Which of the following anti-lipidemic drugs are the most potent antilipidemic agents, and have proven to lower the risk of Myocardial Infarction?
Atorvastatin.
Niacin.
Gemfibrozil
Amlodipine.
The Correct Answer is A
Atorvastatin is a type of statin, which are the most potent antilipidemic agents, and have proven to lower the risk of myocardial infarction by reducing the levels of low-density lipoprotein (LDL) cholesterol and triglycerides in the blood. Statins also slightly increase the level of high-density lipoprotein (HDL) cholesterol, which is beneficial for cardiovascular health.
Choice B, niacin, is a type of nicotinic acid, which can lower LDL cholesterol and triglycerides, and increase HDL cholesterol, but it is less effective than statins and has more side effects, such as flushing, itching, and liver toxicity.
Choice C, gemfibrozil, is a type of fibric acid derivative, which can lower triglycerides and increase HDL cholesterol, but have little effect on LDL cholesterol. They are mainly used for patients with high triglyceride levels or low HDL cholesterol levels.
Choice D, amlodipine, is not an antilipidemic agent at all. It is a type of calcium channel blocker, which is used to treat hypertension and angina by relaxing the blood vessels and reducing the workload of the heart.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
According to the International Society of Hypertension, lifestyle interventions are recommended for three to six months before medication in patients with grade 1 hypertension (BP < 160/100 mm Hg) and no comorbidities.Diet and exercise can lower BP by reducing weight, sodium intake, alcohol consumption, and stress levels.
Choice A is wrong because angiotensin-converting enzyme (ACE) inhibitors are not the first-line medication for hypertension in the general population.They are preferred in patients with diabetes, chronic kidney disease, or heart failure.
Choice B is wrong because combination diuretics are not the initial recommendation for hypertension.They are used when monotherapy is not sufficient to achieve the target BP or when there is fluid retention.
Choice C is wrong because beta-adrenergic blocking agents are not the first-line medication for hypertension in the general population.They are preferred in patients with ischemic heart disease, heart failure, or arrhythmias.
Correct Answer is D
Explanation
Alpha 1 adrenergic blocking agents have a vasodilating effect and can be used for the management of hypertension. They work by blocking the alpha 1 receptors on the vascular smooth muscle, which normally cause vasoconstriction when stimulated by catecholamines like epinephrine and norepinephrine.By preventing this constriction, alpha 1 blockers lower the peripheral resistance and blood pressure
Choice A is wrong because alpha 3 adrenergic blockers do not exist.There are only two types of alpha receptors: alpha 1 and alpha 2
Choice B is wrong because alpha 2 adrenergic antagonists do not have a vasodilating effect.
They block the alpha 2 receptors, which are located presynaptically on the sympathetic nerve terminals and postsynaptically on some vascular smooth muscle cells.Alpha 2 receptors inhibit the release of norepinephrine when activated, so blocking them would increase the sympathetic activity and vasoconstriction
Choice C is wrong because alpha 1 adrenergic agonists do not have a vasodilating effect.
They stimulate the alpha 1 receptors, which cause vasoconstriction and increase the blood pressure.Alpha 1 agonists are used to treat hypotension and nasal congestion
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