A nurse is caring for a client who has multiple sclerosis and is experiencing progressive multifocal leukoencephalopathy (PML). Which of the following medications should the nurse recognize is associated with the development of PML?

Choice A Reason:

Chronic cough is correct. Persistent cough is a common symptom of COPD, often occurring due to irritation and inflammation in the airways.

Choice B Reason:

Sputum production is correct. COPD patients frequently experience increased mucus production, leading to coughing up phlegm or sputum, especially in the morning.

Choice C Reason:

Dyspnea is correct. Shortness of breath or dyspnea is a hallmark symptom of COPD, particularly during physical activity or exertion, and it tends to worsen as the disease progresses.

Choice D Reason:

Wheezing occurs due to narrowed airways and increased airway resistance. It is more noticeable during expiration but can also be present during inspiration in severe cases.

Choice E Reason:

Chest tightness is incorrect. While chest tightness can occur in COPD, it is typically more associated with asthma. However, some individuals with COPD may experience chest tightness, especially during exacerbations or when airflow is significantly limited.

Choice A Reason:

Sedatives do not impact the risk of obstructive sleep apnea: This statement is incorrect. Sedatives, particularly those that cause muscle relaxation or depress the central nervous system, can exacerbate obstructive sleep apnea by further relaxing the muscles of the upper airway, leading to increased airway collapse during sleep.

Choice B Reason:

CPAP compliance enhances quality of sleep is correct. Continuous positive airway pressure (CPAP) therapy is a common treatment for obstructive sleep apnea. Compliance with CPAP therapy, meaning consistent and proper use of the CPAP device during sleep, is essential for effectively managing sleep apnea and improving sleep quality.

Choice C Reason:

Alcohol does not affect the risk of obstructive sleep apnea. This statement is incorrect. Alcohol consumption can worsen obstructive sleep apnea by promoting muscle relaxation in the upper airway, leading to increased airway collapse and more frequent episodes of apnea during sleep.

Choice D Reason:

Obesity increases the risk of obstructive sleep apnea. This statement is correct. Obesity is a significant risk factor for obstructive sleep apnea. Excess fat tissue around the neck can increase the likelihood of airway obstruction during sleep, contributing to the development or worsening of sleep apnea.

Choice E Reason:

Positional therapy enhances client comfort is correct. Positional therapy involves strategies to encourage sleeping in positions that minimize the severity of obstructive sleep apnea, particularly for individuals with positional OSA (where apnea events are primarily or significantly worse when sleeping in specific positions, such as supine). This statement is correct.

Choice F Reason:

Smoking increases the risk of obstructive sleep apnea: This statement is correct. Smoking can increase the risk of obstructive sleep apnea due to its effects on upper airway inflammation and respiratory function. Smoking cessation can be beneficial in managing sleep apnea and improving overall health.