The nurse is caring for a client who has been diagnosed with schizophrenia. The nurse understands that the client's condition is thought to be most likely related to an increased level of activity of what neurotransmitter?

Metformin is an oral medication used to lower blood sugar levels in clients with type 2 diabetes. It works by decreasing the production and absorption of glucose in the liver and intestines, respectively. However, metformin is contraindicated in clients with severe infections, as the drug can increase the risk of developing lactic acidosis, a rare but serious complication characterized by the buildup of lactic acid in the bloodstream.

During a severe infection, the body may experience a state of inflammation and stress, which can cause metabolic changes that increase the risk of developing lactic acidosis. Therefore, metformin should be temporarily discontinued in clients with severe infections and resumed only after the infection has been successfully treated and resolved.

In the meantime, the client's diabetic regimen may need to be adjusted to maintain appropriate blood sugar levels. This may include the use of alternative medications such as insulin, which can be used to control blood sugar levels during times of illness or infection. The healthcare provider will determine the appropriate management plan based on the individual client's needs and medical history.

Schizophrenia is a chronic and severe mental illness that requires lifelong treatment. Antipsychotic medications are the cornerstone of treatment for schizophrenia, and they work by blocking dopamine receptors in the brain. These medications are effective in reducing the positive symptoms of schizophrenia, such as hallucinations and delusions, and can also improve negative symptoms like apathy and lack of motivation.

While chlorpromazine, fluphenazine, and haloperidol are all first-generation or "typical" antipsychotic medications, they are less commonly used today due to their side effect profile, which can include movement disorders such as tardive dyskinesia. Olanzapine, on the other hand, is a second-generation or "atypical" antipsychotic medication that is commonly used today due to its efficacy in treating both positive and negative symptoms of schizophrenia, as well as its more favorable side effect profile compared to first-generation antipsychotics.