What is the main reason why a woman who is older than 35 years may have difficulty achieving pregnancy?

Choice A reason: Maternal placenta previa is not a common complication of gestational diabetes mellitus. Placenta previa is a condition in which the placenta covers the cervix, which can cause bleeding and preterm labor. The risk factors for placenta previa include previous cesarean delivery, multiple pregnancy, advanced maternal age, and smoking.

Choice B reason: Maternal hyperemesis and neonatal low birth weight are not directly related to gestational diabetes mellitus. Hyperemesis is a severe form of nausea and vomiting during pregnancy that can cause dehydration and weight loss. The causes of hyperemesis are not well understood, but it may be influenced by hormonal changes, genetic factors, and psychological factors². Neonatal low birth weight is defined as a birth weight of less than 2,500 grams, which can be caused by many factors, such as prematurity, intrauterine growth restriction, maternal infection, and maternal malnutrition.

Choice C reason: Maternal premature rupture of membranes and neonatal sepsis are not specific to gestational diabetes mellitus. Premature rupture of membranes is a condition in which the amniotic sac breaks before labor begins, which can increase the risk of infection and preterm delivery. The causes of premature rupture of membranes are not clear, but some possible factors include infection, inflammation, stress, and trauma. Neonatal sepsis is a life-threatening infection in newborns, which can be caused by bacteria, viruses, or fungi. The risk factors for neonatal sepsis include prematurity, low birth weight, maternal infection, and invasive procedures⁵.

Choice D reason: Maternal preeclampsia and fetal macrosomia are the most common and serious complications of gestational diabetes mellitus. Preeclampsia is a condition characterized by high blood pressure and protein in the urine, which can lead to organ damage, seizures, and death. The exact cause of preeclampsia is unknown, but it may be related to abnormal placental development, immune system dysfunction, and genetic factors⁶. Fetal macrosomia is a condition in which the baby is larger than normal, usually weighing more than 4,000 grams at birth. This can cause difficulties during labor and delivery, such as shoulder dystocia, birth trauma, and cesarean section. The main cause of fetal macrosomia is excessive maternal glucose, which stimulates fetal insulin production and growth.

Choice A reason: Biophysical profile is a test that assesses the fetal well-being by measuring five parameters: fetal breathing movements, fetal movements, fetal tone, amniotic fluid volume, and fetal heart rate. It does not predict chromosomal abnormalities in the fetus.

Choice B reason: Lecithin/sphingomyelin [L/S] ratio is a test that measures the amount of two phospholipids in the amniotic fluid. It is used to evaluate the fetal lung maturity and the risk of respiratory distress syndrome. It does not predict chromosomal abnormalities in the fetus.

Choice C reason: Type and crossmatch of maternal and fetal serum is a test that determines the blood type and Rh factor of the mother and the fetus. It is used to identify the risk of hemolytic disease of the newborn due to Rh incompatibility. It does not predict chromosomal abnormalities in the fetus.

Choice D reason: Multiple-marker screening is a test that measures the levels of four substances in the maternal serum: alpha-fetoprotein, human chorionic gonadotropin, unconjugated estriol, and inhibin A. It is used to estimate the risk of Down syndrome, trisomy 18, and neural tube defects in the fetus.