle changes and may consider adding blood pressure medication based on your risk of atherosclerotic cardiovascular disease, or ASCVD, such as heart attack or stroke.

Choice A is wrong because 140 to 159 is the range for stage 2 hypertension, which is more severe than stage 1.

Stage 2 hypertension is when blood pressure consistently is 140/90 mm Hg or higher.At this stage of high blood pressure, health care professionals are likely to prescribe a combination of blood pressure medications and lifestyle changes.

Choice C is wrong because 110 to 119 is the range for normal blood pressure.

Normal blood pressure is when systolic blood pressure is less than 120 mm Hg and diastolic blood pressure is less than 80 mm Hg.If your results fall into this category, stick with heart-healthy habits like following a balanced diet and getting regular exercise.

Choice D is wrong because 120 to 139 is not a valid range for systolic blood pressure.

It includes two different categories: elevated and stage 1 hypertension.

Elevated blood pressure is when readings consistently range from 120-129 systolic and less than 80 mm Hg diastolic.People with elevated blood pressure are likely to develop high blood pressure unless steps are taken to control the condition.Stage 1 hypertension, as explained above, is when systolic blood pressure ranges from 130 to 139 or diastolic blood pressure ranges from 80 to 89.

The normal range for systolic blood pressure is less than 120 mm Hg.The normal range for diastolic blood pressure is less than 80 mm Hg.