Which of the following side effects is associated with the blockade of attachment of norepinephrine to alpha-1 receptors?
Orthostatic hypotension
Increased psychotic symptoms
Severe appetite disturbance
Hypertensive crisis
The Correct Answer is A
Choice A reason: Blocking norepinephrine at alpha-1 receptors inhibits vasoconstriction, reducing vascular tone. This disrupts baroreceptor-mediated blood pressure regulation, causing orthostatic hypotension when standing. The autonomic nervous system fails to compensate for positional changes, leading to dizziness and fainting, a common side effect of alpha-1 blockers like prazosin.
Choice B reason: Increased psychotic symptoms are linked to dopamine dysregulation, not alpha-1 receptor blockade. Norepinephrine blockade affects autonomic functions, not psychosis, which involves mesolimbic dopamine hyperactivity. This side effect is unrelated to alpha-1 receptors, making this option scientifically inaccurate for the described mechanism.
Choice C reason: Appetite disturbance is typically associated with serotonin or histamine receptor effects, not alpha-1 norepinephrine blockade. Norepinephrine at alpha-1 receptors regulates vascular tone, not appetite control, which involves hypothalamic signaling. This side effect is not a direct consequence of alpha-1 blockade, rendering this option incorrect.
Choice D reason: Hypertensive crisis results from excessive norepinephrine activity, often due to monoamine oxidase inhibitors, not alpha-1 receptor blockade. Blocking alpha-1 receptors causes vasodilation, lowering blood pressure, not raising it. This makes hypertensive crisis an unlikely side effect, contrary to the pharmacological mechanism of alpha-1 blockers.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Choice A reason: Process recordings are for nurse self-reflection, not client analysis. They examine nurse communication, not patient abnormalities. Client communication issues, like disorganized speech in schizophrenia, are assessed clinically, not via recordings, making this option incorrect for the tool’s purpose in psychiatric practice.
Choice B reason: Process recordings analyze the nurse’s communication impact, assessing verbal and nonverbal cues on client responses. Effective communication, processed via mirror neurons, fosters therapeutic alliances, calming amygdala-driven anxiety. This self-evaluation improves nurse effectiveness, aligning with the scientific purpose of process recordings in psychiatric care.
Choice C reason: Identifying client communication abnormalities is a clinical assessment task, not the purpose of process recordings. Recordings focus on nurse interactions, not patient speech patterns, like those in mania. This option misaligns with the tool’s introspective goal, making it incorrect for its intended use.
Choice D reason: Clients exploring alternate techniques is a therapeutic goal, not the purpose of process recordings. Recordings analyze nurse communication, not patient skill-building. Effective nurse responses can reduce stress-related cortisol spikes, but this is secondary, making this option incorrect for the recording’s primary purpose.
Correct Answer is D
Explanation
Choice A reason: Buspirone enhances serotonin activity, taking weeks to reduce anxiety. Panic attacks, driven by acute norepinephrine surges in the amygdala, require rapid intervention. Buspirone’s delayed onset makes it ineffective for acute symptom relief, unlike fast-acting options targeting immediate neurochemical imbalances.
Choice B reason: Venlafaxine, an SNRI, increases serotonin and norepinephrine over weeks, unsuitable for acute panic attacks. Panic involves rapid sympathetic activation, requiring immediate GABA enhancement or similar fast-acting mechanisms, not gradual reuptake inhibition, making venlafaxine incorrect for rapid relief.
Choice C reason: Imipramine, a tricyclic, modulates serotonin and norepinephrine but takes weeks to act. Acute panic, driven by locus coeruleus norepinephrine spikes, needs immediate relief. Imipramine’s slow onset and side effects make it inappropriate for rapid intervention in acute anxiety episodes.
Choice D reason: Alprazolam, a benzodiazepine, enhances GABA-A receptor activity, rapidly inhibiting excessive neural firing in the amygdala during panic attacks. This provides quick relief from acute anxiety symptoms, like tachycardia, within minutes, making it the correct choice for immediate neurobiological stabilization in panic episodes.
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