A nurse is preparing to administer levothyroxine 100 mcg PO to a client who has hypothyroidism.

Available is levothyroxine 50 mcg tablets.

How many tablets should the nurse administer?
(Round the answer to the nearest whole number. Use a leading zero if it applies. Do not use a trailing zero.)

Choice A rationale:
The patient reporting a sore throat after taking his regular medications is subjective information because it is based on the patient’s personal experience and feelings.
Choice B rationale:
The patient’s daughter stating her father often forgets to take his medication is also subjective information as it is based on the daughter’s observations and perceptions.
Choice C rationale:
The patient stating he feels dizzy whenever he takes his medication is subjective information because it is based on the patient’s personal experience and feelings.
Choice D rationale:
The patient stating that his temperature has been 88.8F is objective information because it is a measurable fact.

Choice A rationale:
Protein binding does not inactivate the drug. Instead, it can affect the drug’s distribution and bioavailability.
Choice B rationale:
Protein binding does not directly increase the risk of an allergic reaction. Allergic reactions are typically immune responses to a drug, not a result of protein binding.
Choice C rationale:
An idiosyncratic reaction is an unusual or unexpected reaction to a drug, which is not related to protein binding.
Choice D rationale:
Protein binding can lead to the accumulation of the drug. Drugs often cannot cross membranes mainly due to the high molecular mass of the drug-protein complex, resulting in the accumulation of the active compounds.