Which of the following Alpha adrenergic class has a vasodilating effect and can be used for the management of hypertension?

According to the World Health Organization (WHO), noncommunicable diseases (NCDs) are the leading cause of death globally, accounting for 74% of all deaths. NCDs are chronic diseases that are not transmitted from person to person, such as cardiovascular diseases, cancers, chronic respiratory diseases and diabetes.The main risk factors for NCDs are modifiable behaviours, such as tobacco use, physical inactivity, unhealthy diet and the harmful use of alcohol.These behaviours can lead to metabolic risk factors, such as raised blood pressure, increased blood glucose, elevated blood lipids and obesity, which in turn increase the risk of developing NCDs. Therefore, lifestyle changes that reduce these risk factors can prevent or delay many NCDs and improve health outcomes.

Choice A is wrong because trauma is not a major contributing factor to many diseases.Trauma is an injury or damage to living tissue caused by an external force, such as accidents, violence or natural disasters.Trauma can result in acute or chronic conditions, such as infections, fractures, burns, bleeding or organ failure.

However, trauma is not a common cause of NCDs, which are the main burden of disease globally.

Choice C is wrong because congenital factors are not the greatest contributing factor to many diseases.Congenital factors are those that are present at birth, such as genetic disorders, birth defects or inherited diseases.Congenital factors can affect the development and function of various organs and systems in the body, leading to various health problems.

However, congenital factors are not the main cause of NCDs, which are largely influenced by environmental and behavioural factors.

Choice D is wrong because genetics is not the greatest contributing factor to many diseases.

Genetics is the study of how traits are inherited and expressed in living organisms.

Genetics can influence the susceptibility and resistance to various diseases, as well as the response to treatment and prevention strategies.

However, genetics is not the sole determinant of health and disease, as environmental and behavioural factors also play a significant role in modulating gene expression and function.

Exposure to cold temperatures should be avoided by the patient with peripheral vascular disease such as Raynaud’s disease.

This is because cold temperatures can trigger vasospasm, which is a sudden narrowing of the small arteries in the fingers or toes, limiting blood flow and causing pain, numbness and color changes.

Choice A is wrong because wearing warm mitten gloves can help prevent or reduce the severity of Raynaud’s attacks by keeping the hands warm.

Choice B is wrong because wearing socks can also help protect the feet from cold exposure and prevent or reduce Raynaud’s attacks.

Choice D is wrong because engaging in regular exercise can improve blood circulation and reduce the frequency and duration of Raynaud’s attacks.However, exercise should be done with caution and proper clothing to avoid injury or frostbite to the affected areas.

Normal ranges for peripheral vascular disease are not applicable, as it is a condition that affects the blood vessels and not a specific blood test or measurement.

However, some tests that can help diagnose peripheral vascular disease or its underlying causes are blood pressure measurement, ankle-brachial index, Doppler ultrasound, angiography, blood tests for cholesterol, glucose, clotting factors and inflammatory markers.