Which type of immunodeficiency disorder is characterized by a defect in T cell function and is often associated with developmental delays, chronic infections, and autoimmune manifestations?
X-linked agammaglobulinemia
DiGeorge syndrome
Wiskott-Aldrich syndrome
Severe combined immunodeficiency (SCID)
The Correct Answer is B
Explanation: The correct answer is b. DiGeorge syndrome. This disorder is caused by a deletion in chromosome 22, resulting in the underdevelopment of the thymus and parathyroid glands. It leads to impaired T cell function and is associated with developmental delays, chronic infections, and autoimmune problems.
Incorrect choices:
a. X-linked agammaglobulinemia is a primary immunodeficiency disorder that primarily affects B cell function, leading to a deficiency of immunoglobulins (antibodies).
c. Wiskott-Aldrich syndrome is an X-linked recessive disorder characterized by a triad of symptoms: eczema, thrombocytopenia (low platelet count), and immunodeficiency.
d. Severe combined immunodeficiency (SCID) is a group of rare disorders characterized by a severe deficiency of T cells, B cells, and natural killer (NK) cells.
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Related Questions
Correct Answer is C
Explanation
Explanation: The correct answer is c. Flow cytometry. Flow cytometry is a specialized test used to analyze the different cell types in a blood sample. In the case of SCID, flow cytometry can help identify the absence or severe deficiency of T cells and B cells, which are essential components of the immune system.
Incorrect choices:
a. A tuberculin skin test (TST) is used to detect exposure to tuberculosis (TB) and is not specific to diagnosing SCID.
b. A Western blot test is a type of immunoassay used to detect specific antibodies or antigens in the blood but is not specific to diagnosing SCID.
d. Liver function tests are used to assess the health of the liver and are not specific to diagnosing SCID.
Correct Answer is B
Explanation
Explanation: The correct answer is b. Genetic or inherited defects. Immunodeficiency disorders are primarily caused by genetic mutations or defects that result in a weakened or impaired immune system.
Incorrect choices:
a. While environmental factors can contribute to the development of secondary immunodeficiency disorders, they are not the primary cause of most immunodeficiency disorders.
c. Autoimmune reactions are not the primary cause of immunodeficiency disorders. Autoimmune disorders involve the immune system attacking the body's own tissues, not a deficiency in the immune system.
d. Excessive production of white blood cells is not the primary cause of immunodeficiency disorders. In fact, immunodeficiency disorders are characterized by a deficiency or impairment of white blood cells, which are essential components of the immune system.
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