A nurse is caring for a client who has multiple sclerosis and is experiencing progressive multifocal leukoencephalopathy (PML). Which of the following medications should the nurse recognize is associated with the development of PML?

Choice A Reason:

Hypoxemia due to dead space is not appropriate. Dead space refers to areas of the lung where ventilation occurs but no perfusion takes place. In ARDS, hypoxemia typically occurs due to ventilation-perfusion (V/Q) mismatch and shunting rather than dead space.

Choice B Reason:

Impaired carbon dioxide elimination due to shunting is not appropriate. Shunting occurs when blood bypasses ventilated alveoli, leading to inadequate gas exchange. In ARDS, shunting contributes to hypoxemia, but it doesn't directly impair carbon dioxide elimination.

Choice C Reason:

Decreased pulmonary arterial pressure due to ventilation-perfusion (V/Q) mismatch is incorrect. V/Q mismatch occurs when ventilation and perfusion are mismatched in different areas of the lung. This leads to areas of low ventilation (dead space) and areas of low perfusion (shunting). V/Q mismatch contributes to hypoxemia in ARDS but does not typically lead to decreased pulmonary arterial pressure.

Choice D Reason:

Decreased pulmonary compliance due to stiffness is correct. This is a characteristic feature of ARDS. The inflammation and damage to the alveoli cause them to become stiff, reducing pulmonary compliance and impairing lung expansion during ventilation.

Choice A Reason:

Encouraging the client to walk regularly is appropriate. Regular exercise, including walking, can help improve mobility, balance, and overall physical function in individuals with Parkinson's disease. It can also help alleviate symptoms such as stiffness and tremors.

Choice B Reason:

Providing the client with fresh fruits and vegetables is appropriate. A healthy diet rich in fresh fruits and vegetables provides essential nutrients, antioxidants, and fiber, which can support overall health and well-being. While diet alone does not directly treat Parkinson's disease, maintaining a nutritious diet is important for overall health.

Choice C Reason:

Restricting fluids to 800 mL/day is inappropriate. Fluid restriction is not typically indicated for individuals with Parkinson's disease unless they have a specific medical condition such as heart failure or kidney disease, which may require fluid restriction as part of their management plan. Restricting fluids excessively can lead to dehydration, which can worsen symptoms such as fatigue, confusion, and constipation, common in Parkinson's disease. Adequate hydration is important for overall health and well-being, including maintaining proper kidney function and preventing urinary tract infections, which individuals with Parkinson's disease may be susceptible to due to urinary retention issues.

Choice D Reason:

Minimizing exposure to outside activities is inappropriate. While it's important for individuals with Parkinson's disease to take precautions to avoid falls and injuries, completely restricting exposure to outside activities is not necessary or advisable. Physical activity, social engagement, and exposure to sunlight are beneficial for both physical and mental health. Encouraging individuals with Parkinson's disease to remain engaged in activities they enjoy, with appropriate safety measures in place, can help maintain their quality of life and overall well-being.

Choice E Reason:

Teaching the client how to use a walker is inappropriate. Assistive devices such as walkers can help individuals with Parkinson's disease maintain mobility and independence, especially if they experience gait disturbances or balance problems. Teaching the client how to use a walker safely and effectively can enhance their quality of life and reduce the risk of falls.