Which class of antibiotic is associated with cartilage toxicity and rupture of the Achilles tendon?

A. Ibuprofen:

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to relieve pain and reduce inflammation. There are no significant interactions reported between erythromycin and ibuprofen.

B. Lasix (Furosemide):

Lasix is a diuretic medication used to treat fluid retention (edema) and high blood pressure. There are no significant interactions reported between erythromycin and furosemide.

C. Lovastatin:

Lovastatin is a statin medication used to lower cholesterol levels. Erythromycin can increase the levels of lovastatin in the blood by inhibiting its metabolism through the CYP3A4 enzyme. This can lead to an increased risk of statin-related side effects, including muscle pain and weakness, and in rare cases, rhabdomyolysis.

D. Lisinopril:

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor used to treat high blood pressure and heart failure. There are no significant interactions reported between erythromycin and lisinopril.

A. Antibiotic dosages below the minimum concentration are prescribed:

This statement is incorrect. When treating MRSA infections, it's essential to prescribe antibiotic dosages that achieve adequate concentrations to effectively combat the resistant bacteria. Suboptimal dosages or inadequate duration of treatment can contribute to treatment failure and the development of antibiotic resistance. Therefore, the nurse should emphasize the importance of prescribing appropriate dosages of antibiotics for MRSA infections.

B. Broad-spectrum antibiotics are used whenever possible:

This statement is not accurate. While broad-spectrum antibiotics may be effective against a wide range of bacteria, they are not always the preferred choice for treating MRSA infections. MRSA is resistant to many antibiotics, including those commonly used as broad-spectrum agents. Therefore, the treatment of MRSA typically involves antibiotics that are specifically effective against this resistant strain, such as vancomycin, daptomycin, linezolid, or other agents based on susceptibility testing. Therefore, the nurse should educate the client that specific antibiotics effective against MRSA are used, rather than relying solely on broad-spectrum antibiotics.

C. Antibiotics are prescribed only when a viral infection is present:

This statement is incorrect. Antibiotics are not effective against viral infections, including those caused by viruses such as influenza or the common cold. MRSA is a bacterial infection, and antibiotics are indicated for its treatment. However, it's essential to use antibiotics judiciously and only when necessary to avoid contributing to antibiotic resistance. The nurse should educate the client that antibiotics are prescribed for bacterial infections like MRSA, but they are not appropriate for viral infections.

D. Infections become resistant to high doses of antibiotics:

This statement is accurate. Overuse or inappropriate use of antibiotics, including high doses, can contribute to the development of antibiotic resistance. Bacteria like MRSA can acquire resistance mechanisms that render antibiotics ineffective, even at high doses. Therefore, it's crucial to use antibiotics judiciously, following appropriate dosing guidelines and duration of treatment, to minimize the risk of antibiotic resistance. The nurse should include this information in the teaching to emphasize the importance of responsible antibiotic use in the management of MRSA infections.