Which principle of pharmacokinetics must the nurse keep in mind when administering medication to an infant?.
Metabolism of drug by the kidneys is slower, so reduced dosage is needed.
Absorption of oral medications is more predictable but more rapid than in adults.
There's an increased risk of toxicity with use of topical agents.
Protein binding of drugs is greater than in adults.
The Correct Answer is C
Choice A rationale:
While it’s true that infants have slower drug metabolism, this is generally due to liver immaturity, not kidney function.
Choice B rationale:
Absorption of oral medications in infants can be unpredictable due to their immature digestive systems.
Choice C rationale:
Infants do have an increased risk of toxicity with the use of topical agents because their skin is thinner and more permeable.
Choice D rationale:
Protein binding of drugs is actually less in infants than in adults, not greater.
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Related Questions
Correct Answer is C
Explanation
Choice A rationale:
While it’s true that infants have slower drug metabolism, this is generally due to liver immaturity, not kidney function.
Choice B rationale:
Absorption of oral medications in infants can be unpredictable due to their immature digestive systems.
Choice C rationale:
Infants do have an increased risk of toxicity with the use of topical agents because their skin is thinner and more permeable.
Choice D rationale:
Protein binding of drugs is actually less in infants than in adults, not greater.
Correct Answer is A
Explanation
Choice A rationale:
Women experience more problems than men when taking aspirin due to Gastric acidity. Aspirin can cause gastric irritation, and women have been found to have higher gastric acidity than men.
Choice B rationale:
Levels of hepatic enzyme do not specifically cause women to have more problems with aspirin than men. These enzymes are involved in drug metabolism, but their levels do not differ significantly between genders.
Choice C rationale:
Amounts of alcohol dehydrogenase do not cause more problems for women when taking aspirin. This enzyme is involved in alcohol metabolism, not aspirin.
Choice D rationale:
Decreased gastric emptying can increase the risk of gastric irritation from nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin in older adults, but it’s not a gender-specific factor.
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