(Select All That Apply): A nurse is assessing a client for major depressive disorder (MDD). Which of the following signs and symptoms are consistent with the clinical presentation of MDD? Select all that apply.
Increased interest in activities.
Weight gain of 3% in a month.
Excessive guilt and self-blame.
Insomnia.
Elevated mood and increased energy.
Correct Answer : C,D
Choice A rationale:
Increased interest in activities is not consistent with the clinical presentation of MDD. In fact, a hallmark symptom of MDD is anhedonia, which involves a reduced interest or pleasure in most activities.
Choice B rationale:
Weight gain is not typically associated with MDD. In contrast, significant changes in appetite and weight loss are more common symptoms, often accompanied by feelings of worthlessness or guilt related to body image.
Choice C rationale:
Excessive guilt and self-blame are common cognitive and emotional symptoms of MDD. Individuals with MDD tend to have a negative self-perception and may blame themselves for their difficulties.
Choice D rationale:
Insomnia, or difficulty falling asleep or staying asleep, is a common sleep disturbance associated with MDD. Sleep problems can exacerbate the symptoms of depression and impact overall well-being.
Choice E rationale:
Elevated mood and increased energy are actually more indicative of conditions like bipolar disorder or manic episodes, where there are distinct periods of abnormally elevated mood, known as mania or hypomania.
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Naxlex Comprehensive Predictor Exams
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Correct Answer is C
Explanation
Choice A rationale:
Chronic stress is known to activate the Hypothalamic-Pituitary-Adrenal (HPA) axis, which leads to increased cortisol production. While cortisol is important for various physiological functions, chronic elevation of cortisol due to stress can actually have detrimental effects on the brain. Elevated cortisol levels have been associated with impaired neurogenesis (the formation of new neurons) and synaptic plasticity (the ability of synapses to change and adapt), both of which play crucial roles in maintaining cognitive function and mental health.
Choice B rationale:
This statement is not accurate. Chronic stress typically leads to hyperactivity, not hypoactivity, of the HPA axis, resulting in increased levels of cortisol. The increased cortisol levels can negatively impact neurogenesis and synaptic plasticity, which are key factors in depression and cognitive function.
Choice C rationale:
This is the correct statement. Chronic stress triggers hyperactivity of the HPA axis, causing elevated levels of cortisol. While cortisol is meant to help the body cope with stress in the short term, chronic elevation can lead to adverse effects on the brain. High cortisol levels have been linked to impaired neurogenesis and synaptic plasticity, contributing to the development of depression and cognitive deficits.
Choice D rationale:
This statement is not accurate. Chronic stress tends to lead to hyperactivity of the HPA axis and elevated cortisol levels. Reduced cortisol levels, as suggested in this choice, are not commonly associated with chronic stress and its impact on depression.
Correct Answer is C
Explanation
Choice A rationale:
Genetic theory suggests that a person's genetic makeup can predispose them to develop depression, but it does not specifically address the role of neurotransmitters in depression. While genetics can contribute to the risk of major depressive disorder (MDD), this choice doesn't focus on the neurotransmitter imbalances.
Choice B rationale:
Neuroendocrine theory pertains to the role of hormones in depression, particularly abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis. While hormones play a role in mood regulation, this theory does not primarily revolve around neurotransmitter imbalances.
Choice C rationale:
Neurotransmitter theory proposes that an imbalance of neurotransmitters, such as serotonin, norepinephrine, and dopamine, contributes to the development of major depressive disorder. This theory aligns with the idea that these neurotransmitters are responsible for regulating mood, motivation, reward, cognition, and stress response.
Choice D rationale:
Environmental theory suggests that external factors, such as life events and stressors, contribute to the development of depression. While environment can indeed influence depression, it does not specifically address the neurotransmitter imbalances that are central to this question.
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