Which of the following clinical manifestations is a common symptom of primary immunodeficiency disorders?

Explanation: The correct answer is c. Common variable immunodeficiency (CVID) is characterized by a deficiency or absence of B cells, leading to a reduced ability to produce antibodies and an increased susceptibility to infections.

Incorrect choices:

a. DiGeorge syndrome is a disorder caused by a genetic defect resulting in the underdevelopment of the thymus and parathyroid glands, leading to T cell deficiency.

b. Severe combined immunodeficiency (SCID) is a severe form of immunodeficiency that affects both B and T cells, leading to a complete absence or dysfunction of the immune system.

d. Wiskott-Aldrich syndrome is a rare X-linked genetic disorder characterized by a triad of symptoms, including eczema, low platelet count, and immunodeficiency. It primarily affects T cells and platelets, not B cells.

Explanation: The correct answer is d. Abdominal pain and diarrhea. Abdominal pain and diarrhea are common clinical manifestations of immunodeficiency disorders. The weakened immune system makes the child more susceptible to gastrointestinal infections, leading to these symptoms.

Incorrect choices:

a. Rash and hives are more common clinical manifestations of allergic reactions or immune hypersensitivity disorders, not immunodeficiency disorders.

b. Rapid weight loss may be seen in conditions like malnutrition or metabolic disorders but is not a typical clinical manifestation of immunodeficiency disorders.

c. Excessive thirst and frequent urination are clinical manifestations of diabetes or other endocrine disorders, not immunodeficiency disorders.