A nurse reads in a drug information guide that PO morphine has a high first-pass effect. Which of the following would the nurse expect?
The drug will be more effective when given in a nonenteral route.
The drug will be most effective when given orally
The drug is excreted by the kidneys at a slower rate than most medications
The kidney will metabolize some of the drug before it reaches the blood stream
The Correct Answer is A
A. The drug will be more effective when given in a nonenteral route:
Morphine has a high first-pass effect when taken orally, meaning that a significant amount of the drug is metabolized in the liver before it reaches systemic circulation. This reduces the amount of active drug available in the bloodstream. To avoid this extensive metabolism, morphine is often administered through nonenteral routes, such as intravenous or subcutaneous, where it bypasses the digestive system and liver first-pass metabolism, resulting in higher systemic bioavailability and effectiveness.
B. The drug will be most effective when given orally:
Due to the high first-pass effect of oral morphine, a significant portion of the drug is metabolized by the liver before it reaches systemic circulation. This means that oral morphine is often less effective compared to other routes of administration, such as intravenous, because the bioavailability of the drug is reduced.
C. The drug is excreted by the kidneys at a slower rate than most medications:
The high first-pass effect primarily affects the drug's absorption and systemic availability rather than its excretion rate. The rate at which a drug is excreted by the kidneys is generally unrelated to its first-pass effect. Morphine’s excretion is influenced by its metabolism and clearance, but not directly by the first-pass effect.
D. The kidney will metabolize some of the drug before it reaches the bloodstream:
The first-pass effect occurs primarily in the liver, not the kidneys. It involves the metabolism of the drug by the liver before it reaches systemic circulation. Therefore, this option incorrectly attributes the first-pass effect to kidney metabolism.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
A) Palliative therapy: Palliative therapy is aimed at providing relief from symptoms and improving the quality of life in patients with serious or terminal illnesses. It does not pertain to the use of antibiotics before culture results are available.
B) Prophylactic therapy: Prophylactic therapy is used to prevent the occurrence of an illness or infection before it happens. For example, antibiotics given before surgery to prevent infections would be considered prophylactic therapy, but this is not the case here.
C) Maintenance therapy: Maintenance therapy is used to sustain a desired level of therapeutic effect after an initial treatment phase. It focuses on keeping a condition under control rather than addressing an acute or uncertain condition.
D) Empiric therapy: Empiric therapy refers to the use of antibiotics or other medications based on clinical judgment and initial symptoms before the results of diagnostic tests, such as wound cultures, are available. This approach is used to start treatment promptly and manage the infection while awaiting precise identification of the pathogen.
Correct Answer is ["B","C","D"]
Explanation
A) Right to education: While educating patients about their medications is important, it is not one of the traditional Five Rights of Medication Administration. Education ensures that patients understand their treatment, potential side effects, and the importance of adherence, but it is not a core component of the Five Rights.
B) Right Dose: Ensuring the correct dose is administered is crucial to avoid underdosing or overdosing, which can lead to ineffective treatment or adverse effects. The right dose is determined based on factors such as the patient’s age, weight, and medical condition.
C) Right Drug: Administering the correct drug is essential to ensure the patient receives the intended therapeutic effect. This involves verifying the medication name, checking for potential drug interactions, and confirming the prescription details.
D) Right Patient: Verifying the patient’s identity before administering medication is critical to prevent medication errors. This typically involves checking the patient’s wristband, asking for their name and date of birth, and cross-referencing with the medication order.
E) Right Assessment: While assessing the patient before medication administration is important, it is not one of the traditional Five Rights. Assessment involves evaluating the patient’s condition, allergies, and potential contraindications to ensure safe medication administration.
F) Right Evaluation: Evaluating the patient’s response to medication is important for ongoing care, but it is not one of the traditional Five Rights. Evaluation helps determine the effectiveness of the medication and identify any adverse reactions or need for dosage adjustments.
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