The nurse is reviewing the diagnostic evaluation for a client with suspected immunodeficiency disorder. Which finding would be consistent with a potential diagnosis of severe combined immunodeficiency (SCID)?

Explanation: The correct answer is c. Frequent and severe infections. Immunodeficiency disorders impair the body's ability to fight infections, leading to recurrent and severe infections. This is a hallmark sign of immunodeficiency.

Incorrect choices:

a. Hyperactivity and restlessness are not typical clinical manifestations of immunodeficiency disorders. These symptoms are more commonly associated with conditions like attention deficit hyperactivity disorder (ADHD).

b. Increased appetite and weight gain are not specific to immunodeficiency disorders. They may be seen in conditions like hypothyroidism or certain eating disorders.

d. Hypertension and tachycardia are not characteristic clinical manifestations of immunodeficiency disorders. These symptoms may be associated with cardiovascular issues.

Explanation: The correct answer is b. DiGeorge syndrome. This disorder is caused by a deletion in chromosome 22, resulting in the underdevelopment of the thymus and parathyroid glands. It leads to impaired T cell function and is associated with developmental delays, chronic infections, and autoimmune problems.

Incorrect choices:

a. X-linked agammaglobulinemia is a primary immunodeficiency disorder that primarily affects B cell function, leading to a deficiency of immunoglobulins (antibodies).

c. Wiskott-Aldrich syndrome is an X-linked recessive disorder characterized by a triad of symptoms: eczema, thrombocytopenia (low platelet count), and immunodeficiency.

d. Severe combined immunodeficiency (SCID) is a group of rare disorders characterized by a severe deficiency of T cells, B cells, and natural killer (NK) cells.