Which organ is primarily responsible for drug metabolism?

Liver

Lungs

Heart

Kidney

Answer and Explanation

The Correct Answer is A

Choice A reason: This is correct. The liver is the main organ responsible for drug metabolism. The enzymes that the body uses to metabolize drugs are present throughout the body but are most abundant in the liver. The liver can transform drugs into more polar and water-soluble compounds, which can then be excreted by the kidneys or the biliary system.

Choice B reason: This is incorrect. The lungs are not primarily responsible for drug metabolism, although they can play a minor role in some cases. The lungs can metabolize some drugs that are inhaled, such as anesthetics, or drugs that circulate through the pulmonary blood vessels, such as propranolol. However, the lungs have a lower capacity and a lower variety of enzymes than the liver.

Choice C reason: This is incorrect. The heart is not responsible for drug metabolism, although it can be affected by it. The heart is the organ that pumps blood throughout the body, delivering oxygen and nutrients to the tissues and organs. The heart can be influenced by the pharmacokinetics and pharmacodynamics of drugs, which are the processes of drug absorption, distribution, metabolism, and excretion, and the effects of drugs on the body, respectively.

Choice D reason: This is incorrect. The kidney is not primarily responsible for drug metabolism, although it is important for drug excretion. The kidney is the organ that filters the blood and removes waste products and excess fluid as urine. The kidney can excrete drugs that are water-soluble or that are not reabsorbed by the tubules. The kidney can also metabolize some drugs, such as aspirin, but to a lesser extent than the liver.

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Correct Answer is A

Explanation

Choice A reason: Vasoconstriction is the desired therapeutic effect of phenylephrine in this context. Phenylephrine is a medication that stimulates the alpha1 receptors on the blood vessels, causing them to constrict or narrow. This increases the resistance to blood flow and raises the blood pressure. Phenylephrine is used as a vasopressor to treat hypotension, which is a condition of low blood pressure that can cause dizziness, fainting, or organ damage. The nurse should monitor the blood pressure and the peripheral pulses of the patient after administering phenylephrine.

Choice B reason: Bronchodilation is not the desired therapeutic effect of phenylephrine in this context. Phenylephrine is a medication that stimulates the alpha1 receptors on the blood vessels, causing them to constrict or narrow. It has no effect on the beta2 receptors on the bronchial smooth muscle, which are responsible for bronchodilation or widening of the airways. Phenylephrine is not used to treat respiratory conditions, such as asthma or chronic obstructive pulmonary disease, that cause bronchoconstriction or narrowing of the airways. The nurse should assess the respiratory rate and the breath sounds of the patient after administering phenylephrine.

Choice C reason: Diuresis is not the desired therapeutic effect of phenylephrine in this context. Phenylephrine is a medication that stimulates the alpha1 receptors on the blood vessels, causing them to constrict or narrow. It has no effect on the kidney function or the urine output. Phenylephrine is not used to treat fluid retention or edema, which are conditions of excess fluid in the body that can cause swelling, weight gain, or heart failure. The nurse should measure the urine output and the specific gravity of the patient after administering phenylephrine.

Choice D reason: Decreased heart rate is not the desired therapeutic effect of phenylephrine in this context. Phenylephrine is a medication that stimulates the alpha1 receptors on the blood vessels, causing them to constrict or narrow. It has little or no effect on the beta1 receptors on the heart, which are responsible for increasing the heart rate and the contractility. Phenylephrine may actually cause a reflex bradycardia, which is a slow heart rate that occurs when the baroreceptors in the blood vessels sense an increase in blood pressure and send signals to the brain to lower the heart rate. Phenylephrine is not used to treat tachycardia, which is a fast heart rate that can cause palpitations, chest pain, or arrhythmias. The nurse should monitor the electrocardiogram and the heart rate of the patient after administering phenylephrine.

A. Aspirin, acetaminophen, and caffeine B. Ibuprofen, naproxen, and caffeine C. Aspirin, loratadine, and caffeine D. Acetaminophen, naproxen, and loratadine

Correct Answer is A

Explanation

Choice A reason: This is correct. Excedrin contains a combination of aspirin, acetaminophen, and caffeine. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain, inflammation, and swelling. Acetaminophen is a pain reliever and a fever reducer. Caffeine is a central nervous system stimulant that enhances the pain-relieving function of aspirin and acetaminophen.

Choice B reason: This is incorrect. Ibuprofen and naproxen are both NSAIDs, but they are not the same as aspirin. They have different chemical structures and may have different effects and side effects. Caffeine is not an ingredient in ibuprofen or naproxen products.

Choice C reason: This is incorrect. Loratadine is an antihistamine that is used to treat allergies, not headaches. It does not have any pain-relieving or anti-inflammatory properties. Caffeine is not an ingredient in loratadine products.

Choice D reason: This is incorrect. Naproxen is an NSAID, but it is not the same as aspirin. It has a different chemical structure and may have different effects and side effects. Loratadine is an antihistamine that is used to treat allergies, not headaches. It does not have any pain-relieving or anti-inflammatory properties. Caffeine is not an ingredient in acetaminophen, naproxen, or loratadine products.

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Which organ is primarily responsible for drug metabolism?

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Naxlex Comprehensive Predictor Exams

A nurse is preparing to administer phenylephrine as a vasopressor to treat a patient for hypotension. The desired therapeutic effect of phenylephrine in this context is:

Correct Answer is A

Explanation

A patient with frequent tension headaches asks the nurse about over-the-counter remedies. The nurse knows that Excedrin combines which of the following active ingredients to address pain, inflammation, and increased vascular tone associated with headaches?

Correct Answer is A

Explanation

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