In which condition is leg pain produced upon increased activity and ischemia to tissues, but then the pain is reduced with rest?

Atorvastatin is a type ofstatin, which are the most potent antilipidemic agents, and have proven to lower the risk of myocardial infarction by reducing the levels of low-density lipoprotein (LDL) cholesterol and triglycerides in the blood.Statins also slightly increase the level of high-density lipoprotein (HDL) cholesterol, which is beneficial for cardiovascular health.

Choice B, niacin, is a type ofnicotinic acid, which can lower LDL cholesterol and triglycerides, and increase HDL cholesterol, but it is less effective than statins and has more side effects, such as flushing, itching, and liver toxicity.

Choice C, gemfibrozil, is a type offibric acid derivative, which can lower triglycerides and increase HDL cholesterol, but have little effect on LDL cholesterol.They are mainly used for patients with high triglyceride levels or low HDL cholesterol levels.

Choice D, amlodipine, is not an antilipidemic agent at all.It is a type ofcalcium channel blocker, which is used to treat hypertension and angina by relaxing the blood vessels and reducing the workload of the heart.

Pentoxifylline is a medication that improves blood flow and oxygen delivery to the tissues in patients with peripheral vascular disease (PVD), a condition that causes narrowing of the arteries in the legs.Pentoxifylline can help reduce the symptoms of intermittent claudication, which is cramping pain in the legs that occurs with walking and improves with rest.

Choice A is correct because smoking is a major risk factor for PVD and quitting smoking can improve blood flow and prevent further damage to the arteries.

Choice B is correct because prolonged sitting or standing can reduce blood flow to the legs and worsen symptoms of PVD.

Patients should avoid crossing their legs, wearing tight clothing, or exposing their legs to cold temperatures.They should also elevate their legs when resting and move them frequently.

Choice C is wrong because pentoxifylline should be taken on an empty stomach, at least one hour before or two hours after meals, to increase its absorption and effectiveness.

Choice D is wrong because physical activity is beneficial for patients with PVD and intermittent claudication.

Exercise can improve blood circulation, increase muscle strength, reduce pain, and lower cardiovascular risk factors.Patients should be encouraged to walk regularly, as tolerated, and follow a supervised exercise program if available.