Which of the following drugs inhibit bacterial beta-lactamase?

A. Sulfonamides:

Sulfonamides are a class of antibiotics that are structurally distinct from cephalosporins like cefazolin. Allergic reactions to sulfonamides do not necessarily indicate a risk of allergy to cefazolin. However, it's still important to assess for any previous allergic reactions to medications, including sulfonamides, as individuals can have multiple medication allergies.

B. Macrolides:

Macrolides are another class of antibiotics that are structurally different from cephalosporins. Allergic reactions to macrolides do not directly indicate an allergy to cefazolin. However, as with sulfonamides, it's crucial to assess for any history of allergic reactions to medications, including macrolides.

C. Yeast:

Yeast is not a class of antibiotics but rather a type of fungus. Allergic reactions to yeast are unrelated to cephalosporin antibiotics like cefazolin. Therefore, a history of allergic reactions to yeast does not suggest an allergy to cefazolin.

D. Penicillin:

This is the correct choice. Penicillins and cephalosporins share a similar beta-lactam ring structure. Individuals who have had allergic reactions to penicillin may have an increased risk of cross-reactivity with cephalosporins, including cefazolin. Therefore, it's crucial to assess for any previous allergic reactions to penicillin before administering cefazolin to avoid potential allergic reactions or adverse effects.

1. Abdominal surgery requires starting antibiotic therapy 4 days before surgery:

This statement is not accurate. While antibiotic prophylaxis is commonly administered before certain types of surgery to prevent surgical site infections, the timing and duration of antibiotic therapy vary depending on factors such as the type of surgery, the patient’s medical history, and institutional guidelines. However, starting antibiotic therapy four days before surgery would not be standard practice for most abdominal surgeries.

B. A reduction of intestinal bacteria lessens the possibility of postoperative infection:

This statement is correct. Neomycin, as well as other antibiotics used in bowel preparation regimens, help reduce the population of intestinal bacteria. By decreasing the bacterial load in the bowel before surgery, the risk of contaminating the surgical site with harmful bacteria during the procedure is reduced, thus lowering the likelihood of postoperative infections.

C. The bacteria found in the bowel cannot be destroyed after surgery:

This statement is incorrect. While it is true that the bowel contains a complex ecosystem of bacteria that play important roles in digestion and other physiological functions, the population of intestinal bacteria can be temporarily reduced through the use of antibiotics, such as neomycin, as part of a bowel preparation regimen before surgery.

D. Anesthesia makes the bowel resistant to an antibiotic after surgery:

This statement is not accurate. Anesthesia does not render the bowel resistant to antibiotics after surgery. However, the administration of antibiotics during surgery and postoperatively may be indicated in certain cases to prevent or treat infections, particularly if the surgical procedure involves contamination of the abdominal cavity or if the patient is at increased risk of infection.