Order: diphenhydramine 25 mg PO q6h, PRN

Available: diphenhydramine 12.5 mg/5 mL.

How many mL would the nurse give?

A) Nausea
Nausea is not the most common or primary complication associated with thrombolytic drugs. While some patients may experience nausea as a minor side effect, it is not the hallmark complication of thrombolytic therapy. Thrombolytic drugs are used to dissolve blood clots, and their primary concern is related to bleeding due to their potent effect on clotting factors.

B) Hypertension
Hypertension (high blood pressure) is not typically associated with thrombolytic therapy. In fact, thrombolytic drugs are more likely to cause hypotension (low blood pressure) in some cases, especially if bleeding complications lead to significant blood loss.

C) Fever
Fever can occur as a side effect of many medications or conditions, but it is not a common or direct complication of thrombolytic therapy. Fever may occasionally arise as a response to infection, inflammation, or even the breakdown of clots, but it is not a primary concern when using thrombolytic drugs.

D) Bleeding
Bleeding is the most common and serious complication associated with thrombolytic drugs. These medications work by breaking down fibrin, the protein responsible for clot formation, to dissolve blood clots. While this is beneficial in conditions like myocardial infarction, stroke, or pulmonary embolism, it increases the risk of bleeding throughout the body. Bleeding can occur at various sites, including internal bleeding, gastrointestinal bleeding, and bleeding at the injection site.

Given:

Ordered dose of clindamycin palmitate: 225 mg

Concentration of clindamycin palmitate oral suspension: 75 mg/5 mL

Step 1: Set up the proportion:

Desired dose (mg) / Volume to administer (mL) = Concentration (mg/mL)

Step 2: Substitute the values:

225 mg / Volume = 75 mg/5 mL

Step 3: Solve for the unknown volume:

Volume = 225 mg / (75 mg/5 mL)

Volume = 225 mg x (5 mL / 75 mg)

Volume = 15 mL