Which type of immunodeficiency disorder is characterized by a defect in T cell function and is often associated with developmental delays, chronic infections, and autoimmune manifestations?
X-linked agammaglobulinemia
DiGeorge syndrome
Wiskott-Aldrich syndrome
Severe combined immunodeficiency (SCID)
The Correct Answer is B
Explanation: The correct answer is b. DiGeorge syndrome. This disorder is caused by a deletion in chromosome 22, resulting in the underdevelopment of the thymus and parathyroid glands. It leads to impaired T cell function and is associated with developmental delays, chronic infections, and autoimmune problems.
Incorrect choices:
a. X-linked agammaglobulinemia is a primary immunodeficiency disorder that primarily affects B cell function, leading to a deficiency of immunoglobulins (antibodies).
c. Wiskott-Aldrich syndrome is an X-linked recessive disorder characterized by a triad of symptoms: eczema, thrombocytopenia (low platelet count), and immunodeficiency.
d. Severe combined immunodeficiency (SCID) is a group of rare disorders characterized by a severe deficiency of T cells, B cells, and natural killer (NK) cells.
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Related Questions
Correct Answer is D
Explanation
Explanation: The correct answer is d. Selective IgA deficiency. This disorder is characterized by a lack of immunoglobulin A, which can lead to an increased susceptibility to infections, particularly in the respiratory and gastrointestinal tracts.
Incorrect choices:
a. Selective IgM deficiency is a rare immunodeficiency disorder characterized by a lack of immunoglobulin M (IgM), not IgA.
b. X-linked agammaglobulinemia is a primary immunodeficiency disorder caused by a mutation in the BTK gene, resulting in a deficiency of B cells and immunoglobulins.
c. Common variable immunodeficiency (CVID) is a heterogeneous group of disorders characterized by decreased levels of immunoglobulins, including IgA, IgG, and IgM.
Correct Answer is B
Explanation
Explanation: The correct answer is b. X-linked agammaglobulinemia. X-linked agammaglobulinemia is a primary immunodeficiency disorder caused by a genetic mutation that leads to the absence of mature B cells, resulting in an inability to produce antibodies (immunoglobulins). As a result, individuals with this disorder are highly susceptible to infections, especially bacterial infections.
Incorrect choices:
a. DiGeorge syndrome is a primary immunodeficiency disorder characterized by abnormalities in the development of certain organs, including the thymus, leading to impaired T cell function.
c. Severe combined immunodeficiency (SCID) is a group of rare genetic disorders that affect both T cells and B cells, resulting in a severe impairment of the immune system.
d. Acquired immunodeficiency syndrome (AIDS) is a secondary immunodeficiency disorder caused by the human immunodeficiency virus (HIV) infection, which specifically targets and destroys CD4+ T cells, weakening the immune system's ability to fight infections.
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