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Which of the following immunodeficiency disorders is characterized by a deficiency of immunoglobulin A (Ig

A.

a. Severe combined immunodeficiency (SCID)

B.

Common variable immunodeficiency (CVID)

C.

DiGeorge syndrome

D.

Wiskott-Aldrich syndrome

Answer and Explanation

The Correct Answer is B

Explanation: The correct answer is b. Common variable immunodeficiency (CVID). CVID is a primary immunodeficiency disorder characterized by a reduced level of immunoglobulins, particularly IgA, leading to an increased susceptibility to infections.

Incorrect choices:

a. Severe combined immunodeficiency (SCID) is a more severe immunodeficiency disorder that affects multiple components of the immune system, not specifically IgA levels.

c. DiGeorge syndrome is caused by a genetic abnormality and is characterized by a defect in the development of certain organs, including the thymus and parathyroid glands. It may result in immune system abnormalities but does not primarily involve IgA deficiency.

d. Wiskott-Aldrich syndrome is a rare X-linked genetic disorder that affects platelet function and immune system regulation but is not specifically associated with IgA deficiency.


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Related Questions

Correct Answer is A

Explanation

Explanation: The correct answer is a. Severe combined immunodeficiency (SCID). SCID is a severe and rare primary immunodeficiency disorder characterized by the absence or severe impairment of both T and B cells, leading to a profound deficiency in cellular and humoral immunity.

Incorrect choices:

b. X-linked agammaglobulinemia (XLA) primarily affects B-cell function, resulting in a lack of mature B cells and low levels of immunoglobulins, but does not typically involve T-cell deficiency.

c. Wiskott-Aldrich syndrome affects platelet function and immune system regulation, but it is not characterized by a deficiency of both T and B cells.

d. Common variable immunodeficiency (CVID) is characterized by reduced levels of immunoglobulins, particularly IgG and IgA, but it does not typically lead to a complete deficiency of both T and B cells.

Correct Answer is C

Explanation

Explanation: The correct answer is c. Failure to thrive. SCID is a severe form of immunodeficiency that affects multiple components of the immune system, leading to recurrent and severe infections and failure to thrive in affected infants.

Incorrect choices:

a. Recurrent ear infections are more commonly seen in other types of immunodeficiency disorders, such as selective IgA deficiency.

b. Chronic fatigue and lethargy may be seen in various medical conditions but are not specific to SCID.

d. Persistent joint pain is not a characteristic symptom of SCID. It may be associated with other autoimmune or inflammatory conditions.

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