Which effect of protein binding on drugs in the bloodstream is accurate?.
Inactivation of the drug.
Increased risk of allergic reaction.
Precipitation of an idiosyncratic reaction.
Accumulation of the drug.
The Correct Answer is D
Choice A rationale:
Protein binding does not inactivate the drug. Instead, it can affect the drug’s distribution and bioavailability.
Choice B rationale:
Protein binding does not directly increase the risk of an allergic reaction. Allergic reactions are typically immune responses to a drug, not a result of protein binding.
Choice C rationale:
An idiosyncratic reaction is an unusual or unexpected reaction to a drug, which is not related to protein binding.
Choice D rationale:
Protein binding can lead to the accumulation of the drug. Drugs often cannot cross membranes mainly due to the high molecular mass of the drug-protein complex, resulting in the accumulation of the active compounds.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Choice A rationale:
An increase in the amount of lipid-soluble drugs in the system can occur with decreased albumin and globulin levels, but it does not cause the most concern.
Choice B rationale:
Increased free protein-bound drugs available can lead to an increased potential for adverse drug reactions. This is because these drugs are usually more active and can lead to toxicity.
Choice C rationale:
Water-soluble drugs being absorbed more completely is not typically a concern with decreased albumin and globulin levels.
Choice D rationale:
While metabolism of protein-bound drugs may be decreased, leading to an increased potential for adverse reactions, this is not the primary concern with decreased albumin and globulin levels.
Correct Answer is C
Explanation
Choice A rationale:
The term “Aged” generally refers to individuals who are in the late stages of life, often those over 652. This does not apply to a 40-year-old patient.
Choice B rationale:
“Elderly” is a term often used to refer to individuals who are 65 years of age or older. A 40-year-old patient does not fall into this category.
Choice C rationale:
A 40-year-old patient is considered an “Adult”. According to Erikson’s stages of development, the stage of “generativity vs. stagnation” begins at age 40 and lasts until age 653.
Choice D rationale:
“Older adult” typically refers to individuals who are in their late 60s and beyond. This does not apply to a 40-year-old patient.
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