Systemic lupus erythematosus is an example of which type of hypersensitivity reaction?
Type IV
Type III
Type II
Type I
The Correct Answer is B
A. Type IV Hypersensitivity (Delayed Hypersensitivity Reaction): This type of reaction involves a delayed immune response, typically occurring 24 to 72 hours after exposure to an antigen. It's characterized by the activation of T cells and macrophages, leading to inflammation. This type of hypersensitivity is often associated with conditions like contact dermatitis and some autoimmune diseases.
B. Type III Hypersensitivity (Antibody-Mediated Reaction): Type III hypersensitivity reactions occur when immune complexes, which are composed of antigens and antibodies, deposit in various tissues. This leads to inflammation and tissue damage. Systemic lupus erythematosus (SLE) is an example of a disease associated with Type III hypersensitivity.
C. Type II Hypersensitivity: This type of reaction involves antibodies (IgG or IgM) targeting antigens on the surface of cells. This can lead to cell destruction through various mechanisms, such as complement activation or antibody-dependent cell-mediated cytotoxicity (ADCC). Examples include hemolytic transfusion reactions and autoimmune hemolytic anemia.
D. Type I Hypersensitivity (Immediate Hypersensitivity Reaction): Type I hypersensitivity is characterized by an immediate immune response, typically occurring within minutes of exposure to an allergen. It involves the release of histamines and other mediators from mast cells and basophils, leading to symptoms like hives, respiratory distress, and anaphylaxis. Allergies, like hay fever and food allergies, are examples of Type I hypersensitivity reactions.
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Related Questions
Correct Answer is ["B","D"]
Explanation
A. Hypertension: Anaphylaxis often leads to a rapid drop in blood pressure (hypotension) rather than hypertension. Hypotension is a more common symptom because of the severe vasodilation that occurs during anaphylactic reactions.
B. Angioedema: Yes, angioedema is a common clinical manifestation of anaphylaxis. Angioedema involves swelling of the deeper layers of the skin, often around the eyes and lips. It can also affect the throat, which can be life-threatening due to airway obstruction.
C. Petechiae: Petechiae are small red or purple spots that appear on the skin and are caused by bleeding into the skin's tissues. They are not a typical manifestation of anaphylaxis.
D. Bronchospasm: Yes, bronchospasm is a hallmark clinical manifestation of anaphylaxis. It involves the sudden constriction of the airways, leading to difficulty in breathing and wheezing.
Correct Answer is ["A","B","C","D"]
Explanation
A. Viral Latency: Some viruses, like herpesviruses, can enter a latent phase where they hide in host cells, making it challenging for the immune system to detect and target them.
B. Host Defense Failure: This term encompasses situations where the host's defense mechanisms, including physical barriers and immune responses, are not effective in preventing or controlling infection. For example, pathogens may develop mechanisms to evade detection by the immune system.
C. Immunosuppression: Pathogens can actively suppress the host's immune response. They may produce molecules or proteins that inhibit the immune system's ability to mount an effective defense.
D. Immunodeficiency: Individuals with immunodeficiency disorders have weakened immune systems, which can be congenital (genetic) or acquired. This weakness makes them more susceptible to infections.
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