Which administration strategy can a patient implement to reduce flushing, the most common adverse effect of niacin therapy?
Take before starting daily activities.
Take with a sedative.
Take with grapefruit juice.
Take with an NSAID such as ibuprofen.
The Correct Answer is D
Taking niacin with an NSAID such as ibuprofen can reduce flushing, the most common adverse effect of niacin therapy. Flushing is a side effect of taking large doses of niacin (vitamin B3) supplements. It happens when the niacin causes the small blood vessels in your skin to dilate so more blood can rush through. Flushing can cause skin redness, warmth, itching, tingling, or burning sensations.
Choice A is wrong because taking niacin before starting daily activities can increase the risk of flushing and interfere with your routine. Flushing usually occurs within 15 to 30 minutes of taking niacin and lasts for about an hour.
Choice B is wrong because taking niacin with a sedative can increase the risk of liver damage, especially if the sedative is acetaminophen (Tylenol). Niacin can also cause liver problems at high doses, so combining it with another liver-toxic drug is not advisable.
Choice C is wrong because taking niacin with grapefruit juice can increase the risk of side effects, such as low blood pressure, dizziness, or fainting. Grapefruit juice can interfere with the metabolism of some drugs, including niacin, and make them more potent or toxic.
Normal ranges for niacin intake vary depending on age and gender. The recommended dietary allowance (RDA) for adult males is 16 mg per day and for adult females is 14 mg per day. Higher doses of niacin may be prescribed by a doctor to treat high cholesterol or other conditions, but they should be taken under medical supervision and with caution.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
Diuretics are medicines that help the kidneys get rid of excess water and salt, which can ease the symptoms of heart failure, such as breathlessness and swelling.However, diuretics may have some side effects, such as loss of potassium, which can affect the heart and require regular blood tests and dietary changes.Diuretics can also cause other electrolyte abnormalities, such as hyponatremia, hypomagnesemia, hypocalcemia, and metabolic alkalosis. Electrolyte disturbances can have serious consequences for the heart function and rhythm, as well as other organs.
Choice A is wrong because fluid retention is the opposite of what diuretics do.
Diuretics reduce fluid retention by increasing urine output and decreasing blood volume.
Choice B is wrong because hypotension is not a direct effect of diuretics on the heart, but rather a consequence of reduced blood volume and vasodilation.
Hypotension can occur with diuretic use, especially if the dose is too high or the patient is dehydrated, but it is not a specific condition caused by diuretics.
Choice C is wrong because hyperglycemia is not related to diuretics or heart failure.
Hyperglycemia is a condition of high blood sugar, which can be caused by diabetes or other factors.
Diuretics do not affect blood sugar levels directly, although some diuretics may interact with diabetes medications and affect their efficacy.
Correct Answer is C
Explanation
Phenazopyridine hydrochloride (Pyridium) is a urinary tract analgesic that can relieve the pain, burning, and discomfort caused by infection or irritation of the urinary tract.However, it can also cause some side effects, one of which is changing the color of bodily secretions to reddish orange. This is due to the excretion of the drug in the urine, saliva, sweat, and tears.The color change is harmless and usually disappears when the drug is stopped.
Choice A is wrong because phenazopyridine does not change bodily secretions to alkaline.In fact, it may interfere with the urine test that measures acidity (pH) and glucose.
Choice B is wrong because phenazopyridine does not change bodily secretions to pinkish.However, some other drugs, such as rifampin and doxorubicin, may cause urine to turn red or pink.
Choice D is wrong because phenazopyridine does not change bodily secretions to black.However, some other drugs, such as metronidazole and nitrofurantoin, may cause urine to turn brown or dark yellow.
Some other common side effects of phenazopyridine include headache, dizziness, indigestion, and stomach pain.Some serious side effects include skin itching, interference with the oxygen-carrying capacity of red blood cells, hemolytic anemia, and renal and hepatic toxicity.
These problems are more common in people who have existing kidney problems or take more than recommended.If you experience any of these symptoms, stop taking phenazopyridine hydrochloride and talk to a healthcare provider right away.
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