Which one is not a step of pharmacokinetics?

Distribution:

Metabolism

Absorption

Synthesis

Answer and Explanation

The Correct Answer is D

A) Distribution:. Distribution refers to the process by which a drug is transported throughout the body after it is absorbed into the bloodstream. It involves the movement of the drug to various tissues and organs, where it can exert its effects. Factors such as blood flow, tissue permeability, and protein binding affect distribution.

B) Metabolism:
Metabolism refers to the biochemical process by which the body breaks down drugs into metabolites, usually in the liver. Metabolism can transform drugs into more easily excreted forms and sometimes alters the drug’s activity. It is essential for drug clearance and can affect drug efficacy and toxicity.

C) Absorption:
Absorption is the first step in pharmacokinetics, where the drug enters the bloodstream after being administered. It occurs primarily in the gastrointestinal (GI) tract for oral medications but can also happen in other routes like subcutaneous or intramuscular injections. The rate and extent of absorption are influenced by factors such as drug formulation, route of administration, and presence of food.

D) Synthesis:
Synthesis refers to the process of creating substances, such as drugs or other compounds, typically within the body or in a laboratory setting. While drug synthesis is crucial in drug development, it is not a step involved in the movement or processing of drugs within the body (which is what pharmacokinetics describes). Pharmacokinetics focuses on how the body handles drugs, not how they are created.

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Correct Answer is C

Explanation

Let's calculate the dosage using the provided information.

Information from the label:

Bumetanide concentration: 0.25 mg/mL

Available volume: 10 mL vial

Order: Bumex (bumetanide) 1 mg IV daily

Calculation:

Determine the desired dose: 1 mg

Use the formula:

Desired dose (mg) / Available concentration (mg/mL) = Volume to administer (mL)

Substitute the values:

1 mg / 0.25 mg/mL = Volume to administer (mL)

Calculate:

Volume to administer = 4 mL

Therefore, the correct answer is C. 4 mL

A. 0.5 mL sub-cut B. 1 mL Stat C. 4 mL IV D. 2 mL IM

Correct Answer is D

Explanation

Rationale:

Ordered Dose:

The prescription is for 12 mg of Celestone Soluspan (betamethasone) IM every 24 hours for 2 doses.

Available Dose (from label): The vial contains 6 mg/mL.

Dosage Calculation: Using the formula:

Volumetoadminister(mL) = Availableconcentration(mg/mL) / Ordereddose(mg)

Volumetoadminister = 12mg / 6mg/mL = 2 mL

Administration Route:

The order specifies IM (intramuscular) administration, aligning with the label instructions.

Thus, 2 mL IM is the correct dosage to administer.

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Which one is not a step of pharmacokinetics?

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Naxlex Comprehensive Predictor Exams

Calculate the dosage using the label below. Round to the nearest tenth place. Order: Bumex (bumetanide) 1 mg IV daily Available:

Correct Answer is C

Explanation

Calculate the dosage using the label below. Round to the nearest tenth place. Order: Celestone, Soluspan (betamethasone) 12 mg IM q24 hr. for 2 doses. Available

Correct Answer is D

Explanation

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