An older patient has a prescription for sertraline (Zoloft) 25 mg/day, P O. to be taken for 1 week and then increased to 50 mg/day the second week. The pharmacy gives the patient 50-mg tablets. How many tablets will the patient take per day during the first week?
One and one-half tablets
One-quarter of the tablet
One tablet
Half tablet
The Correct Answer is D
A. One and one-half tablets would exceed the prescribed dose.
B. One-quarter of a tablet would be 12.5 mg, which is less than the prescribed 25 mg.
C. One tablet would provide 50 mg, which is double the prescribed dose for the first week.
D. Half a tablet of a 50 mg tablet would correctly provide the 25 mg dose prescribed for the first week.
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Related Questions
Correct Answer is C
Explanation
A. GABA (gamma-aminobutyric acid) is not typically targeted by antidepressants.
B. While some antidepressants may indirectly affect epinephrine and norepinephrine levels, the primary mechanism of action for most antidepressants is through increasing levels of serotonin and/or norepinephrine.
C. Antidepressants commonly work by increasing the levels of neurotransmitters such as norepinephrine and serotonin in the brain.
D. The reticular formation is not directly involved in the mechanism of action of antidepressants.
Correct Answer is B
Explanation
A. Hearing loss is not a common adverse effect of phenelzine (Nardil).
B. Orthostatic hypotension is a common adverse effect of phenelzine due to its monoamine oxidase inhibitor (MAOI) activity, leading to decreased blood pressure upon standing.
C. Weight loss is not a common adverse effect of phenelzine and may be more indicative of other factors or conditions.
D. Gastrointestinal bleeding is not a common adverse effect of phenelzine.
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