What does the term 'first pass effect' refer to?
The initial phase of drug distribution
The rapid absorption of a drug in the intestine
The initial rapid excretion of a drug through the urinary system
The metabolism of a drug before it reaches the systemic circulation
The Correct Answer is D
Choice A reason: The initial phase of drug distribution is not the correct definition of the term 'first pass effect'. Drug distribution is the process by which a drug moves from the bloodstream to the tissues and organs of the body. The initial phase of drug distribution is influenced by factors such as blood flow, tissue permeability, plasma protein binding, and tissue binding. The first pass effect is not related to drug distribution, but to drug metabolism, which is the chemical transformation of a drug in the body.
Choice B reason: The rapid absorption of a drug in the intestine is not the correct definition of the term 'first pass effect'. Drug absorption is the process by which a drug enters the bloodstream from the site of administration. The rapid absorption of a drug in the intestine depends on factors such as the drug formulation, the pH of the gastrointestinal tract, the presence of food or other drugs, and the surface area and motility of the intestine. The first pass effect is not related to drug absorption, but to drug metabolism, which is the chemical transformation of a drug in the body.
Choice C reason: The initial rapid excretion of a drug through the urinary system is not the correct definition of the term 'first pass effect'. Drug excretion is the process by which a drug or its metabolites are eliminated from the body. The initial rapid excretion of a drug through the urinary system is influenced by factors such as the renal blood flow, the glomerular filtration rate, the tubular secretion and reabsorption, and the urine pH. The first pass effect is not related to drug excretion, but to drug metabolism, which is the chemical transformation of a drug in the body.
Choice D reason: The metabolism of a drug before it reaches the systemic circulation is the correct definition of the term 'first pass effect'. Drug metabolism is the process by which a drug is chemically transformed in the body, usually by enzymes in the liver or other tissues. The first pass effect is a phenomenon of drug metabolism that occurs when a drug is administered orally and passes through the gastrointestinal tract and the liver before reaching the systemic circulation. The first pass effect can reduce the bioavailability and the effectiveness of the drug, as some or most of the drug may be metabolized and inactivated before reaching the site of action.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Choice A reason: This is correct. The kidneys are the main organs for excreting water-soluble substances, including most drugs and their metabolites. The kidneys filter the blood and remove waste products and excess fluid as urine. Drugs can be excreted by glomerular filtration, tubular secretion, or tubular reabsorption.
Choice B reason: This is incorrect. The pancreas is not involved in excretion of drugs. The pancreas is an organ that produces digestive enzymes and hormones, such as insulin and glucagon.
Choice C reason: This is incorrect. The gallbladder is not involved in excretion of drugs. The gallbladder is an organ that stores and concentrates bile, a fluid that helps digest fats.
Choice D reason: This is incorrect. The liver is not primarily responsible for excretion of drugs, although it plays an important role in drug metabolism. The liver is an organ that performs many functions, such as detoxifying substances, synthesizing proteins, and producing bile. The liver can transform drugs into more polar and water-soluble compounds, which can then be excreted by the kidneys or the biliary system.
Correct Answer is D
Explanation
Choice A reason: This is incorrect. Taking antacids does not protect the stomach from the irritation caused by spicy foods. Antacids only reduce the acidity of the stomach contents, but they do not heal the ulcer or prevent further damage.
Choice B reason: This is incorrect. Taking antacids does not affect the digestion of carbohydrates or any other nutrients. Antacids only act on stomach acid, not on the enzymes that break down food.
Choice C reason: This is incorrect. Taking antacids does not stop the stomach from producing acid. Antacids only react with the acid that is already present in the stomach, but they do not inhibit the secretion of acid by the stomach cells.
Choice D reason: This is correct. Taking antacids will help neutralize the acid that is already in the stomach, which can relieve the pain and discomfort caused by the ulcer. Antacids can also form a protective coating over the ulcer, which can help it heal faster.
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