A client who received a renal transplant three months ago is readmitted to the acute care unit with signs of graft rejection. While taking the client’s history, the nurse determines that the client has been self-administering St. John's Wort, an herbal preparation on the advice of a friend.
Which information is most significant about this finding?
The client probably used this herb to treat depression.
Wort can decrease plasma concentrations of the cyclosporine.
Ingestion of wort can reduce the client’s intake of sodium.
Adding the herb can decrease the need for corticosteroids.
Adding the herb can decrease the need for corticosteroids.
The Correct Answer is B
Cyclosporine is an immunosuppressive medication commonly used to prevent graft rejection after organ transplantation. St. John's Wort is known to induce cytochrome P450 enzymes, which can increase the metabolism and decrease the effectiveness of many medications, including cyclosporine. This interaction can lead to decreased plasma concentrations of cyclosporine, which can increase the risk of graft rejection. Therefore, it is important to advise the client to discontinue the use of St. John's Wort and inform their healthcare provider about any herbal or supplement use to prevent potential interactions with prescribed medications. Options a, c, and d are not directly related to the client's current condition and are not as significant as option b.

Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is ["A","D"]
Explanation
The correct answer is:
a. Report any tendon pain or swelling to the healthcare provider immediately.
d. Limit exposure to sunlight and avoid tanning beds.
Choice A: Report any tendon pain or swelling to the healthcare provider immediately.
Ciprofloxacin, like other fluoroquinolones, can cause tendinitis and tendon rupture. This risk is higher in older adults, those on corticosteroid therapy, and those with kidney, heart, or lung transplants. Reporting any tendon pain or swelling immediately is crucial to prevent severe complications.
Choice B: Use NSAIDS to relieve mid joint aches and pains caused by the medication.
This is not recommended. Using NSAIDs with ciprofloxacin can increase the risk of central nervous system effects, including seizures. Therefore, it is not advised to use NSAIDs to relieve joint aches and pains caused by ciprofloxacin.
Choice C: Crush and mix the tablets with pudding if you have trouble swallowing the tablets.
Ciprofloxacin tablets should not be crushed. Crushing the tablets can affect the drug’s effectiveness and increase the risk of side effects. If swallowing is an issue, the healthcare provider should be consulted for alternative forms of the medication.
Choice D: Limit exposure to sunlight and avoid tanning beds.
Ciprofloxacin can increase the skin’s sensitivity to sunlight, leading to severe sunburns. Patients are advised to limit their exposure to sunlight and avoid tanning beds while taking this medication.
Correct Answer is A
Explanation
Insulin glargine is a long-acting insulin that is given once daily at the same time every day via subcutaneous injection. Therefore, it is essential to teach the client self-injection skills for daily subcutaneous administration to ensure proper administration of insulin.
Option b is incorrect because insulin glargine is typically given at the same dose every day, not based on before meal blood sugar readings.
Option c is incorrect because insulin glargine is not used for the treatment of severe hypoglycemia, and it should not be administered by someone who is not trained to do so.
Option d is incorrect because ketoacidosis is a serious complication of diabetes mellitus that requires urgent medical atention, and increasing medication dosage is not appropriate for this condition.

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