A nursing student asks the nursing instructor about the mechanism of the bacteriostatic action of tetracycline. Which explanation is correct?

A. Ototoxicity and Nephrotoxicity:
Ototoxicity: Aminoglycosides can damage the inner ear structures, leading to hearing loss and balance issues.
Nephrotoxicity: These drugs can harm the kidneys, potentially causing acute kidney injury or chronic kidney disease. Monitoring kidney function is crucial to prevent renal damage.

B. Ototoxicity and Cardiotoxicity:
Ototoxicity: As mentioned above, aminoglycosides can damage the inner ear, affecting hearing and balance.
Cardiotoxicity: Aminoglycosides primarily affect the ears and kidneys; they do not directly target the heart. Cardiotoxicity is not a common side effect associated with aminoglycosides.

C. Hepatotoxicity and Nephrotoxicity:
Hepatotoxicity: This term refers to liver damage caused by drugs or toxins. Aminoglycosides are not known to cause liver problems; their primary concern is kidney damage.
Nephrotoxicity: As mentioned earlier, aminoglycosides can harm the kidneys, which is a well-known side effect.

D. Cardiotoxicity and Hepatotoxicity:
Cardiotoxicity: This term refers to the toxic effects on the heart, leading to various heart-related issues. Aminoglycosides do not primarily affect the heart; their main concerns are the ears (ototoxicity) and kidneys (nephrotoxicity).
Hepatotoxicity: Aminoglycosides are not typically associated with liver damage. They are primarily metabolized and excreted by the kidneys, which is why kidney monitoring is crucial during their use.

A. Gut-associated lymphoid tissue (GALT): GALT is a component of the mucosa-associated lymphoid tissue (MALT) and refers to the immune cells found in the gastrointestinal tract. These cells play a significant role in local immune responses in the gut.

B. Bone marrow: The bone marrow is the primary site of blood cell production in the body. It contains stem cells that can differentiate into various blood cells, including B cells. B cells mature in the bone marrow.

C. Thymus: The thymus is an organ located near the heart and is crucial for the development of T cells. T cells mature in the thymus, where they learn to recognize self from non-self antigens.

D. Lymph nodes: Lymph nodes are small, bean-shaped structures that produce and store cells that help fight infection. While they are essential parts of the immune system, B and T cells are not originally derived from lymph nodes.