A nurse is to administer Dobutamine (Dobutrex) 2.5 mcg/kg/min IV to a patient with severe heart failure who weighs 130 pounds. The pharmacy prepares a solution of 250 mg of Dobutrex in 500 mL D5W. How many mL of the medication should be administered to the patient per hour? Round your answer to the nearest whole number.

Assessing tissue perfusion is crucial in evaluating the adequacy of oxygen and nutrient delivery to the body's tissues. While multiple factors contribute to tissue perfusion, the options provided in choice B are key indicators:
Level of consciousness: Altered mental status or changes in the patient's level of consciousness can be a sign of impaired cerebral perfusion, which reflects overall tissue perfusion.
Urine output: Monitoring urine output provides information about renal perfusion and kidney function. Decreased urine output can be indicative of inadequate tissue perfusion.
Lactate level: Lactate is a by-product of anaerobic metabolism that accumulates when there is insufficient oxygen delivery to tissues. Elevated lactate levels indicate tissue hypoperfusion and cellular oxygen debt.

A. Pupil response, pulse pressure, and urine output in (option A) are incorrect because While pupil response and pulse pressure may provide some information about perfusion, they do not encompass a comprehensive assessment of tissue perfusion. Additionally, assessing urine output is important, but it alone may not provide a complete picture of tissue perfusion status.
C. Blood pressure, pulse, and respirations in (option C) are incorrect because Blood pressure, pulse, and respirations are important vital signs to monitor, but they do not solely indicate tissue perfusion. Hypotension, for example, can be a late sign of inadequate tissue perfusion.
D. Breath sounds, heart rate, and pupil response in (option D) are incorrect because: Although breath sounds and heart rate can be affected by changes in tissue perfusion, they are not specific or comprehensive indicators of tissue perfusion status. Pupil response alone does not provide a complete assessment of tissue perfusion.
Therefore, the most accurate assessment of tissue perfusion in a patient in shock involves evaluating the level of consciousness, urine output, and lactate levels.

Mean arterial pressure (MAP) is a measure of the average pressure within the arteries during one cardiac cycle. It represents the perfusion pressure that drives blood flow to organs and tissues. MAP is calculated using the formula:
MAP = Diastolic blood pressure + 1/3 (Systolic blood pressure - Diastolic blood pressure)
Blood loss, particularly in cases of significant hemorrhage, leads to a decrease in blood volume. When blood volume decreases, there is less circulating blood available to generate pressure within the arterial system. This reduction in blood volume results in decreased MAP.
Therefore, in the case of massive blood loss after trauma, the student can correlate it with a lower blood volume, which in turn leads to a lower MAP. The decrease in blood volume reduces the perfusion pressure, compromising organ and tissue perfusion
A. It causes vasoconstriction and increased MAP in (option A) is incorrect because: While vasoconstriction can occur as a compensatory mechanism to maintain blood pressure, it does not necessarily lead to an increased MAP in the context of significant blood loss.
C. It raises cardiac output and MAP in (option C) is incorrect because Blood loss typically leads to a reduction in cardiac output due to decreased blood volume. Therefore, it does not raise cardiac output and MAP.
D. There is no direct correlation to MAP in (option D) is incorrect because: There is indeed a direct correlation between blood loss and MAP. As blood volume decreases, MAP decreases as well.
Therefore, the correct correlation between blood loss and MAP is that lower blood volume lowers MAP.