The nurse is reviewing the diagnostic evaluation for a client with suspected immunodeficiency disorder. Which finding would be consistent with a potential diagnosis of severe combined immunodeficiency (SCID)?
Increased levels of circulating B cells
Elevated immunoglobulin M (IgM) levels
Abnormal antibody response to vaccinations
Absence or significantly reduced T cell levels
The Correct Answer is D
Explanation: The correct answer is d. Absence or significantly reduced T cell levels. Severe combined immunodeficiency (SCID) is characterized by a severe deficiency or absence of T cells, which are essential for cell-mediated immunity.
Incorrect choices:
a. Increased levels of circulating B cells are not characteristic of SCID. In SCID, both T and B cell immunity are affected, and the client may have reduced levels of both.
b. Elevated immunoglobulin M (IgM) levels may occur in certain types of immunodeficiency disorders, but it is not a specific finding for SCID.
c. Abnormal antibody response to vaccinations can be observed in various immunodeficiency disorders, but it does not specifically indicate SCID.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
Explanation: The correct answer is c. Common variable immunodeficiency (CVID) is characterized by a deficiency or absence of B cells, leading to a reduced ability to produce antibodies and an increased susceptibility to infections.
Incorrect choices:
a. DiGeorge syndrome is a disorder caused by a genetic defect resulting in the underdevelopment of the thymus and parathyroid glands, leading to T cell deficiency.
b. Severe combined immunodeficiency (SCID) is a severe form of immunodeficiency that affects both B and T cells, leading to a complete absence or dysfunction of the immune system.
d. Wiskott-Aldrich syndrome is a rare X-linked genetic disorder characterized by a triad of symptoms, including eczema, low platelet count, and immunodeficiency. It primarily affects T cells and platelets, not B cells.
Correct Answer is C
Explanation
The correct answer is c. Ataxia-telangiectasia. Ataxia-telangiectasia is a rare genetic disorder that affects the cerebellum, causing poor muscle coordination (ataxia) and small, dilated blood vessels (telangiectasias). It also leads to defective T-cell function, making affected individuals more susceptible to infections.
Incorrect choices:
a. X-linked agammaglobulinemia (XLA) is a primary immunodeficiency disorder that primarily affects B-cell function, leading to a lack of mature B cells and low levels of immunoglobulins, but does not involve defective T-cell function.
b. Selective immunoglobulin A (IgA) deficiency is characterized by a deficiency of IgA, but it does not typically lead to defective T-cell function.
d. DiGeorge syndrome is caused by a deletion on chromosome 22 and primarily affects the development of certain organs, including the thymus and parathyroid glands, resulting in T-cell deficiency. While it may lead to some B-cell abnormalities, defective T-cell function is the hallmark of this disorder.
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