Which of the following immunodeficiency disorders is characterized by a deficiency of immunoglobulin A (Ig
a. Severe combined immunodeficiency (SCID)
Common variable immunodeficiency (CVID)
DiGeorge syndrome
Wiskott-Aldrich syndrome
The Correct Answer is B
Explanation: The correct answer is b. Common variable immunodeficiency (CVID). CVID is a primary immunodeficiency disorder characterized by a reduced level of immunoglobulins, particularly IgA, leading to an increased susceptibility to infections.
Incorrect choices:
a. Severe combined immunodeficiency (SCID) is a more severe immunodeficiency disorder that affects multiple components of the immune system, not specifically IgA levels.
c. DiGeorge syndrome is caused by a genetic abnormality and is characterized by a defect in the development of certain organs, including the thymus and parathyroid glands. It may result in immune system abnormalities but does not primarily involve IgA deficiency.
d. Wiskott-Aldrich syndrome is a rare X-linked genetic disorder that affects platelet function and immune system regulation but is not specifically associated with IgA deficiency.
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Correct Answer is B
Explanation
Explanation: The correct answer is b. DiGeorge syndrome. This disorder is caused by a deletion in chromosome 22, resulting in the underdevelopment of the thymus and parathyroid glands. It leads to impaired T cell function and is associated with developmental delays, chronic infections, and autoimmune problems.
Incorrect choices:
a. X-linked agammaglobulinemia is a primary immunodeficiency disorder that primarily affects B cell function, leading to a deficiency of immunoglobulins (antibodies).
c. Wiskott-Aldrich syndrome is an X-linked recessive disorder characterized by a triad of symptoms: eczema, thrombocytopenia (low platelet count), and immunodeficiency.
d. Severe combined immunodeficiency (SCID) is a group of rare disorders characterized by a severe deficiency of T cells, B cells, and natural killer (NK) cells.
Correct Answer is C
Explanation
Explanation: The correct answer is c. Immunodeficiency disorders can lead to an increased susceptibility to infections. Immunodeficiency disorders are characterized by a weakened or impaired immune system, making individuals more susceptible to infections, both common and opportunistic.
Incorrect choices:
a. Immunodeficiency disorders result from a weakened immune system, not an overactive one. In overactive immune responses, autoimmune disorders may occur.
b. While some immunodeficiency disorders have a genetic basis, not all cases are caused by genetic factors. Some immunodeficiency disorders can be acquired later in life due to infections, medications, or other factors.
d. Immunodeficiency disorders are not typically treated with anti-inflammatory medications. Treatment may involve immunoglobulin replacement therapy, antiviral medications, or stem cell transplantation, depending on the specific disorder and its underlying cause.
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