Which potential reaction causes the most concern when administering medication to a patient with decreased albumin and globulin levels?.
There may be an increase in the amount of lipid-soluble drugs in the system.
There may be increased free protein-bound drugs available, increasing the potential for adverse drug reactions.
Water-soluble drugs will be absorbed more completely.
Metabolism of protein-bound drugs will be decreased, increasing the potential for adverse reactions.
The Correct Answer is B
Choice A rationale:
An increase in the amount of lipid-soluble drugs in the system can occur with decreased albumin and globulin levels, but it does not cause the most concern.
Choice B rationale:
Increased free protein-bound drugs available can lead to an increased potential for adverse drug reactions. This is because these drugs are usually more active and can lead to toxicity.
Choice C rationale:
Water-soluble drugs being absorbed more completely is not typically a concern with decreased albumin and globulin levels.
Choice D rationale:
While metabolism of protein-bound drugs may be decreased, leading to an increased potential for adverse reactions, this is not the primary concern with decreased albumin and globulin levels.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
Choice A rationale:
Absorption is not primarily affected by the functioning of hepatic enzymes.
Choice B rationale:
Distribution is not the main concern when dealing with abnormal functioning of hepatic enzymes.
Choice C rationale:
Excretion is mainly a function of the kidneys, not the liver.
Choice D rationale:
Metabolism is the aspect of pharmacokinetics most affected by the functioning of hepatic enzymes. The liver plays a crucial role in the metabolism of drugs.
Correct Answer is D
Explanation
Choice A rationale:
Protein binding does not inactivate the drug. Instead, it can affect the drug’s distribution and bioavailability.
Choice B rationale:
Protein binding does not directly increase the risk of an allergic reaction. Allergic reactions are typically immune responses to a drug, not a result of protein binding.
Choice C rationale:
An idiosyncratic reaction is an unusual or unexpected reaction to a drug, which is not related to protein binding.
Choice D rationale:
Protein binding can lead to the accumulation of the drug. Drugs often cannot cross membranes mainly due to the high molecular mass of the drug-protein complex, resulting in the accumulation of the active compounds.
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