A nurse is reviewing laboratory results for a client who has been taking amoxicillin-clavulanate (Augmentin) for a bacterial respiratory tract infection.

Which of the following findings should alert the nurse to a possible adverse effect of this medication? (Select all that apply.).

Choice A rationale:

Hyperglycemia is a key symptom of DKA. It occurs when there is an insufficient amount of insulin in the body to allow glucose to enter cells for use as energy. As a result, the body begins to break down fat for fuel, leading to the production of ketones and causing blood glucose levels to rise1. Normal blood glucose levels are between 4.0 to 6.0 mmol/L when fasting and up to 7.8 mmol/L two hours after eating2.

Choice B rationale:

Ketonuria, or the presence of ketones in the urine, is another symptom of DKA. When the body breaks down fat for energy, ketones are produced. If too many ketones build up in the blood, they can spill over into the urine1.

Choice C rationale:

Metabolic acidosis occurs in DKA due to the accumulation of ketones in the blood. Ketones are acidic, and when they build up in the blood, they cause the blood to become more acidic, leading to metabolic acidosis1.

Choice D rationale:

Hypokalemia is not a symptom of DKA. In fact, patients with DKA often have high potassium levels in their blood at presentation because acidosis causes potassium to move from inside the cells into the bloodstream1. However, during treatment for DKA, when insulin is administered and acidosis is corrected, potassium moves back into the cells and can lead to low potassium levels or hypokalemia1.

Choice E rationale:

Dehydration is a common symptom of DKA. High blood glucose levels lead to increased urination as the body tries to get rid of the excess glucose. This can result in dehydration1.

Choice F rationale:

Kussmaul respirations are a type of hyperventilation that occurs in DKA as the body tries to get rid of excess acids (ketones) through the lungs by breathing rapidly and deeply1.

Choice D rationale:

Taking zolpidem before bedtime is the correct information to include in the education. Zolpidem is a medication used for the short-term treatment of insomnia and should be taken immediately before going to bed to facilitate sleep onset.

Choice A rationale:

Crushing zolpidem to increase absorption is not recommended. The medication should be taken whole and not crushed or chewed.

Choice B rationale:

Storing zolpidem at room temperature is correct. Like many medications, zolpidem should be stored at a controlled room temperature, away from moisture and heat.

Choice C rationale:

Administering zolpidem with a meal is not necessary and may delay the onset of its effects. It is typically taken on an empty stomach for faster absorption.