Which potential reaction causes the most concern when administering medication to a patient with decreased albumin and globulin levels?.
There may be an increase in the amount of lipid-soluble drugs in the system.
There may be increased free protein-bound drugs available, increasing the potential for adverse drug reactions.
Water-soluble drugs will be absorbed more completely.
Metabolism of protein-bound drugs will be decreased, increasing the potential for adverse reactions.
The Correct Answer is B
Choice A rationale:
An increase in the amount of lipid-soluble drugs in the system can occur with decreased albumin and globulin levels, but it does not cause the most concern.
Choice B rationale:
Increased free protein-bound drugs available can lead to an increased potential for adverse drug reactions. This is because these drugs are usually more active and can lead to toxicity.
Choice C rationale:
Water-soluble drugs being absorbed more completely is not typically a concern with decreased albumin and globulin levels.
Choice D rationale:
While metabolism of protein-bound drugs may be decreased, leading to an increased potential for adverse reactions, this is not the primary concern with decreased albumin and globulin levels.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
Choice A rationale:
An allergic reaction refers to an immune response to a foreign substance. It does not describe the interaction between an antacid and ketoconazole.
Choice B rationale:
Displacement refers to one drug replacing another at the drug-binding site on proteins, altering the distribution of the displaced drug. It does not describe the interaction between an antacid and ketoconazole.
Choice C rationale:
Accumulation refers to the buildup of a drug in the body due to inadequate metabolism or excretion. It does not describe the interaction between an antacid and ketoconazole.
Choice D rationale:
A drug interaction occurs when the effect of one drug is altered by the administration of another drug. Antacids can slow the dissolution and absorption of ketoconazole, which is a type of drug interaction.
Correct Answer is C
Explanation
Choice A rationale:
The frequency of drug administration doesn’t necessarily determine the therapeutic range.
Choice B rationale:
Protein binding is not directly related to the frequency of drug administration.
Choice C rationale:
Drug A has a longer half-life than drug B. This is because drugs with longer half-lives need to be administered less frequently.
Choice D rationale:
The toxicity of a drug is not determined by the frequency of its administration.
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