Which of the following is a potential complication of primary immunodeficiency disorders?
Hypertension
Chronic fatigue syndrome
Autoimmune diseases
Diabetes mellitus
The Correct Answer is C
Explanation: The correct answer is c. Autoimmune diseases are a potential complication of primary immunodeficiency disorders. When the immune system is deficient or dysfunctional, it may fail to distinguish between self and non-self antigens, leading to the development of autoimmune diseases.
Incorrect choices:
a. Hypertension is a condition characterized by high blood pressure and is not directly related to primary immunodeficiency disorders.
b. Chronic fatigue syndrome is a complex disorder with unknown causes and is not directly related to primary immunodeficiency disorders.
d. Diabetes mellitus is a metabolic disorder caused by insufficient insulin production or insulin resistance and is not directly related to primary immunodeficiency disorders.
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Correct Answer is C
Explanation
The correct answer is c. Ataxia-telangiectasia. Ataxia-telangiectasia is a rare genetic disorder that affects the cerebellum, causing poor muscle coordination (ataxia) and small, dilated blood vessels (telangiectasias). It also leads to defective T-cell function, making affected individuals more susceptible to infections.
Incorrect choices:
a. X-linked agammaglobulinemia (XLA) is a primary immunodeficiency disorder that primarily affects B-cell function, leading to a lack of mature B cells and low levels of immunoglobulins, but does not involve defective T-cell function.
b. Selective immunoglobulin A (IgA) deficiency is characterized by a deficiency of IgA, but it does not typically lead to defective T-cell function.
d. DiGeorge syndrome is caused by a deletion on chromosome 22 and primarily affects the development of certain organs, including the thymus and parathyroid glands, resulting in T-cell deficiency. While it may lead to some B-cell abnormalities, defective T-cell function is the hallmark of this disorder.
Correct Answer is D
Explanation
Explanation: The correct answer is d. Abdominal pain and diarrhea. Abdominal pain and diarrhea are common clinical manifestations of immunodeficiency disorders. The weakened immune system makes the child more susceptible to gastrointestinal infections, leading to these symptoms.
Incorrect choices:
a. Rash and hives are more common clinical manifestations of allergic reactions or immune hypersensitivity disorders, not immunodeficiency disorders.
b. Rapid weight loss may be seen in conditions like malnutrition or metabolic disorders but is not a typical clinical manifestation of immunodeficiency disorders.
c. Excessive thirst and frequent urination are clinical manifestations of diabetes or other endocrine disorders, not immunodeficiency disorders.
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