The antibody class involved in hypersensitivity reaction Type I is:
IgE
IgA
IgG
IgM
The Correct Answer is A
A. IgE (Immunoglobulin E): This class of antibodies is primarily involved in hypersensitivity reactions Type I, which are immediate allergic reactions. When a person is exposed to an allergen they are sensitive to, IgE antibodies on the surface of mast cells and basophils bind to the allergen. This triggers the release of inflammatory mediators like histamine, leading to allergic symptoms such as itching, hives, and in severe cases, anaphylaxis.
B. IgA (Immunoglobulin A): IgA antibodies are primarily found in mucosal areas such as the respiratory and gastrointestinal tracts. They play a role in immune defense on mucosal surfaces and are important for preventing infections. While IgA is not directly associated with hypersensitivity reactions Type I, deficiencies in IgA can sometimes lead to increased susceptibility to certain infections.
C. IgG (Immunoglobulin G): IgG antibodies are the most common type of antibody in the bloodstream and are involved in various immune responses, including defense against bacterial and viral infections. IgG antibodies are not specific to Type I hypersensitivity reactions; they are part of the immune system's broader defense mechanisms.
D. IgM (Immunoglobulin M): IgM antibodies are the first antibodies to be produced in response to an infection. They are large pentameric molecules and are effective at agglutinating pathogens. IgM antibodies are involved in the primary immune response to infections, but they are not specifically associated with Type I hypersensitivity reactions.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is ["A","B","C","D"]
Explanation
A. Viral Latency: Some viruses, like herpesviruses, can enter a latent phase where they hide in host cells, making it challenging for the immune system to detect and target them.
B. Host Defense Failure: This term encompasses situations where the host's defense mechanisms, including physical barriers and immune responses, are not effective in preventing or controlling infection. For example, pathogens may develop mechanisms to evade detection by the immune system.
C. Immunosuppression: Pathogens can actively suppress the host's immune response. They may produce molecules or proteins that inhibit the immune system's ability to mount an effective defense.
D. Immunodeficiency: Individuals with immunodeficiency disorders have weakened immune systems, which can be congenital (genetic) or acquired. This weakness makes them more susceptible to infections.
Correct Answer is D
Explanation
Allergic reaction: An allergic reaction can manifest in various ways, including rash, itching, and difficulty breathing. However, the specific symptoms described, along with the context of vancomycin administration, point to red man syndrome in this case.
Rhabdomyolysis: Rhabdomyolysis is a condition where damaged muscle tissue breaks down and releases a protein called myoglobin into the bloodstream. This can cause kidney damage, but the symptoms described do not align with rhabdomyolysis.
Stevens-Johnson syndrome: Stevens-Johnson syndrome is a severe skin reaction that can cause skin and mucous membranes to blister, peel, and can be life-threatening. While it can present with rash and other skin symptoms, the symptoms mentioned in the scenario are more characteristic of red man syndrome.
Red man syndrome: As mentioned earlier, red man syndrome is an allergic reaction to vancomycin characterized by flushing, rash, pruritus, and urticaria (hives), along with rapid heart rate and low blood pressure. It is specific to vancomycin and can be prevented or minimized by slowing down the infusion rate and administering antihistamines.
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