Which of the following side effects is associated with the blockade of attachment of norepinephrine to alpha-1 receptors?
Orthostatic hypotension
Increased psychotic symptoms
Severe appetite disturbance
Hypertensive crisis
The Correct Answer is A
Choice A reason: Blocking norepinephrine at alpha-1 receptors inhibits vasoconstriction, reducing vascular tone. This disrupts baroreceptor-mediated blood pressure regulation, causing orthostatic hypotension when standing. The autonomic nervous system fails to compensate for positional changes, leading to dizziness and fainting, a common side effect of alpha-1 blockers like prazosin.
Choice B reason: Increased psychotic symptoms are linked to dopamine dysregulation, not alpha-1 receptor blockade. Norepinephrine blockade affects autonomic functions, not psychosis, which involves mesolimbic dopamine hyperactivity. This side effect is unrelated to alpha-1 receptors, making this option scientifically inaccurate for the described mechanism.
Choice C reason: Appetite disturbance is typically associated with serotonin or histamine receptor effects, not alpha-1 norepinephrine blockade. Norepinephrine at alpha-1 receptors regulates vascular tone, not appetite control, which involves hypothalamic signaling. This side effect is not a direct consequence of alpha-1 blockade, rendering this option incorrect.
Choice D reason: Hypertensive crisis results from excessive norepinephrine activity, often due to monoamine oxidase inhibitors, not alpha-1 receptor blockade. Blocking alpha-1 receptors causes vasodilation, lowering blood pressure, not raising it. This makes hypertensive crisis an unlikely side effect, contrary to the pharmacological mechanism of alpha-1 blockers.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Choice A reason: Process recordings are for nurse self-reflection, not client analysis. They examine nurse communication, not patient abnormalities. Client communication issues, like disorganized speech in schizophrenia, are assessed clinically, not via recordings, making this option incorrect for the tool’s purpose in psychiatric practice.
Choice B reason: Process recordings analyze the nurse’s communication impact, assessing verbal and nonverbal cues on client responses. Effective communication, processed via mirror neurons, fosters therapeutic alliances, calming amygdala-driven anxiety. This self-evaluation improves nurse effectiveness, aligning with the scientific purpose of process recordings in psychiatric care.
Choice C reason: Identifying client communication abnormalities is a clinical assessment task, not the purpose of process recordings. Recordings focus on nurse interactions, not patient speech patterns, like those in mania. This option misaligns with the tool’s introspective goal, making it incorrect for its intended use.
Choice D reason: Clients exploring alternate techniques is a therapeutic goal, not the purpose of process recordings. Recordings analyze nurse communication, not patient skill-building. Effective nurse responses can reduce stress-related cortisol spikes, but this is secondary, making this option incorrect for the recording’s primary purpose.
Correct Answer is A
Explanation
Choice A reason: Paroxetine, an SSRI, is first-line for GAD, enhancing serotonin in the amygdala and prefrontal cortex, reducing excessive worry. Its efficacy and tolerability, with minimal dependence risk, align with evidence-based guidelines for long-term anxiety management, making it the preferred choice.
Choice B reason: Imipramine, a tricyclic antidepressant, affects serotonin and norepinephrine but has significant anticholinergic side effects, reducing tolerability. It is not first-line for GAD due to slower onset and side effect profile compared to SSRIs, which better target anxiety’s neurobiological basis.
Choice C reason: Hydroxyzine, an antihistamine, reduces anxiety via histamine receptor blockade, causing sedation. It is used as needed, not for chronic GAD management. SSRIs, like paroxetine, offer sustained serotonin modulation, making hydroxyzine a less effective, non-first-line option for long-term treatment.
Choice D reason: Alprazolam, a benzodiazepine, enhances GABA activity, providing rapid anxiety relief but carries high dependence risk. It is not first-line for GAD, as SSRIs offer safer, long-term serotonin-based treatment, making alprazolam unsuitable for chronic management due to addiction potential.
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