What genetic abnormality would a nurse expect in a client diagnosed with Chronic Myelogenous Leukemia (CML)?

Trisomy 21 (Down syndrome)

Fragile X syndrome

BRCA1 gene mutation

Philadelphia chromosome (BCR-ABL fusion gene)

Answer and Explanation

The Correct Answer is D

A.   Trisomy 21 is a chromosomal disorder resulting in Down syndrome. While individuals with Down syndrome have an increased risk of developing certain leukemias (such as acute lymphoblastic leukemia), it is not directly associated with CML.
B.   Fragile X syndrome is a genetic condition caused by a mutation in the FMR1 gene on the X chromosome, leading to intellectual disability and other developmental issues. It is not associated with CML or any form of leukemia. This option is unrelated to the genetic abnormalities seen in CML.
C.   The BRCA1 gene mutation is associated with an increased risk of breast and ovarian cancers. While mutations in BRCA1 can affect cancer susceptibility, they are not linked to Chronic Myelogenous Leukemia. Thus, this option does not apply to CML.
D.   The Philadelphia chromosome is a specific genetic abnormality found in the majority of patients with CML. It results from a translocation between chromosomes 9 and 22, creating the BCR-ABL fusion gene, which produces a tyrosine kinase that drives the proliferation of leukemic cells.

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Correct Answer is C

Explanation

A. This test is used to measure the level of prolactin, a hormone that stimulates milk production. It is not relevant for cervical cancer screening.
B. This test involves taking a sample of tissue from the lining of the uterus. It is used to diagnose endometrial cancer, not cervical cancer.
C. The Papanicolaou test, commonly known as a Pap smear, is the standard screening test for cervical cancer. It involves collecting cells from the cervix to detect any precancerous changes or cervical cancer itself. This is the correct answer, as it directly relates to cervical cancer screening.
D. This test uses sound waves to create images of the vagina and cervix. It can be used to evaluate the cervix for abnormalities, but it is not as sensitive as a Pap test for detecting cervical cancer.

A. Shortness of breath, especially when lying flat B. Pain/swelling of the lymph nodes C. Low grade fevers of unknown etiology D. Drenching night sweats

Correct Answer is A

Explanation

A. A mass in the mediastinum can compress the trachea or major blood vessels, leading to shortness of breath, particularly when the patient is in a supine position (lying flat). This symptom is indicative of significant obstruction or compression, making it a key sign.
B. While lymphadenopathy (swelling of lymph nodes) is a hallmark of Hodgkin's Lymphoma, it does not specifically indicate the presence of a mediastinal mass. Lymph nodes can swell throughout the body, including cervical, axillary, and inguinal regions, but this symptom is more general and not exclusive to mediastinal involvement.
C. Low-grade fevers can occur in Hodgkin's Lymphoma due to systemic effects of the cancer, such as cytokine release. However, this symptom is nonspecific and does not directly indicate a mediastinal mass. It is more indicative of the body's response to cancer rather than localized effects.
D. Drenching night sweats are another common systemic symptom associated with Hodgkin's Lymphoma. Like low-grade fevers, night sweats are part of the B symptoms that can occur with lymphoma but are not specifically indicative of a mediastinal mass.

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ABG Value	Normal Range
PH	7.35-7.45
PaCO2	35-45 mm Hg
HCO3-	22-26 mEq/L
Base excess	-2 to +2
PaO2	80-95 mm Hg
SaO2	>95%

What genetic abnormality would a nurse expect in a client diagnosed with Chronic Myelogenous Leukemia (CML)?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A nurse is caring for a client who asks to be screened for cervical cancer because a relative has been diagnosed with it. Which of the following tests should the nurse expect the provider to use?

Correct Answer is C

Explanation

A client was recently diagnosed with advanced Hodgkin's Lymphoma. Which sign or symptoms indicates that the lymphoma involves the presence of a mediastinal mass?

Correct Answer is A

Explanation

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