The antibody class involved in hypersensitivity reaction Type I is:
IgE
IgA
IgG
IgM
The Correct Answer is A
A. IgE (Immunoglobulin E): This class of antibodies is primarily involved in hypersensitivity reactions Type I, which are immediate allergic reactions. When a person is exposed to an allergen they are sensitive to, IgE antibodies on the surface of mast cells and basophils bind to the allergen. This triggers the release of inflammatory mediators like histamine, leading to allergic symptoms such as itching, hives, and in severe cases, anaphylaxis.
B. IgA (Immunoglobulin A): IgA antibodies are primarily found in mucosal areas such as the respiratory and gastrointestinal tracts. They play a role in immune defense on mucosal surfaces and are important for preventing infections. While IgA is not directly associated with hypersensitivity reactions Type I, deficiencies in IgA can sometimes lead to increased susceptibility to certain infections.
C. IgG (Immunoglobulin G): IgG antibodies are the most common type of antibody in the bloodstream and are involved in various immune responses, including defense against bacterial and viral infections. IgG antibodies are not specific to Type I hypersensitivity reactions; they are part of the immune system's broader defense mechanisms.
D. IgM (Immunoglobulin M): IgM antibodies are the first antibodies to be produced in response to an infection. They are large pentameric molecules and are effective at agglutinating pathogens. IgM antibodies are involved in the primary immune response to infections, but they are not specifically associated with Type I hypersensitivity reactions.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
A. Type IV Hypersensitivity (Delayed Hypersensitivity Reaction): This type of reaction involves a delayed immune response, typically occurring 24 to 72 hours after exposure to an antigen. It's characterized by the activation of T cells and macrophages, leading to inflammation. This type of hypersensitivity is often associated with conditions like contact dermatitis and some autoimmune diseases.
B. Type III Hypersensitivity (Antibody-Mediated Reaction): Type III hypersensitivity reactions occur when immune complexes, which are composed of antigens and antibodies, deposit in various tissues. This leads to inflammation and tissue damage. Systemic lupus erythematosus (SLE) is an example of a disease associated with Type III hypersensitivity.
C. Type II Hypersensitivity: This type of reaction involves antibodies (IgG or IgM) targeting antigens on the surface of cells. This can lead to cell destruction through various mechanisms, such as complement activation or antibody-dependent cell-mediated cytotoxicity (ADCC). Examples include hemolytic transfusion reactions and autoimmune hemolytic anemia.
D. Type I Hypersensitivity (Immediate Hypersensitivity Reaction): Type I hypersensitivity is characterized by an immediate immune response, typically occurring within minutes of exposure to an allergen. It involves the release of histamines and other mediators from mast cells and basophils, leading to symptoms like hives, respiratory distress, and anaphylaxis. Allergies, like hay fever and food allergies, are examples of Type I hypersensitivity reactions.
Correct Answer is D
Explanation
A. Neutrophils: Neutrophils are a type of white blood cell that plays a key role in the immune system's response to infections, particularly bacterial infections. They are not primarily involved in eliminating cancer cells.
B. Eosinophils: Eosinophils are another type of white blood cell. They are important in the immune response to parasites and are also involved in allergic reactions. While they have a role in the immune system, they are not the primary cells involved in eliminating cancer cells.
C. Platelets: Platelets, also known as thrombocytes, are not cells but rather small cell fragments. They are essential for blood clotting and do not directly participate in the immune response against cancer cells.
D. Macrophages: Macrophages are a type of white blood cell that are involved in the immune system's defense against cancer. They are phagocytes, which means they engulf and digest cellular debris, foreign substances, and cancer cells. Macrophages play a crucial role in the body's immune surveillance and response against cancer.
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