(Select all that apply) A microbe acquires antibiotic resistance by which means?
Development of medication resistance in the host
Over-riding of the minimum bactericidal concentration
Incorrect dosing, which contributes to ribosome mutations
Transfer of DNA coding to other bacteria
Spontaneous mutation in the microbial genome.
Correct Answer : D,E
A microbe acquires antibiotic resistance by transferring DNA coding to other bacteria or by spontaneous mutation in the microbial genome.
These genetic changes allow the microbe to survive the effects of the antibiotic and pass on the resistance to its offspring.
Choice A is wrong because the host does not develop medication resistance, but the microbe does.
Choice B is wrong because the minimum bactericidal concentration (MBC) is the lowest concentration of an antibiotic needed to kill 99.9% of bacteria, not a mechanism of resistance.
Choice C is wrong because incorrect dosing does not cause ribosome mutations, but may promote the emergence of drug-resistant microbes by exposing them to suboptimal levels of the antibiotic.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
This statement indicates a need for further teaching because linezolid should be taken for the full prescribed course of treatment, even if the symptoms improve or resolve.Stopping the medication too soon can lead to bacterial resistance or recurrence of the infection.
Choice A is wrong because it is a correct statement.Linezolid can cause optic neuropathy or vision changes, so patients should report any changes in their vision to their doctor.
Choice B is wrong because it is a correct statement.
Linezolid can interact with foods that contain tyramine, such as cheese and red wine, and cause a hypertensive crisis.Patients should avoid eating foods that contain tyramine while taking linezolid and for two weeks after stopping the medication.
Choice C is wrong because it is a correct statement.Linezolid can be taken with or without food, but taking it on an empty stomach may help with absorption and effectiveness.
Correct Answer is C
Explanation
Ceftriaxone belongs to the third-generation of cephalosporins.Third-generation cephalosporins have greater activity than the second-generation cephalosporins against certain gram-negative bacteria, such as Streptococcus pneumoniae.They are also more resistant to beta-lactamases, enzymes that can inactivate some cephalosporins.
Choice A is wrong because first-generation cephalosporins have less activity against gram-negative bacteria and are more susceptible to beta-lactamases.
Choice B is wrong because second-generation cephalosporins have less activity against Streptococcus pneumoniae than third-generation cephalosporins, and are also less resistant to beta-lactamases.
Choice D is wrong because fourth-generation cephalosporins have a broader spectrum of activity against gram-negative bacteria, including some that are resistant to third-generation cephalosporins, but they are not more effective against Streptococcus pneumoniae.
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