A nurse is caring for a client who has multiple sclerosis and is experiencing progressive multifocal leukoencephalopathy (PML). Which of the following medications should the nurse recognize is associated with the development of PML?

Choice A Reason:

Prodrome is incorrect. The prodrome phase occurs before the onset of the headache and can last for hours to days. During this phase, individuals may experience subtle changes that serve as warning signs of an impending migraine attack. Common prodromal symptoms include fatigue, mood changes, food cravings, increased thirst, and heightened sensitivity to light or sound. Tingling of the face and blind spots in the eyes are not typically associated with the prodrome phase.

Choice B Reason:

Aura is correct. The aura phase of a migraine typically occurs before or during the headache phase and involves neurological symptoms. Aura symptoms can include visual disturbances such as blind spots, zigzag lines, or flashing lights, as well as sensory symptoms like tingling or numbness, often starting in one part of the body and spreading gradually. The tingling of the face and blind spots in the eyes described by the client are consistent with the aura phase of a migraine.

Choice C Reason:

Postdrome is incorrect. The postdrome phase occurs after the headache phase and can last for hours to days. During this phase, individuals may experience lingering symptoms such as fatigue, difficulty concentrating, mood changes, and muscle aches. While some individuals may experience visual disturbances during the postdrome phase, the tingling of the face and blind spots in the eyes described by the client are more characteristic of the aura phase.

Choice D Reason:

Headache is incorrect. The headache phase of a migraine is characterized by moderate to severe throbbing head pain, often accompanied by other symptoms such as nausea, vomiting, and sensitivity to light or sound. While visual disturbances can occur during the headache phase, the tingling of the face and blind spots in the eyes described by the client precede the onset of headache, suggesting the aura phase rather than the headache phase.

Choice A Reason:

Photosensitivity is incorrect. Photosensitivity, or sensitivity to light, is not a common symptom of multiple sclerosis. While individuals with MS may experience visual disturbances, such as blurred vision or optic neuritis, sensitivity to light is not typically reported as a primary symptom.

Choice B Reason:

Memory issues is correct. Memory issues, including problems with short-term memory, concentration, and cognitive processing speed, are common neurological symptoms in individuals with multiple sclerosis. Cognitive impairment can affect various aspects of memory and cognitive function.

Choice C Reason:

Lhermitte's sign is correct. Lhermitte's sign is a classic neurological sign characterized by an electric shock-like sensation that radiates down the spine or into the limbs upon flexing the neck. It is a common symptom in multiple sclerosis, often associated with cervical spinal cord lesions.

Choice D Reason:

Seizures is incorrect. Seizures are not a typical symptom of multiple sclerosis. While individuals with MS may experience various neurological symptoms, seizures are not a common manifestation of the disease.

Choice E Reason:

Central vision loss is correct. Visual disturbances, including central vision loss, blurred vision, double vision, or optic neuritis, are common symptoms of multiple sclerosis. Optic neuritis, inflammation of the optic nerve, is a frequent manifestation of MS that can lead to temporary or permanent central vision loss.