A nurse is preparing to administer ticarcillin/clavulanate 3.1 g by intermittent IV bolus over 30 min. Available is ticarcillin/clavulanate 3.1 g in 50 ml 0.9% sodium chloride (NSS). The nurse should set the IV pump to deliver how many mL/hr? (Round the answer to the nearest whole number. Use a leading zero if it applies. Do not use a trailing zero.) _mL/hr

A) By blocking the effects of histamine in the body:
Antihistamines are pharmacological agents that work by antagonizing the effects of histamine, a chemical mediator released by mast cells and basophils in response to allergens or other triggers. Histamine contributes to various allergic symptoms such as itching, sneezing, nasal congestion, and watery eyes. Antihistamines exert their effects by competitively binding to histamine receptors (specifically H1 receptors) on target cells, thereby preventing histamine from binding and exerting its physiological effects. By blocking histamine receptors, antihistamines inhibit the action of histamine, leading to the alleviation of allergy symptoms.

B) By reducing inflammation in the body:
While some medications, such as corticosteroids, exert anti-inflammatory effects by suppressing the immune response and inhibiting the production of inflammatory mediators, antihistamines primarily target histamine receptors and do not directly reduce inflammation. Although histamine release can contribute to inflammation, antihistamines mitigate allergic symptoms primarily by blocking the action of histamine rather than by directly reducing inflammation.

C) By increasing the production of histamine in the body:
This statement is inaccurate. Antihistamines do not increase the production of histamine; instead, they counteract the effects of histamine by blocking its activity at receptor sites. The primary mechanism of action of antihistamines involves blocking histamine receptors to prevent histamine from exerting its physiological effects.

D) By stimulating the immune system:
Antihistamines do not stimulate the immune system. Instead, they act as antagonists to histamine receptors, thereby inhibiting histamine-induced responses. While histamine is involved in immune responses and allergic reactions, antihistamines do not directly modulate immune function or stimulate immune activity. Their primary role is to alleviate allergy symptoms by blocking the effects of histamine."

A) Orthostatic hypotension is indicated by a decrease in diastolic blood pressure of 5 mm Hg:
Orthostatic hypotension is typically defined by a decrease in systolic blood pressure of 20 mm Hg or more or a decrease in diastolic blood pressure of 10 mm Hg or more within three minutes of standing up. Diastolic blood pressure alone is not the primary indicator of orthostatic hypotension.

B) Orthostatic hypotension is indicated by a decrease in systolic blood pressure of 5 mm Hg:
While a decrease in systolic blood pressure is a component of orthostatic hypotension, the criterion for diagnosing orthostatic hypotension is a decrease in systolic blood pressure of 20 mm Hg or more or a decrease in diastolic blood pressure of 10 mm Hg or more within three minutes of standing up.

C) Orthostatic hypotension increases a client's risk of a fall:
This statement is correct. Orthostatic hypotension, characterized by a sudden drop in blood pressure upon standing, can lead to dizziness and lightheadedness, increasing the risk of falls, particularly in older adults.

D) Orthostatic hypotension increases a client's risk of a pulmonary emboli:
Orthostatic hypotension is not directly associated with an increased risk of pulmonary emboli. Pulmonary embolism is a separate condition involving a blockage in the pulmonary artery or its branches, typically caused by a blood clot."