Which type of immunodeficiency disorder is characterized by a lack of mature B cells and an inability to produce antibodies?
DiGeorge syndrome
X-linked agammaglobulinemia
Severe combined immunodeficiency (SCID)
Acquired immunodeficiency syndrome (AIDS)
The Correct Answer is B
Explanation: The correct answer is b. X-linked agammaglobulinemia. X-linked agammaglobulinemia is a primary immunodeficiency disorder caused by a genetic mutation that leads to the absence of mature B cells, resulting in an inability to produce antibodies (immunoglobulins). As a result, individuals with this disorder are highly susceptible to infections, especially bacterial infections.
Incorrect choices:
a. DiGeorge syndrome is a primary immunodeficiency disorder characterized by abnormalities in the development of certain organs, including the thymus, leading to impaired T cell function.
c. Severe combined immunodeficiency (SCID) is a group of rare genetic disorders that affect both T cells and B cells, resulting in a severe impairment of the immune system.
d. Acquired immunodeficiency syndrome (AIDS) is a secondary immunodeficiency disorder caused by the human immunodeficiency virus (HIV) infection, which specifically targets and destroys CD4+ T cells, weakening the immune system's ability to fight infections.
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Correct Answer is C
Explanation
Explanation: The correct answer is c. X-linked agammaglobulinemia. This disorder primarily affects males and is caused by mutations in the BTK gene, resulting in a lack of mature B cells and immunoglobulins.
Incorrect choices:
a. Selective IgA deficiency is a primary immunodeficiency disorder characterized by a deficiency of immunoglobulin A (IgA), and it can affect both males and females.
b. DiGeorge syndrome is caused by a chromosome 22 deletion and is not inherited in an X-linked recessive pattern.
d. Severe combined immunodeficiency (SCID) is a group of disorders that can be inherited in various patterns, including autosomal recessive, autosomal dominant, or X-linked recessive. SCID affects both males and females and results in a severe deficiency of T cells, B cells, and natural killer (NK) cells.
Correct Answer is B
Explanation
Explanation: The correct answer is b. Recurrent skin infections. Recurrent skin infections are common clinical manifestations of immunodeficiency disorders in the elderly. The weakened immune system makes the skin more susceptible to infections and delays wound healing.
Incorrect choices:
a. Impaired balance and coordination are more commonly associated with neurological disorders or conditions affecting the musculoskeletal system, not immunodeficiency disorders.
c. Vision changes and blindness may be seen in conditions affecting the eyes or the visual system but are not typical clinical manifestations of immunodeficiency disorders.
d. Hearing loss is more commonly associated with conditions affecting the ears or the auditory system and is not a typical clinical manifestation of immunodeficiency disorders.
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