Which statement indicates a correct understanding of topical drug absorption in a pediatric patient?.
Because the skin is not fully hydrated at this age, water-soluble drugs are not readily absorbed.
Inflammation decreases the amount of drug absorbed.
Topical administration with percutaneous absorption is usually effective in infants.
Infants wearing plastic-coated diapers are more susceptible to skin absorption.
The Correct Answer is D
Choice A rationale:
While it’s true that hydration affects skin absorption, it’s not accurate to say that water-soluble drugs are not readily absorbed because the skin is not fully hydrated.
Choice B rationale:
Inflammation can actually increase the amount of drug absorbed due to increased blood flow and permeability.
Choice C rationale:
Topical administration with percutaneous absorption can be effective in infants, but it’s not always the case.
Choice D rationale:
Infants wearing plastic-coated diapers are indeed more susceptible to skin absorption. This is because the occlusive nature of the diaper can enhance absorption by increasing the hydration of the skin.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
Choice A rationale:
Decreased splanchnic blood flow can affect drug absorption and metabolism, but it does not directly increase the risk of gastric irritation from NSAIDs.
Choice B rationale:
Prolonged secretion of gastric acid can contribute to conditions like gastroesophageal reflux disease (GERD), but it is not the primary factor increasing the risk of gastric irritation from NSAIDs in older adults.
Choice C rationale:
Delayed gastric emptying is the correct answer. It allows drugs to stay in contact with the stomach lining for a longer time, which can increase the risk of gastric irritation from NSAIDs.
Choice D rationale:
Loss of cells from the gastric plexus can affect gastric function, but it is not directly linked to an increased risk of gastric irritation from NSAIDs.
Correct Answer is D
Explanation
Choice A rationale:
While it’s true that hydration affects skin absorption, it’s not accurate to say that water-soluble drugs are not readily absorbed because the skin is not fully hydrated.
Choice B rationale:
Inflammation can actually increase the amount of drug absorbed due to increased blood flow and permeability.
Choice C rationale:
Topical administration with percutaneous absorption can be effective in infants, but it’s not always the case.
Choice D rationale:
Infants wearing plastic-coated diapers are indeed more susceptible to skin absorption. This is because the occlusive nature of the diaper can enhance absorption by increasing the hydration of the skin.
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