Which response best connects the pathology of myasthenia gravis with its signs and symptoms (S&S)?
A sudden, explosive, disorderly charge of neurons causes a transient aberration in brain function
Loss of the myelin sheath surrounding peripheral nerves causes asymmetric weakness
Destruction of acetylcholine receptors causes muscle weakness with prolonged activity.
A bacterial inflammatory illness that causes headache and photophobia.
The Correct Answer is C
A. A sudden, explosive, disorderly charge of neurons causes a transient aberration in brain function: This describes the pathophysiology of seizures, not myasthenia gravis.
B. Loss of the myelin sheath surrounding peripheral nerves causes asymmetric weakness: This describes multiple sclerosis, not myasthenia gravis.
C. Destruction of acetylcholine receptors causes muscle weakness with prolonged activity: Myasthenia gravis is an autoimmune disease where antibodies attack acetylcholine receptors at the neuromuscular junction, leading to muscle weakness, especially after repeated use.
D. A bacterial inflammatory illness that causes headache and photophobia: This describes meningitis, not myasthenia gravis.
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Correct Answer is D
Explanation
A. Vertigo and bilateral loss of the pupillary light reflex: Vertigo can occur with cerebellar involvement, but loss of the pupillary light reflex is more associated with brainstem damage.
B. Nuchal rigidity and positive Kernig's sign: These are signs of meningitis, not a cerebellar stroke.
C. Report of falling down, nausea, and vomiting: These symptoms can occur with cerebellar strokes, but they are nonspecific and can be seen in other conditions as well.
D. Difficulty speaking and loss of coordination: The cerebellum is responsible for coordination, and a cerebellar stroke can lead to ataxia (loss of coordination) and dysarthria (difficulty speaking).
Correct Answer is C
Explanation
A. A sudden, explosive, disorderly charge of neurons causes a transient aberration in brain function: This describes the pathophysiology of seizures, not myasthenia gravis.
B. Loss of the myelin sheath surrounding peripheral nerves causes asymmetric weakness: This describes multiple sclerosis, not myasthenia gravis.
C. Destruction of acetylcholine receptors causes muscle weakness with prolonged activity: Myasthenia gravis is an autoimmune disease where antibodies attack acetylcholine receptors at the neuromuscular junction, leading to muscle weakness, especially after repeated use.
D. A bacterial inflammatory illness that causes headache and photophobia: This describes meningitis, not myasthenia gravis.
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