An 18-year-old male is taking Hydroxyurea for treatment of sickle cell anemia. Which options below indicate this medication is working successfully?

The patient experiences a decrease in hemoglobin S.

The patient experiences dehydration due to diuresis

The patient experiences an increase in fetal hemoglobin (Hbg F)

The patient needs fewer blood transfusions.

The patient experiences diuresis

Answer and Explanation

Correct Answer : C,D

A.   The patient experiences a decrease in hemoglobin S. Hydroxyurea does not decrease hemoglobin S levels directly; it works by increasing fetal hemoglobin (Hgb F) levels.
B.   The patient experiences dehydration due to diuresis. This is not an indication that Hydroxyurea is working; it is a potential side effect that should be monitored.
C.   The patient experiences an increase in fetal hemoglobin (Hbg F). Hydroxyurea works by increasing the levels of fetal hemoglobin, which reduces the sickling of red blood cells.
D.   The patient needs fewer blood transfusions. Successful treatment with Hydroxyurea should reduce the frequency of vaso-occlusive crises and the need for blood transfusions.
E.   The patient experiences diuresis. This is not an indicator of the medication's effectiveness; it is a potential side effect.

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Correct Answer is ["A","B","G"]

Explanation

A. Severe pain is a hallmark manifestation of a sickle cell crisis due to vaso-occlusion and tissue ischemia.
B. Fever can occur during a sickle cell crisis, often indicating an underlying infection or inflammatory response.
C. Normal blood counts are not typical during a sickle cell crisis; patients often exhibit anemia, leukocytosis, and thrombocytosis.
D. Clear urine is not a common manifestation of a sickle cell crisis; hematuria or dark-colored urine may occur due to hemolysis or kidney damage.
E. Increased energy levels are not typical during a sickle cell crisis; patients often experience fatigue and malaise.
F. Normal oxygen saturation levels may occur in some patients during a sickle cell crisis, but it is not a consistent finding.
G. Jaundice is common in sickle cell crisis due to hemolysis of red blood cells, leading to an increase in bilirubin levels.

A. The client's tongue is white. B. The client is nauseated. C. The client is jaundiced. D. The client is short of breath. E. The client reports feeling pain.

Correct Answer is ["C","E"]

Explanation

A. The client's tongue being white is not typically associated with sickle cell crisis but may indicate other issues such as oral thrush.
B. Nausea can be a symptom associated with many conditions and is not specific to sickle cell crisis.
C. Jaundice is a common manifestation of sickle cell crisis due to hemolysis of red blood cells, leading to an increase in bilirubin levels.
D. Shortness of breath may occur in sickle cell crisis if there is severe anemia or if the crisis is complicated by acute chest syndrome, but it is not a defining characteristic.
E. Pain is a hallmark symptom of sickle cell crisis, occurring due to vaso-occlusion and tissue ischemia resulting from the sickling of red blood cells.

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An 18-year-old male is taking Hydroxyurea for treatment of sickle cell anemia. Which options below indicate this medication is working successfully?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

Which of the following are common manifestations of a sickle cell crisis? (Select all that apply)

Correct Answer is ["A","B","G"]

Explanation

A 30-year-old who is experiencing sickle cell crisis is admitted to the hospital. During the admission assessment, which findings can the nurse attribute to the client's blood disorder?

Correct Answer is ["C","E"]

Explanation

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