What role do the kidneys have in the pharmacokinetics process?

Excretion

Absorption

Metabolism

Distribution

Answer and Explanation

The Correct Answer is A

A) Excretion:
This is the correct answer. The kidneys play a crucial role in the excretion of drugs and their metabolites from the body. After drugs undergo metabolism in the liver or other tissues, the resulting metabolites are often water-soluble and can be filtered by the kidneys into the urine. This process helps eliminate drugs and their byproducts from the body, preventing their accumulation and potential toxicity.

B) Absorption:
Absorption refers to the movement of drugs from the site of administration into the bloodstream. While the kidneys do not directly facilitate drug absorption, they may indirectly influence drug absorption by regulating blood flow and systemic circulation.

C) Metabolism:
Metabolism, or biotransformation, involves the enzymatic alteration of drugs into metabolites, which are often more water-soluble and easier to excrete. While the liver is the primary site of drug metabolism, the kidneys do not play a direct role in drug metabolism.

D) Distribution:
Distribution refers to the movement of drugs from the bloodstream to various tissues and organs in the body. While the kidneys do not directly influence drug distribution, changes in renal function can affect drug distribution by altering blood flow and plasma protein binding. However, the primary role of the kidneys in pharmacokinetics is excretion, not distribution.

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Correct Answer is C

Explanation

A) Migraines:
Pseudoephedrine is not contraindicated for migraines. In fact, it is sometimes used in combination with other medications to alleviate symptoms of sinus congestion associated with migraines.

B) Diverticulitis:
Pseudoephedrine is not contraindicated for diverticulitis. However, it may cause gastrointestinal side effects such as abdominal discomfort or constipation, which could exacerbate symptoms in individuals with diverticulitis. Therefore, caution should be exercised when using pseudoephedrine in these clients.

C) Hypertension:
This is the correct answer. Pseudoephedrine is a sympathomimetic drug that can cause vasoconstriction and increase blood pressure. Therefore, it is contraindicated in clients with hypertension or cardiovascular disease, as it may exacerbate these conditions and increase the risk of adverse cardiovascular events such as hypertensive crisis or stroke.

D) Eczema:
Pseudoephedrine is not contraindicated for eczema. However, it may cause dryness of the skin and exacerbate existing dermatological conditions. Clients with eczema should use pseudoephedrine cautiously and monitor for any worsening of their skin condition.

A. Weight and caloric intake B. Pulse and blood pressure C. Serum sodium level D. Serum albumin level

Correct Answer is B

Explanation

A) Weight and caloric intake:
While weight and caloric intake are important aspects of overall health assessment, they are not directly related to the administration of beta-adrenergic blocking agents. These medications primarily affect cardiovascular function, so assessing pulse and blood pressure is more pertinent.

B) Pulse and blood pressure:
This is the correct answer. Before administering beta-adrenergic blocking agents, it is essential to assess the client's pulse rate and blood pressure. Beta blockers work by blocking the effects of adrenaline, leading to a decrease in heart rate and blood pressure. Monitoring these vital signs helps determine the appropriateness of administering the medication and allows for adjustments based on the client's current cardiovascular status.

C) Serum sodium level:
Assessing serum sodium level is not typically necessary before administering beta-adrenergic blocking agents. While electrolyte imbalances can occur as a result of certain medications or health conditions, beta blockers do not directly affect serum sodium levels.

D) Serum albumin level:
Assessing serum albumin level is not specifically indicated before administering beta-adrenergic blocking agents. Serum albumin levels may be assessed in clients with certain conditions such as liver or kidney disease, but it is not a routine assessment before administering beta blockers.

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What role do the kidneys have in the pharmacokinetics process?

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Naxlex Comprehensive Predictor Exams

A nurse is reviewing the medical record of a client who reports taking pseudoephedrine for sinus congestion as needed. The nurse should identify that pseudoephedrine is contraindicated for which of the following client conditions?

Correct Answer is C

Explanation

What assessment should the nurse make before administering beta-adrenergic blocking agents?

Correct Answer is B

Explanation

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