Percutaneous Umbilical Blood Sampling (PUBS)

• PUBS is a prenatal diagnostic test that involves obtaining a small sample of fetal blood from the umbilical cord for chromosomal analysis
• PUBS can detect chromosomal abnormalities such as Down syndrome, trisomy 13, trisomy 18, .
• PUBS can also detect some genetic disorders such as cystic fibrosis, Tay-Sachs disease, sickle cell disease, .
• PUBS can also detect some blood disorders such as hemolytic anemia, thrombocytopenia, .
• PUBS can also provide fetal blood transfusion or medication delivery if needed
• PUBS is usually performed after 18 weeks of gestation
• PUBS involves inserting a thin needle through the abdomen and uterus and into the umbilical cord under ultrasound guidance
• PUBS has a risk of miscarriage of about 1% to 2%
• PUBS has a risk of infection, bleeding, cramping, leaking of amniotic fluid, Rh sensitization, injury to the fetus or placenta, .
• PUBS results are usually available within 24 to 48 hours