A patient is taking an antacid concurrently with ketoconazole.

The antacid inhibits the dissolution of ketoconazole.

Which term accurately describes this result?.

Choice A rationale:
An allergic reaction refers to an immune response to a foreign substance. It does not describe the interaction between an antacid and ketoconazole.
Choice B rationale:
Displacement refers to one drug replacing another at the drug-binding site on proteins, altering the distribution of the displaced drug. It does not describe the interaction between an antacid and ketoconazole.
Choice C rationale:
Accumulation refers to the buildup of a drug in the body due to inadequate metabolism or excretion. It does not describe the interaction between an antacid and ketoconazole.
Choice D rationale:
A drug interaction occurs when the effect of one drug is altered by the administration of another drug. Antacids can slow the dissolution and absorption of ketoconazole, which is a type of drug interaction.

Choice A rationale:

Absorption is not primarily affected by the functioning of hepatic enzymes.

Choice B rationale:

Distribution is not the main concern when dealing with abnormal functioning of hepatic enzymes.

Choice C rationale:

Excretion is mainly a function of the kidneys, not the liver.

Choice D rationale:

Metabolism is the aspect of pharmacokinetics most affected by the functioning of hepatic enzymes. The liver plays a crucial role in the metabolism of drugs.