Which of the following clinical manifestations is often observed in individuals with severe combined immunodeficiency (SCID)?

Explanation: The correct answer is c. Autoimmune diseases are a potential complication of primary immunodeficiency disorders. When the immune system is deficient or dysfunctional, it may fail to distinguish between self and non-self antigens, leading to the development of autoimmune diseases.

Incorrect choices:

a. Hypertension is a condition characterized by high blood pressure and is not directly related to primary immunodeficiency disorders.

b. Chronic fatigue syndrome is a complex disorder with unknown causes and is not directly related to primary immunodeficiency disorders.

d. Diabetes mellitus is a metabolic disorder caused by insufficient insulin production or insulin resistance and is not directly related to primary immunodeficiency disorders.

Explanation: The correct answer is c. Failure to thrive. SCID is a severe form of immunodeficiency that affects multiple components of the immune system, leading to recurrent and severe infections and failure to thrive in affected infants.

Incorrect choices:

a. Recurrent ear infections are more commonly seen in other types of immunodeficiency disorders, such as selective IgA deficiency.

b. Chronic fatigue and lethargy may be seen in various medical conditions but are not specific to SCID.

d. Persistent joint pain is not a characteristic symptom of SCID. It may be associated with other autoimmune or inflammatory conditions.