Which of the following clinical manifestations is often observed in individuals with severe combined immunodeficiency (SCID)?
Recurrent ear infections
Chronic fatigue and lethargy
Failure to thrive
Persistent joint pain
The Correct Answer is C
Explanation: The correct answer is c. Failure to thrive. SCID is a severe form of immunodeficiency that affects multiple components of the immune system, leading to recurrent and severe infections and failure to thrive in affected infants.
Incorrect choices:
a. Recurrent ear infections are more commonly seen in other types of immunodeficiency disorders, such as selective IgA deficiency.
b. Chronic fatigue and lethargy may be seen in various medical conditions but are not specific to SCID.
d. Persistent joint pain is not a characteristic symptom of SCID. It may be associated with other autoimmune or inflammatory conditions.
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Correct Answer is B
Explanation
Explanation: The correct answer is b. Persistent fever and night sweats. Fever and night sweats are common clinical manifestations of immunodeficiency disorders. The immune system's inability to fight off infections can lead to recurrent fevers and night sweats as the body tries to combat pathogens.
Incorrect choices:
a. Hyperactivity and restlessness are not typical clinical manifestations of immunodeficiency disorders. These symptoms are more commonly associated with conditions affecting the central nervous system.
c. Weight gain and increased appetite are not typical clinical manifestations of immunodeficiency disorders. They may be seen in conditions like hypothyroidism or hormonal imbalances.
d. Elevated blood pressure is not a common clinical manifestation of immunodeficiency disorders. It may be seen in conditions like hypertension or cardiovascular disorders.
Correct Answer is C
Explanation
Explanation: The correct answer is c. Flow cytometry. Flow cytometry is a specialized test used to analyze the different cell types in a blood sample. In the case of SCID, flow cytometry can help identify the absence or severe deficiency of T cells and B cells, which are essential components of the immune system.
Incorrect choices:
a. A tuberculin skin test (TST) is used to detect exposure to tuberculosis (TB) and is not specific to diagnosing SCID.
b. A Western blot test is a type of immunoassay used to detect specific antibodies or antigens in the blood but is not specific to diagnosing SCID.
d. Liver function tests are used to assess the health of the liver and are not specific to diagnosing SCID.
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