Which organ is primarily responsible for excretion of a medication?

Kidneys

Pancreas

Gallbladder

Liver

Answer and Explanation

The Correct Answer is A

Choice A reason: This is correct. The kidneys are the main organs for excreting water-soluble substances, including most drugs and their metabolites. The kidneys filter the blood and remove waste products and excess fluid as urine. Drugs can be excreted by glomerular filtration, tubular secretion, or tubular reabsorption.

Choice B reason: This is incorrect. The pancreas is not involved in excretion of drugs. The pancreas is an organ that produces digestive enzymes and hormones, such as insulin and glucagon.

Choice C reason: This is incorrect. The gallbladder is not involved in excretion of drugs. The gallbladder is an organ that stores and concentrates bile, a fluid that helps digest fats.

Choice D reason: This is incorrect. The liver is not primarily responsible for excretion of drugs, although it plays an important role in drug metabolism. The liver is an organ that performs many functions, such as detoxifying substances, synthesizing proteins, and producing bile. The liver can transform drugs into more polar and water-soluble compounds, which can then be excreted by the kidneys or the biliary system.

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Correct Answer is D

Explanation

Choice A reason: Increased respiratory rate is not a sign of adverse reaction to metoprolol, but rather a normal response to hypoxia or distress. Metoprolol is a betablocker that can lower the heart rate and blood pressure, but it does not affect the respiratory rate directly.

Choice B reason: Bronchodilation is not a sign of adverse reaction to metoprolol, but rather a desired effect of asthma medications such as betaagonists or anticholinergics. Metoprolol is a betablocker that can block the beta receptors in the lungs, which can cause bronchoconstriction or narrowing of the airways. This is why metoprolol is contraindicated or used with caution in clients with asthma.

Choice C reason: Decreased sputum production is not a sign of adverse reaction to metoprolol, but rather a result of effective asthma management. Metoprolol is a betablocker that does not have any direct effect on the mucus secretion or inflammation in the lungs.

Choice D reason: Wheezing is a sign of adverse reaction to metoprolol, as it indicates bronchoconstriction or narrowing of the airways. Metoprolol is a betablocker that can block the beta receptors in the lungs, which can reduce the bronchodilation effect of beta agonists or other asthma medications. This can worsen the asthma symptoms and cause wheezing, coughing, dyspnea, or chest tightness. The nurse should monitor the client for these signs and report them to the prescriber immediately.

A. Relief of heartburn B. Cessation of diarrhea C. Passage of flatus D. Absence of constipation

Correct Answer is A

Explanation

Choice A reason: Relief of heartburn is the correct outcome that indicates that famotidine is therapeutic. Famotidine is a medication that belongs to the class of H2 receptor antagonists, which work by blocking the action of histamine on the H2 receptors of the stomach cells, thereby reducing the production of gastric acid. Famotidine is used to treat and prevent conditions such as gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger Ellison syndrome, which are characterized by excessive acid secretion and irritation of the esophagus and stomach. Famotidine can relieve the symptoms of heartburn, which is a burning sensation in the chest or throat caused by the reflux of stomach acid into the esophagus.

Choice B reason: Cessation of diarrhea is not an outcome that indicates that famotidine is therapeutic. Famotidine is a medication that belongs to the class of H2 receptor antagonists, which work by blocking the action of histamine on the H2 receptors of the stomach cells, thereby reducing the production of gastric acid. Famotidine does not affect the motility or secretion of the intestines, and it is not used to treat diarrhea, which is a condition of frequent and loose bowel movements. Diarrhea can have various causes, such as infections, medications, food intolerance, or inflammatory bowel disease, and it requires different treatments depending on the underlying cause. Famotidine is not effective for treating diarrhea, and it may even worsen it by reducing the acidity of the stomach and increasing the risk of bacterial overgrowth.

Choice C reason: Passage of flatus is not an outcome that indicates that famotidine is therapeutic. Famotidine is a medication that belongs to the class of H2 receptor antagonists, which work by blocking the action of histamine on the H2 receptors of the stomach cells, thereby reducing the production of gastric acid. Famotidine does not affect the digestion or fermentation of food in the gastrointestinal tract, and it is not used to treat flatulence, which is the accumulation and expulsion of gas from the stomach or intestines. Flatulence can have various causes, such as swallowing air, eating certain foods, or having a bacterial imbalance in the gut, and it requires different treatments depending on the underlying cause. Famotidine is not effective for treating flatulence, and it may even increase it by reducing the acidity of the stomach and altering the gut flora.

Choice D reason: Absence of constipation is not an outcome that indicates that famotidine is therapeutic. Famotidine is a medication that belongs to the class of H2 receptor antagonists, which work by blocking the action of histamine on the H2 receptors of the stomach cells, thereby reducing the production of gastric acid. Famotidine does not affect the motility or secretion of the intestines, and it is not used to treat constipation, which is a condition of infrequent or difficult bowel movements. Constipation can have various causes, such as dehydration, lack of fiber, medications, or bowel obstruction, and it requires different treatments depending on the underlying cause. Famotidine is not effective for treating constipation, and it may even cause it by reducing the acidity of the stomach and slowing down the digestion.

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Which organ is primarily responsible for excretion of a medication?

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Naxlex Comprehensive Predictor Exams

A nurse is caring for a client with asthma who is prescribed metoprolol. The nurse should monitor the client for which of the following?

Correct Answer is D

Explanation

A nurse is taking a health history of a client who reports occasionally taking several over-the-counter medications, including an H2 receptor antagonist (famotidine). Which of the following outcomes indicates that famotidine is therapeutic?

Correct Answer is A

Explanation

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