Which of the following immunodeficiency disorders is characterized by a deficiency of immunoglobulin A (Ig
a. Severe combined immunodeficiency (SCID)
Common variable immunodeficiency (CVID)
DiGeorge syndrome
Wiskott-Aldrich syndrome
The Correct Answer is B
Explanation: The correct answer is b. Common variable immunodeficiency (CVID). CVID is a primary immunodeficiency disorder characterized by a reduced level of immunoglobulins, particularly IgA, leading to an increased susceptibility to infections.
Incorrect choices:
a. Severe combined immunodeficiency (SCID) is a more severe immunodeficiency disorder that affects multiple components of the immune system, not specifically IgA levels.
c. DiGeorge syndrome is caused by a genetic abnormality and is characterized by a defect in the development of certain organs, including the thymus and parathyroid glands. It may result in immune system abnormalities but does not primarily involve IgA deficiency.
d. Wiskott-Aldrich syndrome is a rare X-linked genetic disorder that affects platelet function and immune system regulation but is not specifically associated with IgA deficiency.
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Correct Answer is D
Explanation
Explanation: The correct answer is d. Selective IgA deficiency. This disorder is characterized by a lack of immunoglobulin A, which can lead to an increased susceptibility to infections, particularly in the respiratory and gastrointestinal tracts.
Incorrect choices:
a. Selective IgM deficiency is a rare immunodeficiency disorder characterized by a lack of immunoglobulin M (IgM), not IgA.
b. X-linked agammaglobulinemia is a primary immunodeficiency disorder caused by a mutation in the BTK gene, resulting in a deficiency of B cells and immunoglobulins.
c. Common variable immunodeficiency (CVID) is a heterogeneous group of disorders characterized by decreased levels of immunoglobulins, including IgA, IgG, and IgM.
Correct Answer is C
Explanation
Explanation: The correct answer is c. Flow cytometry. Flow cytometry is a specialized test used to analyze the different cell types in a blood sample. In the case of SCID, flow cytometry can help identify the absence or severe deficiency of T cells and B cells, which are essential components of the immune system.
Incorrect choices:
a. A tuberculin skin test (TST) is used to detect exposure to tuberculosis (TB) and is not specific to diagnosing SCID.
b. A Western blot test is a type of immunoassay used to detect specific antibodies or antigens in the blood but is not specific to diagnosing SCID.
d. Liver function tests are used to assess the health of the liver and are not specific to diagnosing SCID.
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