A nurse is administering a daily dose of vancomycin at 10:00 AM. At which time should the nurse obtain the patient's blood sample to determine the trough level?

A. Hypertension: Anaphylaxis often leads to a rapid drop in blood pressure (hypotension) rather than hypertension. Hypotension is a more common symptom because of the severe vasodilation that occurs during anaphylactic reactions.

B. Angioedema: Yes, angioedema is a common clinical manifestation of anaphylaxis. Angioedema involves swelling of the deeper layers of the skin, often around the eyes and lips. It can also affect the throat, which can be life-threatening due to airway obstruction.

C. Petechiae: Petechiae are small red or purple spots that appear on the skin and are caused by bleeding into the skin's tissues. They are not a typical manifestation of anaphylaxis.

D. Bronchospasm: Yes, bronchospasm is a hallmark clinical manifestation of anaphylaxis. It involves the sudden constriction of the airways, leading to difficulty in breathing and wheezing.

A. Dermatitis and headaches: Prednisone use can sometimes cause skin issues, but dermatitis is not a common side effect. Headaches can also occur, but they are not specific to long-term prednisone therapy.

B. Heart failure and headaches: Prednisone does not directly cause heart failure. Headaches can occur but are not specific indicators of prednisone side effects.

C. Hyperglycemia and osteoporosis: Prednisone can lead to elevated blood glucose levels (hyperglycemia) and increased bone loss (osteoporosis) when used long-term. Regular monitoring is essential to manage these potential side effects.

D. Weight loss and hypoglycemia: Prednisone can cause weight gain rather than weight loss. Hypoglycemia (low blood sugar) is not a common side effect of prednisone; it typically causes hyperglycemia (high blood sugar) instead.