A nurse is preparing to administer levothyroxine 100 mcg PO to a client who has hypothyroidism.

Available is levothyroxine 50 mcg tablets.

How many tablets should the nurse administer?
(Round the answer to the nearest whole number. Use a leading zero if it applies. Do not use a trailing zero.)

Choice A rationale:
While distribution can affect a person’s response to medication, it is not the aspect of genetic makeup most likely to alter this response.
Choice B rationale:
Absorption can affect how a drug is taken up by the body, but it is not the aspect of genetic makeup most likely to alter a person’s response to medication.
Choice C rationale:
Excretion, or how the body eliminates a drug, can affect drug response, but it is not the aspect of genetic makeup most likely to alter this response.
Choice D rationale:
Metabolism, or how the body processes a drug, is the aspect of genetic makeup most likely to alter a person’s response to medication. Genetic differences can lead to variations in drug-metabolizing enzymes, affecting how quickly or slowly drugs are metabolized.

Step 1 is to determine the amount of amoxicillin in each mL of the solution. This is done by dividing the total amount of amoxicillin in the solution (250 mg) by the total volume of the solution (5 mL). So, 250 mg ÷ 5 mL = 50 mg/mL. Step 2 is to determine how many mL of the solution is needed to administer 300 mg of amoxicillin.

This is done by dividing the desired dose (300 mg) by the amount of amoxicillin per mL (50 mg/mL). So, 300 mg ÷ 50 mg/mL = 6 mL.

So, the nurse should administer 6 mL of the amoxicillin oral solution. .