Which of the following is both the standard treatment and also a potential cure for aplastic anemia?

A. The patient experiences a decrease in hemoglobin S. Hydroxyurea does not decrease hemoglobin S levels directly; it works by increasing fetal hemoglobin (Hgb F) levels.
B. The patient experiences dehydration due to diuresis. This is not an indication that Hydroxyurea is working; it is a potential side effect that should be monitored.
C. The patient experiences an increase in fetal hemoglobin (Hbg F). Hydroxyurea works by increasing the levels of fetal hemoglobin, which reduces the sickling of red blood cells.
D. The patient needs fewer blood transfusions. Successful treatment with Hydroxyurea should reduce the frequency of vaso-occlusive crises and the need for blood transfusions.
E. The patient experiences diuresis. This is not an indicator of the medication's effectiveness; it is a potential side effect.

A. Severe pain in the abdomen and joints. Severe pain is the hallmark symptom of a sickle cell crisis, often occurring in the abdomen, joints, and bones due to vaso-occlusive events.
B. Fever and chills. While fever can be a sign of infection in individuals with sickle cell disease, it is not the most common symptom during a sickle cell crisis.
C. Cough and shortness of breath. These symptoms are more indicative of respiratory infections or complications like acute chest syndrome but are not the primary symptoms of a sickle cell crisis.
D. Numbness and tingling in the extremities. These symptoms are not typically associated with a sickle cell crisis.