A nurse is reviewing the medication record for a client diagnosed with chronic kidney disease (CKD). Which of the following medications should the nurse identify as having the potential to cause nephrotoxicity?
Omeprazole
Ondansetron
Vancomycin
Diphenhydramine
The Correct Answer is C
A. Omeprazole: Not directly nephrotoxic, but long-term use has been associated with interstitial nephritis, although rarely.
B. Ondansetron: Generally safe in renal disease and not known to cause nephrotoxicity.
C. Vancomycin: Known nephrotoxic agent, especially with high trough levels or when used with other nephrotoxins; requires dose adjustment in CKD.
D. Diphenhydramine: Not nephrotoxic; primarily affects the CNS and anticholinergic systems.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
Left arm (entire): 9%
Anterior chest: 18%
Total: 9% + 18% = 27%
Correct Answer is D
Explanation
A. Bleeding may occur at injection sites when the intramuscular route is used: While possible, this is not the primary concern.
B. The client can experience nausea and vomiting when given oral medications: This may be true but is secondary to absorption issues.
C. Pain resulting from a burn injury requires relief by the fastest route available: Although IV is fast, the key issue is absorption.
D. Damaged tissue and edema may interfere with drug absorption via other routes: Burned and edematous tissue reduces IM and subcutaneous absorption, making IV the preferred route.
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