Which of the following side effects is associated with the blockade of attachment of norepinephrine to alpha-1 receptors?
Orthostatic hypotension
Increased psychotic symptoms
Severe appetite disturbance
Hypertensive crisis
The Correct Answer is A
Choice A reason: Blocking norepinephrine at alpha-1 receptors inhibits vasoconstriction, reducing vascular tone. This disrupts baroreceptor-mediated blood pressure regulation, causing orthostatic hypotension when standing. The autonomic nervous system fails to compensate for positional changes, leading to dizziness and fainting, a common side effect of alpha-1 blockers like prazosin.
Choice B reason: Increased psychotic symptoms are linked to dopamine dysregulation, not alpha-1 receptor blockade. Norepinephrine blockade affects autonomic functions, not psychosis, which involves mesolimbic dopamine hyperactivity. This side effect is unrelated to alpha-1 receptors, making this option scientifically inaccurate for the described mechanism.
Choice C reason: Appetite disturbance is typically associated with serotonin or histamine receptor effects, not alpha-1 norepinephrine blockade. Norepinephrine at alpha-1 receptors regulates vascular tone, not appetite control, which involves hypothalamic signaling. This side effect is not a direct consequence of alpha-1 blockade, rendering this option incorrect.
Choice D reason: Hypertensive crisis results from excessive norepinephrine activity, often due to monoamine oxidase inhibitors, not alpha-1 receptor blockade. Blocking alpha-1 receptors causes vasodilation, lowering blood pressure, not raising it. This makes hypertensive crisis an unlikely side effect, contrary to the pharmacological mechanism of alpha-1 blockers.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Choice A reason: Justice ensures fair treatment across patients. Different interventions (restraint vs. supervision) for self-mutilation, possibly due to serotonin dysregulation, must be equitably applied based on clinical need, not bias. Ensuring consistent, fair application of interventions aligns with justice, addressing ethical concerns about differential treatment in psychiatric care.
Choice B reason: Autonomy involves respecting patient choices, but self-mutilation, driven by impulsivity or emotional dysregulation, requires safety interventions overriding choice. Restraint and supervision prioritize safety over autonomy, making this principle less relevant than justice, which focuses on equitable treatment across patients in this scenario.
Choice C reason: Fidelity emphasizes keeping promises or loyalty to patients, not the fairness of intervention choices. While trust is crucial, the concern here is equitable treatment for self-mutilation, not commitment to promises. Fidelity is secondary to justice in addressing differential interventions, making it incorrect.
Choice D reason: Beneficence focuses on doing good, like preventing harm in self-mutilation. Both restraint and supervision aim to protect, but the ethical concern is fairness, not benefit. Justice addresses equitable application of interventions, making beneficence less directly applicable to the ethical dilemma described.
Correct Answer is A
Explanation
Choice A reason: Sullivan’s interpersonal theory emphasizes therapeutic relationships and social environments to foster mental health. The therapeutic milieu, structured to promote safety and interaction, aligns with Sullivan’s focus on interpersonal dynamics, reducing symptoms like anxiety through supportive settings, which stabilize neurotransmitter imbalances, enhancing patient recovery on psychiatric units.
Choice B reason: Sullivan’s theory does not focus on age-appropriate versus arrested behaviors. It emphasizes interpersonal relationships, not developmental stages. Assessment tools for behavior typically rely on other frameworks, like Erikson’s, which address developmental milestones, not Sullivan’s interpersonal model, making this option scientifically inaccurate for the theory’s application.
Choice C reason: Restraint and seclusion are not part of Sullivan’s theory, which promotes therapeutic relationships to reduce anxiety, not coercive measures. These interventions contradict Sullivan’s focus on supportive environments, as they may exacerbate stress and neurotransmitter dysregulation, such as increased cortisol, worsening mental health outcomes in psychiatric settings.
Choice D reason: The nursing process is a general framework, not specific to Sullivan’s theory. Sullivan’s interpersonal model focuses on relationships to alleviate symptoms, not on sequencing nursing actions. While the nursing process guides care, it is not derived from Sullivan’s principles, making this option unrelated to his theoretical application.
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